갑상선 유두상 암종에서의 COX-2와 VEGF-C의 발현과 예후인자들과의 관계
Prognostic Significance of COX-2 and VEGF-C Expression in Thyroid Papillary Carcinoma
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Abstract
Background and Objectives：Cycloxygenase-2 (COX-2) may play a role in tumor growth and spread of numerous types of epithelial cancers since it can regulate tumor angiogenesis by modulating the production of several angiogenic factors, including vascular endothelial growth factor (VEGF). We investigated the corelation between COX-2 and VEGF-C expresions and diferent prognostic factors of thyroid papillary carcinoma. Subjects and Method：Thirty-eight patients with thyroid papillary semiquantitative scoring method was employed to determine their expression levels. The imunostaining scores were compared with diferent prognostic factors of thyroid papillary carcinoma. Results：The mean scores± SD for COX-2 and VEGF-C were 3.9± 3.6 and 4.7± 3.1, respectively, and there was a significant corelation between their expressions. Among the prognostic factors of thyroid papilary carcinoma, age, sex, and tumor size made no significant diferences betwen COX-2 and VEGF-C with nodal metastasis and extracapular spread. Conclusion：Nodal metastasis, tumor stage, and extracapsular spread were found to be associated with the expressions of COX-2 and VEGF-C, and were concerned with the growth and metastasis of tumor. Therefore, COX-2 and VEGF-C may play important roles in the tumor growth and metastasis of thyroid papilary carcinoma, as in other epithelial cancers.
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