Cytopathologic Features of Secretory Carcinoma of Salivary Gland: Report of Two Cases
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Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-year-old male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.
Abstract
Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-year-old male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions. The tumor cells demonstrated uniform, round, smooth nuclear contours and distinct nucleoli. Multiple characteristic cytoplasmic vacuoles were revealed. Singly scattered tumor cells frequently showed variable sized cytoplasmic vacuoles. The cytopathologic diagnosis of SC should be considered when characteristic cytological findings are revealed. Further immunohistochemistry and gene analyses are helpful to diagnose SC.
참고문헌 (12)
- Skalova A, "Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene : a hitherto undescribed salivary gland tumor entity", Am J Surg Pathol, 34, pp.599~608 (2010)
- Skalova A., "Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity", Head Neck Pathol, 7(Suppl 1), pp.S30~S36 (2013)
- Parekh V, "Mammary analogue secretory carcinoma", Arch Pathol Lab Med, 140, pp.997~1001 (2016)
- Boon E, "Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed(mammary analogue)secretory carcinoma of salivary glands", Oral Oncol, 82, pp.29~33 (2018)
- Sethi R, "Mammary analogue secretory carcinoma : update on a new diagnosis of salivary gland malignancy", Laryngoscope, 124, pp.188~195 (2014)
- El-Naggar AK, "WHO classification of head and neck tumours" (2017), International Agency for Research on Cancer
- Bishop JA, "Cytopathologic features of mammary analogue secretory carcinoma", Cancer Cytopathol, 121, pp.228~233 (2013)
- Seethala RR, "Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of the salivary gland", Head Neck Pathol, 11, pp.55~67 (2017)
- Chiosea SI, "Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands", Histopathology, 61, pp.387~394 (2012)
- Skálová A, "Mammary analogue secretory carcinoma of salivary glands with high-grade transformation : report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, beta-catenin, EGFR, and CCND1 genes", Am J Surg Pathol, 38, pp.23~33 (2014)
- Luo W, "Mammary analog secretory carcinoma of salivary gland with high-grade histology arising in hard palate, report of a case and review of literature", Int J Clin Exp Pathol, 7, pp.9008~9022 (2014)
- Jung MJ, "Aspiration cytology of mammary analogue secretory carcinoma of the salivary gland", Diagn Cytopathol, 43, pp.287~293 (2015)