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대장의 샘종 및 샘암종에서 Osteopontin, ZO-1 및 E-cadherin의 발현

Expression of Osteopontin, ZO-1 and E-cadherin in Adenoma and Adenocarcinoma of the Colon

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Abstract

Background : The expressions of osteopontin (OPN), zonula occludens-1 (ZO-1) and E-cadherin, known as cell adhesion-associated substances, were examined in adenoma and adenocarcinoma of the colon. The relationship of their expressions with clinicopathologic factors was examined to investigate the roles of these proteins in the development, invasion or metastasis of colon adenocarcinoma. Methods : The expressions of OPN, ZO-1, and E-cadherin were examined in 54 cases of adenoma and 67 cases of adenocarcinoma of the colon by immunohistochemical staining. Results : The expression of OPN in colon adenocarcinoma correlated with staging (p=0.012) and distant metastasis (p=0.021). The expression of ZO-1 was closely related with tumor cell differentiation (p<0.001), and the reduced expression of E-cadherin was associated with tumor cell differentiation (p=0.05) and lymph node metastasis (p<0.001). Co-expression of ZO-1 and E-cadherin was significantly associated with tumor cell differentiation, and the expressions of ZO-1 and E-cadherin were reduced or lost in all cases (5 cases) of poorly differentiated adenocarcinoma. Conclusions : Our data suggest that OPN is involved in the process of invasion and metastasis of colon adenocarcinoma, and ZO-1- and E-cadherin- mediated cell adhesion may play an important role in the differentiation of colon adenocarcinoma.

참고문헌 (28)

  1. "Death by cause"
  2. "Adhesion molecules:novel molecular toolsin tumor pathology", 25, pp.849~56 (1994)
  3. "Osteopontin expressionand distribution in human carcinomas", 145, pp.610~23 (1994)
  4. "The functional and clinical roles of osteopontin in cancer and metastasis", 1, pp.621~32 (2001)
  5. "Osteopontin:a versatile regulator of inflammationand biomineralization", 19, pp.615~22 (2000)
  6. "Vascular endothelialgrowth factor and osteopontin in tumor biology", 11, pp.135~46
  7. "Induction ofexpression of osteopontin", pp.43~7
  8. "Secreted phosphoproteinmRNA is induced during multi-stage carcinogenesis in mouseskin and correlates with the metastatic potential of murine fibroblasts", 46, pp.133~7 (1990)
  9. "Correlation of osteopontinprotein expression and pathological stage across a wide variety oftumor histologies", 10, pp.184~90 (2004), Clin Cancer Res
  10. "Osteopontin and p53 expressionare associated with tumor progression in a case of synchronous,bilateral,invasive mammary carcinomas", 121, pp.578~84 (1997)
  11. "Osteopontin identified as lead markerof colon cancer progression,using pooled sample expression profiling", 94, pp.513~21 (2002)
  12. "Quantification of osteopontinin human plasma with an ELISA:basal levels in pre- and postmenopausalwomen", 29, pp.231~9 (1996)
  13. "Elevated plasma osteopontinin metastatic breast cancer associated with increased tumor burdenand decreased survival", 3, pp.605~11 (1997), Clin Cancer Res
  14. "Osteopontin as a potential diagnosticbiomarker for ovarian cancer", 287, pp.1671~9 (2002)
  15. "Expression of occludin,tightjunction-associated protein,in human digestive tract", 151, pp.45~54
  16. "Loss of the tight junction MAGUKZO-1 in breast cancer:relationship to glandular differentiation andloss of heterozygosity", 153, pp.1767~73 (1998)
  17. "Identificationand purification of a cell surface glycoprotein mediating intercellularadhesion in embryonic and adult tissue", 34, pp.455~66 (1983)
  18. "Expression of E-cadherin and -catenin in patients with colorectal cancer", 60, pp.524~30 (2001)
  19. "Expression of osteopontinmessenger RNA by macrophages in ovarian serous papillarycystadenocarcinoma:a possible association with calcification of psammomabodies", 50, pp.531~5 (2000)
  20. "The role of osteopontin intumorigenesis and metastasis", 17, pp.1~15 (1997)
  21. "Overexpressionof osteopontin in hepatocellular carcinoma", 52, pp.19~24
  22. "Osteopontin expression ina group of lymph node negative breast cancer patients", 79, pp.502~8
  23. "Dedifferentiation and decreasedexpression of adhesion molecules,E-cadherin and ZO-1,in colorectalcancer are closely related to liver metastasis", 22, pp.117~23 (2003), J Exp Clin CancerRes
  24. "Expression of E-cadherinand alpha-catenin in patients with colorectal carcinoma", 111, pp.29~37 (1999)
  25. "Therole of the cell-cell adhesion molecule E-cadherin in large boweltumour cell invasion and metastasis", 67, pp.904~9 (1993)
  26. "Expression of E-cadherin and -catenin complex in human adenocarcinoma and adenoma of stomachand colon", 36, pp.473~82 (2000)
  27. "Reductionof E-cadherin levels and deletion of the alpha-catenin gene inhuman prostate cancer cells", 53, pp.3585~90 (1993)
  28. "Reduced E-cadherin expression as a causeof distinctive signet-ring cell variant in colorectal carcinoma", 17, pp.23~8 (2002)

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