본문 바로가기
KERD
논문KCI 등재

비소세포폐암종에서 Galectin-3 단백 발현의 의의

Significance of Galectin-3 Expression in Pulmonary Non-Small Cell Carcinoma

강현정|이창훈|이민기|설미영|신동훈
대한병리학회|2006.10|Journal of Pathology and Translational Medicine|제40권 제5호|pp. 326-332

1

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

Abstract

Background : Non-small cell carcinoma (NSCC) has become the leading cause of cancer related death around the world. However, its prognostic factors remain poorly defined. Galectin-3 is an apoptosis related protein and its relationship with various cancers is presently the subject of research. This study was performed to investigate galectin-3 expression in NSCC and its value as a prognostic factor. Methods : We examined the expression of galectin-3 and bcl-2 in surgically resected, lung NSCC, including 61 squamous cell carcinomas and 41 adenocarcinomas. PCNA staining was also performed. Results : Each type of carcinoma showed cytoplasmic positivity in 18 (30.0%) and 25 (61.0%) cases, respectively. Squamous cell carcinoma showed increased galectin-3 expression in better differentiated tumors, whereas adenocarcinoma didn’t show any relationship with the degree of differentiation. The cytoplasmic positivity of galectin-3 in both types of carcinoma was associated with poor prognosis. Bcl-2 expression didn’t show any significant relationship with overall survival. Galectin-3 and bcl-2 expressions were positively correlated. However, co-expression of both proteins was not related to prognosis. Conclusions : These results indicate that galectin-3 expression in NSCC warrants attention as a possible prognostic factor.

참고문헌 (25)

  1. "Galectins:A family of animal beta-galactoside-binding lectins", 76, pp.597~8 (1994)
  2. "Oligosaccharide specificity of galectins:a search by frontal affinity chromatography", 1572, pp.232~254 (2002)
  3. "Intracellular functions of galectins", 1572, pp.263~273 (2002)
  4. "Galectins:versatile modulators of cell adhesion,cell proliferation,and cell death", 76, pp.402~412 (1998)
  5. "Galectins and cancer", 1572, pp.285~293 (2002)
  6. "Mac-2:a versatile galactose-binding protein of mammalian tissues", 4, pp.5~12 (1994)
  7. "Endogenous lectins from cultured cells:nuclear localization of carbohydrate-binding protein 35 in proliferating 3T3 fibroblasts", 84, pp.6452~6 (1987)
  8. "Secretion of the galectin family of mammalian carbohydrate-binding proteins", 1473, pp.172~185 (1999)
  9. "Galectin-3 and carcinoembryonic antigen expression in medullarythyroid carcinoma:possible relation to tumour progression", 37, pp.530~535 (2000)
  10. "Increased galectin-3 expression in gastric cancer:correlations with histopathological subtypes,galactosylated antigens and tumor cell proliferation", 21, pp.258~266 (2000)
  11. "Localization of galectin-3 in normal and diseased pancreatic tissue", 23, pp.1~9 (1998)
  12. "Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma", 6, pp.4635~4640 (2000)
  13. "Expression of the 67-kD laminin receptor,galectin-1,and galectin-3 in advanced human uterine adenocarcinoma", 27, pp.1185~1191 (1996)
  14. "Decreased expression of galectin-3 is associated with progression of human breast cancer", 179, pp.43~48 (1996)
  15. "2004년 사망원인통계결과", 14 (2005)
  16. "Galectin-3 expression in nonsmall cell lung carcinoma", 212, pp.233~239 (2004)
  17. "Galectin-3:differential expression between small-cell and non-small-cell lung cancer", 44, pp.339~344 (2004)
  18. "Nuclear galectin-3 expression is an independent predictive factor of recurrence for adenocarcinoma and squamous cell carcinoma of the lung", 18, pp.1264~1271 (2005)
  19. "Galectin-3:a novel antiapoptotic molecule with a functional BH1(NWGR)domain of Bcl-2 family", 57, pp.5272~5276 (1997)
  20. "Expression of galectin-3 modulates T-cell growth and apoptosis", 96, pp.6737~6742 (1996)
  21. "Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells", 59, pp.4148~4154 (1999)
  22. "CD29 and CD7 mediategalectin-3-induced type II T-cell apoptosis", 63, pp.8302~8311 (2003)
  23. "Role of galectin-3 in breast cancer metastasis:involvement of nitric oxide", 160, pp.1069~1075 (2002)
  24. "Role of Bcl-2 as a prognostic factor for survival in lung cancer:a systematic review of the literature with meta-analysis", 89, pp.55~64 (2003)
  25. "Concentrations of galectin-3 in the sera of normal controls and cancer patients", 6, pp.1389~1393 (2000)

관련 논문AI추천

비소세포 폐암종에서 Survivin의 발현 - 예후 및 종양 표지자와의 상관성-정민정, 천봉권대한병리학회 · Journal of Pathology and Translational Medicine2005 · 제39권 제3호갑상선 종양에서 Galectin-3 발현의 임상적 의의김진환, 노영수, 신형식, 안회영, 오소정, 조성진, 한동혁대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2006 · 제49권 제8호초기단계의 비소세포폐암종에서 Telomerase ReverseTranscriptase 단백발현이 예후지표인자로서 가지는 의의박경신, 유진영, 이교영, 이아원, 정지한, 정찬권대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제2호비소세포폐암종에서 CD44s, CD44v5 및 CD44v6 발현의 임상병리학적 의의김재균, 송진미, 이경민, 이창훈대한병리학회 · Journal of Pathology and Translational Medicine2004 · 제38권 제2호비소세포폐암종에서 p73의 발현강석진, 박경신, 유진영, 이교영, 정지한, 정찬권, 최현주대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제2호비소세포 폐암종의 상피성장인자 수용체 상태와 임상-병리학적 연관성: 단백 발현, 유전자 증폭 및 생존분석최진, 이승구, 장세진대한병리학회 · Journal of Pathology and Translational Medicine2007 · 제41권 제6호

이 간행물의 다른 논문 (12건)

대장암에서 M30 면역 염색으로 검출된 세포 자멸사와 MSI및 임상 병리학적 특징과의 상관 관계허기영, 김활웅, 최경운, 강현정, 신동훈, 김지연, 이창훈, 이수한, 설미영, 박도윤pp. 319-325N-butyl-N-(4-hydroxybutyl)nitrosamine으로 유도된 흰쥐의 방광암 발생과정에서 Survivin, HSP90, Bcl-2, Bax 단백의 발현권귀영, 이상대, 박성웅, 이태진, 홍순억pp. 333-338Genistein 에 의한 B35 신경모세포종 세포의, 세포자멸사유도 및 세포주기 정지; p21waf1/cip1, Bax와 Bcl-2의 관련손윤경, 김정완, 강구성, Ismail A. Ismailpp. 339-347특발성 문맥압 항진증 8예의 임상 및 병리학적 분석김경모, 김경은, 임영석, 유은실pp. 348-353백서 N-nitrosomorpholine Stop Experiment시 발생하는간세포 종양과 전구병변에서의 PDGF-Rα 발현김수진, 김경태, 정진숙pp. 354-360
원문 보기