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논문KCI 등재

비소세포 폐암종의 상피성장인자 수용체 상태와 임상-병리학적 연관성: 단백 발현, 유전자 증폭 및 생존분석

Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: ProteinExpression, Gene Amplification and Survival Analysis

최진|장세진|이승구
대한병리학회|2007.12|Journal of Pathology and Translational Medicine|제41권 제6호|pp. 387-392

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참고문헌

주제분류병리학

초록

Abstract

Background : Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein expression and gene amplification, and the correlation between EGFR status and survival in NSCLC. Methods : We examined 360 cases of microarrayed NSCLC tissues for the EGFR protein expression and EGFR gene amplification using immunohistochemistry and fluorescent in situ hybridization. Results : EGFR protein expression and EGFR gene amplification occurred in 110 cases (30.6%) and 24 cases (6.7%), respectively. EGFR protein expression and gene amplification were more frequent in squamous cell carcinoma than in adenocarcinoma. Differences in EGFR protein expression did not dramatically affect survival curves (p=0.740), but differences in gene amplification did (p<0.05): EGFR gene amplification was associated with a lower 5-year survival rate. Conclusion : EGFR protein expression and gene amplification showed moderate correlation with each other. EGFR gene amplification predicted a poor prognosis, whereas EGFR protein expression did not.

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관련 논문AI추천

비소세포폐암종에서 EGFR 단백 발현과 유전자 증폭이제피티닙 치료에 미치는 영향강석진, 김성환, 김치홍, 김훈교, 심병용, 안명임, 유진영, 이경지, 정지한, 조규도, 조덕곤대한병리학회 · Journal of Pathology and Translational Medicine2008 · 제42권 제1호비소세포암종의 Epidermal Growth Factor Receptor발현과 EGFR 돌연변이와의 관계김미진, 석상희대한병리학회 · Journal of Pathology and Translational Medicine2008 · 제42권 제2호면역조직화학적 염색 방법에 따른 상피세포 성장 수용체 단백(EGFR)의 발현정도의 차이 및 EGFR의 발현정도와 EGFR 유전자의 돌연변이와의 상관관계에 대한 고찰김극준, 김상희, 김현용, 석상희, 송호정, 윤인숙, 이은화, 이태종대한임상검사과학회 · 대한임상검사과학회지2007 · 제39권 제3호비소세포 폐암종에서 Survivin의 발현 - 예후 및 종양 표지자와의 상관성-정민정, 천봉권대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제3호Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey김교영, 김미진, 김완섭, 김한겸, 노미숙, 서정욱, 성순희, 오미혜, 이건국, 이교영, 이상화, 이창훈, 장세진, 장순희, 정순희, 최유덕, 한정호, 김루시아대한병리학회 · Journal of Pathology and Translational Medicine2015 · 제49권 제6호초기단계의 비소세포폐암종에서 Telomerase ReverseTranscriptase 단백발현이 예후지표인자로서 가지는 의의박경신, 유진영, 이교영, 이아원, 정지한, 정찬권대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제2호

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