Myxoid Liposarcoma with Cartilaginous Differentiation: A Case Study with Cytogenetical Analysis
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Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.
Abstract
Myxoid liposarcoma is a subtype of liposarcoma. This specific subtype can be identified based on its characteristic histological and cytogenetical features. The tumor has a fusion transcript of the CHOP and TLS genes, which is caused by t(12;16)(q13;p11). Most of the fusion transcripts that have been identified fall into three categories, specifically type I (exons 7-2), type II (exons 5-2), and type III (exons 8-2). A total of seven myxoid liposarcomas associated with the rare phenomenon of cartilaginous differentiation have been documented in the literature. Currently, only one of these cases has been cytogenetically analyzed, and the analysis indicated that it was a type II TLS-CHOP fusion transcript in both the typical myxoid liposarcoma and cartilaginous areas. This study presents a second report of myxoid liposarcoma with cartilaginous differentiation, and includes a cytogenetical analysis of both the myxoid and cartilaginous areas.
참고문헌 (20)
- Evans HL, "Liposarcoma: a study of 55 cases with a reassessment of its classification", Am J Surg Pathol, 3, pp.507~523 (1979)
- Weiss SW, "Enzinger and Weiss’s soft tissue tumors" (2008), Mosby Elsevier
- Kilpatrick SE, "The clinicopathologic spectrum of myxoid and round cell liposarcoma: a study of 95 cases", Cancer, 77, pp.1450~1458 (1996)
- Enzinger FM, "Liposarcoma: a study of 103 cases", Virchows Arch Pathol Anat Physiol Klin Med, 335, pp.367~388 (1962)
- Dijkhuizen T, "Cytogenetic analysis of a case of myxoid liposarcoma with cartilaginous differentiation", Cancer Genet Cytogenet, 92, pp.141~143 (1996)
- Shanks JH, "Focal rhabdomyosarcomatous differentiation in primary liposarcoma", J Clin Pathol, 49, pp.770~772 (1996)
- Siebert JD, "Myxoid liposarcoma with cartilaginous differentiation", Mod Pathol, 9, pp.249~252 (1996)
- Govender D, "Primary myxoid liposarcoma with rhabdomyoblastic differentiation", Arch Pathol Lab Med, 122, pp.740~742 (1998)
- Wei YC, "Myxoid liposarcoma with cartilaginous differentiation: identification of the same type II TLS-CHOP fusion gene transcript in both lipogenic and chondroid components", Appl Immunohistochem Mol Morphol, 15, pp.477~480 (2007)
- Hisaoka M, "Detection of TLS", FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues, 1998, pp.7, 96~101
- Antonescu CR, "Prognostic impact of p53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases", Clin Cancer Res, 7, pp.3977~3987 (2001)
- Fletcher CD, "World Health Organization calssification of tumours: pathology and genetics of tumours of soft tissue and bone" (2002), IARC Press
- Limon J, "Recurrent chromosome translocations in liposarcoma", Cancer Genet Cytogenet, 22, pp.93~94 (1986)
- Aman P, "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13; p11)", Genes Chromosomes Cancer, 5, pp.278~285 (1992)
- Crozat A, "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma", Nature, 363, pp.640~644 (1993)
- Rabbitts TH, "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma", Nat Genet, 4, pp.175~180 (1993)
- Nishio J, "Cytogenetics and molecular genetics of myxoid soft-tissue sarcomas", Genet Res Int, 2011, pp.497148~ (2011)
- Panagopoulos I, "A novel FUS", CHOP chimera in myxoid liposarcoma, 2000, pp.279, 838~845
- Dei Tos AP, "Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma", Am J Pathol, 151, pp.1531~1539 (1997)
- Smith TA, "Myxoid", round cell liposarcoma of the extremities: a clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma, 1996, pp.20, 171~180