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Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lung

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Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC). Methods: We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells. Results: The positive staining of S100A8 in tumor cells was significantly increased in male (p < .001), smoker (p = .034), surgical method other than lobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022) compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. The proportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patient sex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patient age (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlated with patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumor cells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cells stained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCC but towards decreased survivability in ADC. Conclusions: S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.

Abstract

Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC). Methods: We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells. Results: The positive staining of S100A8 in tumor cells was significantly increased in male (p < .001), smoker (p = .034), surgical method other than lobectomy (p = .024), squamous cell carcinoma (SQCC) (p < .001) and higher TNM stage (p = .022) compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. The proportion of tumor cells stained for S100A8 was related to histologic type (p < .001) and patient sex (p = .027). The proportion of inflammatory cells stained for S100A8 was correlated with patient age (p = .022), whereas the proportion of inflammatory cells stained for S100A9 was correlated with patient sex (p < .001) and smoking history (p = .031). Moreover, positive staining in tumor cells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cells stained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCC but towards decreased survivability in ADC. Conclusions: S100A8 and S100A9 expressions might be potential prognostic markers in patients with NSCLC.

참고문헌 (35)

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