본문 바로가기
KERD
논문KCI 등재

Survivin and Fas Ligand Expressions Are Correlated with AngiolymphaticTumor Spread in Medullary Thyroid Carcinoma

Survivin and Fas Ligand Expressions Are Correlated with Angiolymphatic Tumor Spread in Medullary Thyroid Carcinoma

김한성|손진희|박성혜|김어진|주미|채승완|박성회|김민경
대한병리학회|2005.10|Journal of Pathology and Translational Medicine|제39권 제5호|pp. 320-325

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : Medullary thyroid carcinoma (MTC) that originates from C cells comprises about 10% of all the malignant thyroid tumors. Activating mutations of the RET proto-oncogene have been found to be involved in the anti-apoptotic pathway of MTC that harbors the RET mutation. We investigated the correlation between the clinicopathologic parameters and the expressions of survivin, a novel anti-apoptotic molecule, and the other apoptosis-related proteins, and the known prognostic markers. Methods : Immunohistochemical staining was performed using antibodies for survivin, Fas, Fas ligand (FasL), bcl-2, calcitonin, CEA and cyclin A in 19 case of MTC; 10 sporadic MTCs, eight multiple endocrine neoplasia (MEN) type 2A MTCs and one familial MTC (FMTC). Results : Survivin protein expression was found in five cases (26%) and this was correlated with the presence of angiolymphatic tumor emboli (p=0.019). FasL was expressed in 14 cases (74%) and it had correlation with the presence of lymph node metastases (p=0.029). The cyclin A-labeling indices were correlated with local invasiveness (p=0.001). Conclusions : Survivin and FasL might be involved in the lymphatic tumor spread of MTC.

참고문헌 (30)

  1. "Pathology of thyroid gland" (2002), Churchill Livingstone
  2. "Tumours of the thyroid and parathyroid Pathology and genetics of tumours of endocrine organs", pp.50~91 (2004), IARC Press
  3. "Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation", 61, pp.4526~35 (2001)
  4. "Primary hereditary medullary thyroid carcinoma--C-cell morphology and correlation with preoperative calcitonin levels", 433, pp.203~8 (1998)
  5. "Early presentation of metastatic medullary carcinoma in multiple endocrine neoplasia,type IIA:implications for therapy", 129, pp.459~64 (1996)
  6. "RET proto-concogene in the development of human cancer", 17, pp.380~93 (1999)
  7. "RET proto-oncogene mutationsare restricted to codon 634 and 618 in Korean families with multipleendocrine neoplasia 2A", 14, pp.813~8 (2004)
  8. "Genome-wide copy number imbalances identified in familial and sporadic medullary thyroid carcinoma", 88, pp.1866~72 (2003)
  9. "A novel anti-apoptosis gene,survivin,expressed in cancer and lymphoma", 3, pp.917~21 (1997)
  10. "IAP family proteins--suppressors of apoptosis", 13, pp.239~52 (1999)
  11. "IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas", pp.5315~20, Cancer Res
  12. "Prognostic value of bcl-2 immunoreactivity in medullary thyroid carcinoma", 26, pp.945~50 (1995)
  13. "Apoptosis and expression of the proto-oncogenes bcl-2 and p53 and the proliferation factor Ki-67 in human medullary thyroid carcinoma", 7, pp.37~45 (1996)
  14. "Fas ligand expression in thyroid carcinomas:a potential mechanism of immune evasion", 84, pp.2924~32 (1999)
  15. "Integrins and anoikis", 9, pp.701~6 (1997), Curr Opin Cell Biol
  16. "Role of lymphocyte adhesion receptors in transient interactions and cell locomotion", 9, pp.27~66 (1991)
  17. "Regulation of lymphocyte survival by the bcl-2 gene family", 13, pp.513~43 (1995)
  18. "Tumor necrosis factor receptor and Fas signalingmechanisms", 17, pp.331~67 (1999)
  19. "Lymphocyte apoptosis induced by CD95 ligand-expressing tumor cells -- a mechanism of immune evasion", pp.1361~6
  20. "Regulation of proliferation and apoptosis in sporadic and hereditary medullary thyroid carcinomas and their putative precursor lesions", 437, pp.256~63 (2000)
  21. "Thyroid carcinoma cells are resistant to Fas-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand", 60, pp.4122~9 (2000)
  22. "The cancer antiapoptosis mouse survivin gene:characterization of locus and transcriptional requirements of basal and cell cycle-dependent expression", 59, pp.3143~51 (1999)
  23. "The inhibitors of apoptosis(IAPs)and their emerging role in cancer", 17, pp.3247~59 (1998)
  24. "Control of apoptosis and mitotic spindle checkpoint by survivin", 396, pp.580~4 (1998)
  25. "Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation", 96, pp.1457~62 (1999)
  26. "High expression of survivin,mapped to 17q25,is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma", 19, pp.617~23 (2000)
  27. "Expression of a novel antiapoptosis gene,survivin,correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas", 58, pp.1808~12 (1998)
  28. "Expression of survivin and its relationship to loss of apoptosis in breast carcinomas", 6, pp.127~34 (2000), Clin Cancer Res
  29. "Inhibition of apoptosis by survivin predicts shorter survival ratesin colorectal cancer", 58, pp.5071~4 (1998), Cancer Res
  30. "A population-based analysis of survival factors in differentiated and medullary thyroid carcinoma", 128, pp.115~23 (2003)

