Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma
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Background: Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease. Methods: Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups. Results: Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively. Conclusions: A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.
Abstract
Background: Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease. Methods: Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups. Results: Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively. Conclusions: A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.
참고문헌 (23)
- Batsakis JG, "Primary squamous cell carcinomas of major salivary glands", Ann Otol Rhinol Laryngol, 92(1 Pt 1), pp.97~98 (1983)
- Chen MM, "Prognostic factors for squamous cell cancer of the parotid gland : an analysis of 2104 patients", Head Neck, 37, pp.1~7 (2015)
- Flynn MB, "Primary squamous cell carcinoma of the parotid gland : the importance of correct histological diagnosis", Ann Surg Oncol, 6, pp.768~770 (1999)
- Manvikar V, "Squamous cell carcinoma of submandibular salivary gland : a rare case report", J Oral Maxillofac Pathol, 18, pp.299~302 (2014)
- Panchbhai AS, "Primary squamous cell carcinoma of salivary gland : report of a rare case", J Cancer Res Ther, 11, pp.664~ (2015)
- Taxy JB, "Squamous carcinoma in a major salivary gland : a review of the diagnostic considerations", Arch Pathol Lab Med, 125, pp.740~745 (2001)
- Williams L, "Salivary duct carcinoma : the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression", Am J Surg Pathol, 39, pp.705~713 (2015)
- Alsahafi E, "Clinical update on head and neck cancer : molecular biology and ongoing challenges", Cell Death Dis, 10, pp.540~ (2019)
- Zhou G, "TP53 mutations in head and neck squamous cell carcinoma and their impact on disease progression and treatment response", J Cell Biochem, 117, pp.2682~2692 (2016)
- Wolff AC, "HER2 testing in breast cancer : American Society of Clinical Oncology", College of American Pathologists clinical practice guideline focused update summary, 2018, pp.14, 437~441
- Glisson B, "HER2 expression in salivary gland carcinomas : dependence on histological subtype", Clin Cancer Res, 10, pp.944~946 (2004)
- Xu B, "A proportion of primary squamous cell carcinomas of the parotid gland harbour high-risk human papillomavirus", Histopathology, 69, pp.921~929 (2016)
- Gallego L, "Bilateral carcinoma in situ of Wharton's duct after chronic obstructive sialadenitis:inflammation as the cause of malignancy?", Ann Otol Rhinol Laryngol, 121, pp.296~300 (2012)
- Franzen A, "The heterogenicity of parotid gland squamous cell carcinoma : a study of 49 patients", In Vivo, 33, pp.2001~2006 (2019)
- Bron LP, "Primary and metastatic cancer of the parotid : comparison of clinical behavior in 232cases", Laryngoscope, 113, pp.1070~1075 (2003)
- Kulkarni AA, "Primary squamous cell carcinoma of submandibular salivary gland with sialo-cutaneous fistula : a rare case report", J Clin Diagn Res, 9, pp.PD03~PD05 (2015)
- Kapadia SB, "Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma", Mod Pathol, 11, pp.1033~1038 (1998)
- Can NT, "Expression of hormone receptors and HER-2 in benign and malignant salivary gland tumors", Head Neck Pathol, 12, pp.95~104 (2018)
- Dalin MG, "Androgen receptor signaling in salivary gland cancer", Cancers (Basel), 9, pp.17~ (2017)
- Nasser SM, "Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors : frequent expression of androgen receptor in a subset of malignant salivary gland tumors", Am J Clin Pathol, 119, pp.801~806 (2003)
- Udager AM, "Salivary duct carcinoma : an update on morphologic mimics and diagnostic use of androgen receptor immunohistochemistry", Head Neck Pathol, 11, pp.288~294 (2017)
- Agarwal M, "Primary squamous cell carcinoma of submandibular salivary gland : a case report", J Clin Diagn Res, 11, pp.XD01~XD02 (2017)
- Gaikwad RV, "Primary squamous cell carcinoma of the submandibular salivary gland : a rare entity", J Maxillofac Oral Surg, 14(Suppl 1), pp.57~59 (2015)