본문 바로가기
KERD
논문KCI 등재

외과적으로 절제한 폐의 편평세포암종과 샘암종에서Anaphase Promoting Complex의 발현

Expression of Anaphase Promoting Complex in Surgically Resected Squamous Cell Carcinoma and Adenocarcinoma of the Lung

김호영|정순희|이상엽|엄민섭|강엽|박광화|송지선
대한병리학회|2006.02|Journal of Pathology and Translational Medicine|제40권 제1호|pp. 52-59

1

조회

0

다운로드

0

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : The anaphase promoting complex (APC) promotes the degradation of mitotic cyclins as well as other substrates involved in sister chromatid adhesion. This study was carried out to examine the relationship between the APC expression and the clinicopathological variables, in an attempt to determine the role of the APC in the proliferation of lung cancer and to evaluate the possibility of an aberrant APC function in surgically resected squamous cell carcinomas and adenocarcinomas of the lung. Methods : Immunohistochemical staining was performed for APC, Ki-67, cyclin B1, Cdc2, MMP-2 and VEGF in 55 cases of squamous cell carcinoma and 34 cases of adenocarcinoma of the lung, using the avidin-biotin-peroxidase method. Results : The immunohistochemical stains for APC revealed a positive reaction in 49 cases (55.1%). The APC expression level was higher in the cyclin B1-positive group (p=0.01), the Cdc2-positive group (p=0.001), the MMP-2-positive group (p=0.03), the group with lymph node metastasis (61.4% vs 48.9%), and the group with stage II/III cancer (60.7%) compared with those with stage I (42.9%). Conclusions : The APC may have an aberrant function, such as a change in its role in controlling the cell cycle, and might be associated with the invasiveness and proliferation of tumor cells.

참고문헌 (30)

  1. "Principles of CDK regulation", 374, pp.131~134 (1995)
  2. "Regulation of the APC and the exit from mitosis", 1, pp.47~53 (1999)
  3. "Inhibitors of mammalian G1 cyclin-dependent kinases", 9, pp.1149~1163 (1995)
  4. "Whose end is destruction:cell division and anaphase-promoting complex", 13, pp.2039~2058 (1999)
  5. "The anaphase promoting complex", 29, pp.133~150 (1997)
  6. "The cyclosome,a large complex containing cyclin-selective ubiquitin ligase activity,targets cyclins for destruction at the end of mitosis", 6, pp.185~197 (1995)
  7. "A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B", 81, pp.279~288 (1995)
  8. "The anaphase-promoting complex:new subunits and regulators", 68, pp.583~609 (1999)
  9. "Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9)type IV collagenases in colorectal cancer", 56, pp.190~196 (1996)
  10. "Expression of matrix metalloproteinase(gelatinase)in T1 adenocarcinoma of the lung", 47, pp.461~469 (1997)
  11. "The biology of vascular endothelial growth factors", 65, pp.550~563 (2005)
  12. "The biology of vascular endothelial growth factor", 18, pp.4~25 (1997)
  13. "Increased expression of vascular permeability factor(vascular endothelial growth factor)and its receptors in kidney and bladder carcinomas", 143, pp.1255~62 (1993)
  14. "Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis", 54, pp.4233~7 (1994)
  15. "Strong expression of vascular permeability factor(vascular endothelial growth factor)and its receptors in ovarian borderline and malignant neoplasms", 74, pp.1105~1115 (1996)
  16. "Expression of vascular endothelial growth factor,its receptor,and other angiogenic factors in human breast cancer", 56, pp.2013~2016 (1996)
  17. "Immunohistochemical study on tumor angiogenic factors in non-small cell lung cancer", 19, pp.4305~4309 (1999)
  18. "Tumor angiogenesis and recurrence in stage I non-small cell lung cancer", 68, pp.1034~1038 (1999)
  19. "Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma", 73, pp.931~934 (1996)
  20. "The Ki-67 protein:fascinating forms and an unknown function", 257, pp.231~237 (2000)
  21. "Relationship between expression of anaphase-promoting complex and prognostic factors in invasive ductal carcinoma of breast", 37, pp.19~25 (2003)
  22. "Alterations of anaphasepromoting complex genes in human colon cancer cells", 22, pp.1486~1490 (2003)
  23. "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex:model for spindle checkpoint regulation", 21, pp.5190~5199 (2001)
  24. "Expression of cyclin B1 and cdc2 in nodal non-Hodgkin’s lymphoma and its prognostic implications", 17, pp.322~327 (2002)
  25. "Overexpression of cyclin B1 in earlystage non-small cell lung cancer and its clinical implication", 60, pp.4000~4004 (2000)
  26. "Cyclin B1,unlike cyclin G1,increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes", 22, pp.1101~1110 (2003)
  27. "Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer", 12, pp.717~723 (2004)
  28. "Effect of cyclooxygenase-2,and matrix metalloproteinase-2 expression on prognosis of lung cancer", 23, pp.1190~1193 (2004)
  29. "Angiogenesis and lung cancer:prognostic and therapeutic implications", 23, pp.3243~3256 (2005)
  30. "Characterisation of the human APC1,the largest subunit of the anaphasepromoting complex", 262, pp.51~59 (2001)

관련 논문AI추천

유방의 침윤성 관암종에서 Anaphase-promoting Complex의 발현과 예후 인자와의 관계강엽, 박광화, 엄민섭, 이광길, 이상엽, 정순희대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제1호파제트병과 동반된 유방암에서 Anaphase Promoting Complex (APC)와 APC조절 단백의 발현강엽, 박광화, 양우익, 이광길, 이상엽대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제5호비소세포폐암종에서 c-kit와 세포주기 조절인자의 발현주미, 김한성, 장선희대한병리학회 · Journal of Pathology and Translational Medicine2006 · 제40권 제6호비소세포 폐암종에서 Survivin의 발현 - 예후 및 종양 표지자와의 상관성-정민정, 천봉권대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제3호폐암에서 p63의 발현김정연, 박경미, 임성직대한병리학회 · Journal of Pathology and Translational Medicine2003 · 제37권 제2호비소세포 폐암종의 상피성장인자 수용체 상태와 임상-병리학적 연관성: 단백 발현, 유전자 증폭 및 생존분석최진, 이승구, 장세진대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제6호

이 간행물의 다른 논문 (11건)

담관암종에서 14-3-3 단백의 발현과 14-3-3 유전자의 메틸화이영주, 박혜정, 이승규, 이상수, 송동은, 심용희, 장세진, 유은실, 김명환, 김정선pp. 9-16비소세포 폐암종의 CD44s 와 Cycylooxygenase-2 발현김현정, 김정연, 박경미, 임성직pp. 17-23비소세포폐암종에서 Cyclin E 경로 단백들(cyclin E, cdk2,p21, p27, p57)의 발현 및 예후 지표 인자로서 의의정지한, 정찬권, 심상인, 이교영, 강창석, 변재호, 이명아, 이희정, 박경신pp. 24-31위생검 조직에서 비정형 점막병변에 대한 GLUT1과 p53의 발현도인구, 박용구, 김윤화pp. 32-38신세포암종에서 Heat Shock Protein 27의 발현과 세포자멸사에 대한 연구윤길숙pp. 39-45
원문 보기