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가토 두개골에서 β-TCP와 자가골 이식에 관한 실험적 연구

The experimental study of the bone regeneration on β-TCP in rabbit cranial bone

한지영|송승일|심광섭|황경균|백승삼|이성훈
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2004.08|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제30권 제4호|pp. 282-291

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참고문헌

주제분류치의학

초록

Abstract

Pure-phase beta-tricalcium phosphate(β-TCP) proved to be a bone regeneration material, providing the patient with vital bone at the defect site in a reasonable time, making a second surgical procedure for bone harvesting unnecessary. This study compares bone healing and BMP 2/4 expression in cranial defects in rabbits grafted with autogenous bone and β-TCP. Thirty New Zealand White rabbits was divided into 3 group of 10 animals each. Bilateral calvarial defects were made in the parietal bones of each animal. β-TCP placed in one defect and the other defects was filled with autogenous bone. The animal were sacrificed at 4, 8 and 12 weeks. Immunohistochemical analysis was used to investigate the expression of BMP 2/4. 1. The new bone formation around autogenous bone from 4 weeks and β-TCP from 8 weeks. 2. In autogenous bone graft, BMP 2/4 expression was decreased from 4 to 12 weeks 3. In β-TCP graft, BMP 4 expression was increased from 8 to 12 weeks. But, BMP 2 was observed from 12 weeks. This study showed that bone healing, regeneration and, BMP 2/4 expression are delayed in grafted β-TCP than autogenous bone.

참고문헌 (26)

  1. "Nature history of autograft and allograft", pp.7~16 (1987)
  2. "Quantitative camparision of healing in cranial fresh autografts and allografts in canine skull defects", pp.269~291 (1986)
  3. "Bony healing of large cranial and mandibular defects protected from soft tissue interposition a comparative study of spontaneous bone regeneration and cancellous autografting in dogs", 101, pp.660~672 (1998)
  4. "Assessment of the value of anorganic bone additives in sinus floor augmentation a review of clinical reports", 32, pp.1~6 (2003)
  5. "Sinus floor augmentation with beta-tricalciumphosphate does platelet-rich plasma promote its osseous integration and degradation?", 14, pp.213~218 (2003)
  6. "Histologic effect of pure-phase beta-tricalcium phosphate on bone regeneration in human artificial jawbone defects", 23, pp.69~77 (2003)
  7. "Autogenous bone versus β-tricalcium phosphate graft alone for bilateral sinus elevations 2-and 3-dimensional compute tomographic, histologic,and histomorphometric evaluations : preliminary results", 16, pp.681~692 (2001)
  8. "Biology of bone induction and its clinical applications", pp.739~753
  9. "The effect of two delivery systems for recombinant human bone morphogenic protein-2 on periodontal regeneration in vivo", 66, pp.131~138 (1995)
  10. "The effects of bone morphogenic protein-2 4 and 6 on differentiation of rat osteoblastic cell in vitro", 136, pp.2671~2677 (1995)
  11. "Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function. Biomaterials", 20, pp.2287~2303 (1999)
  12. "Resorption patterns of calcium-phosphate cements in bone", pp.532~540 (2003)
  13. "Histological examination of beta-tricalcium phosphate graft in human femur", 63, pp.601~604 (2002)
  14. "Comparative study of tissue reactions to calcium phosphate ceramics among cancellous and medullar bone sites in rabbits", 42, pp.357~367 (1998)
  15. "The biodegradation mechanism of calcium phosphate biomaterials in bone", 63, pp.408~412 (2002)
  16. "Degradation characteristics of alpha and beta tri-calcium-phosphate in minipigs", 63, pp.115~121 (2002)
  17. "Intraindividual comparative animal study of α-and β-tricalcium phospahte degradation in conjunction with simultaneous insertion of dental implants", 12, pp.59~68 (2001)
  18. "Properties of calcium phosphate ceramics in relation to their in vivo behavior", 48, pp.179~186 (2000)
  19. "Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite", β-tricalcium phosphate ratios, 1997, pp.18, 1037~1041
  20. "Osteoclatic resorption of biphasic calcium phosphate ceramic in vitro", 37, pp.346~352 (1997)
  21. "Mechanical activation and cement formation of β-tricalcium phosphate", 24, pp.4123~4131 (2003)
  22. "Regeneration of fracturerepair by growth factors", pp.165~170 (2000)
  23. "In vitro osteoclast resorption of bone substitute biomaterials used for implant site augmentation : A pilot study", 17, pp.321~330 (2002)
  24. "Bone colonization of β-TCP granules incorporated in brushite cements", 63, pp.413~417 (2002)
  25. "BMP signaling components are expressed in human fracture callus", 33, pp.362~371 (2003)
  26. "Endogenous bone morphogenic protein immunohistochemical localization in repair of a punch hole in the rabbit's ear", 99, pp.1382~1389 (1997)

관련 논문AI추천

가토 상악동에 이식된 β-TCP의 골치유에 관한 실험적 연구마평수, 박정하, 박창주, 백승삼, 심광섭, 최용수, 황경균대한구강악안면외과학회 · 대한구강악안면외과학회지2006 · 제32권 제2호가토 두개골 결손부에 이식된 새로운 합성 골이식재의 골치유능력김경욱, 김철환, 노규섭, 한세진대한구강악안면외과학회 · 대한구강악안면외과학회지2007 · 제33권 제5호토끼의 두개골내에 형성된 골결손부에서 HA/ß-TCP composite powders의 골형성에 관한 조직학적 연구김병옥, 김종관, 김흥중, 박주철, 이광호, 장현선대한치주과학회 · Journal of Periodontal & Implant Science2006 · 제36권 제1호가토 두개골 결손부에 이식된 .-TCP의 골치유과정에서맥동전자기장의 영향에 관한 연구김상우, 박창주, 백승삼, 심광섭, 임병섭, 정일혁, 황경균대한구강악안면외과학회 · 대한구강악안면외과학회지2006 · 제32권 제4호백서 두개골 결손부에서 Ca-P 피복된 이종골의 골재생 효과김영준, 김옥수, 박홍주, 성선주, 정현주대한치주과학회 · Journal of Periodontal & Implant Science2004 · 제34권 제3호가토의 두개골 결손부에서 골재생에 끼치는 골막의 역할김병옥, 김상목, 박주철, 장현선대한치주과학회 · Journal of Periodontal & Implant Science2005 · 제35권 제4호

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