관련 논문AI추천

Detection of Survivin and COX-2 in Thyroid Carcinoma: Anaplastic Carcinoma Shows Overexpression of Nuclear Survivin and Low COX-2 Expression김영아, 김지은, 박영주, 장미수대한병리학회 · Journal of Pathology and Translational Medicine2012 · 제46권 제1호Immunohistochemical Analysis of Insular Carcinoma of the Thyroid Gland민혜숙, 박성회, 백진호, 이경분, 정두현대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제5호Relationships between Lymph Node Metastasis and Expression of CD31, D2-40, and Vascular Endothelial Growth Factors A and C in Papillary Thyroid Cancer김동훈, 김원석, 손진희, 이노희, 이상혁, 이성진, 진성민, 채승완대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2012 · 제5권 제3호Microvessel and Lymphatic Vessel Density and VEGFR-3 Expression of Papillary Thyroid Carcinoma with Comparative Analysis of Clinicopathological Characteristics강한나, 구혜수, 김형경, 배지윤, 성순희, 송동은, 정하린, 조민선, 한운섭대한병리학회 · Journal of Pathology and Translational Medicine2010 · 제44권 제3호Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence김백희, 김애리, 김한겸, 신봉경, 우정수, 이은정, 이재복, 정원경대한병리학회 · Journal of Pathology and Translational Medicine2014 · 제48권 제2호갑상선 유두상 암종에서의 COX-2와 VEGF-C의 발현과 예후인자들과의 관계권순영, 김광일, 백승국, 우정수, 정광윤대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2004 · 제47권 제12호

이 간행물의 다른 논문 (11건)

유방암종에서 E2F4와 E2F2의 발현조현진, 김은영, 이미자pp. 301-306방사선요법으로 치료한 자궁목의 침윤성 편평세포암종에서 HIF-1α 단백 발현성순희, 서현숙, 심기남, 박혜숙, 정성애, 박혜영, 이시내, 김승철, 박수연, 이경은, 문혜성, 조민선, 유은선, 유권, 이경자pp. 307-312Mutational and Loss of Heterozygosity Analysis of the p53 and PTENTumor Suppressor Genes in Breast Carcinoma이영호, 박문일, 김헌수, 나선영, 서광선, 이생금pp. 313-319Immunohistochemical Analysis of Insular Carcinoma of the Thyroid Gland이경분, 민혜숙, 박성회, 정두현, 백진호pp. 326-331비호지킨 림프종에서 DNA Topoisomerase Iiα, Ki-67, p53및 p27 발현변화설미영, 김지연, 강현정, 신동훈, 이경민, 최경운, 김활웅, 박도윤, 이창훈pp. 332-337
원문 보기