본문 바로가기
KERD
논문KCI 등재

가토 두개골 결손부에 이식된 .-TCP의 골치유과정에서맥동전자기장의 영향에 관한 연구

The effect of pulsed electromagnetic fields on β-TCP graft in rabbit cranial bone defect

박창주|심광섭|황경균|백승삼|임병섭|정일혁|김상우
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2006.08|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제32권 제4호|pp. 360-373

0

조회

0

다운로드

0

인용

0

참고문헌

주제분류치의학

초록

Abstract

The purpose of this research was to investigate whether pulsed electromagnetic field (PEMF) stimulation applied to the rabbit cranial defects grafted with β-tricalcium phosphate (β-TCP) could affect the new bone formation. With 16 New Zealand white rabbits under the same condition, bilateral calvarial bone defects were formed around the sagittal suture line. The defect on the left side was grafted with β-TCP, while on the right side was grafted by harvested autogenous bone. PEMF was applied to 8 rabbits for 8 hours per day. The bony specimen were divided into 3 groups, the group 1 was autogenous bone grafted specimen, the group 2 was β-TCP grafted with PEMF, and the group 3 was β-TCP grafted without PEMF. We investigated the bone regeneration & growth factor expression at 2, 4, 6, and 8 weeks. As a result, BMP 2 was expressed in the group 1 from 2 weeks, the group 2 from 4 weeks, and the group 3 from 6 weeks. BMP 4 was expressed in the group 1 from 2 weeks, in the group 2 and the group 3 from 4 weeks. 4. There was no significant difference in expression pattern of BMP 7, PDGF, VEGF, and TGF-β1 during grafted bone regeneration in group 1, 2, and 3. According to our results, PEMF stimulation could be effective on the new bome formation in animal study, and have a feasibility of clinical use.

참고문헌 (36)

  1. "Bone Graft Substitutes", pp.180~187 (2003), ASTM International
  2. "Intraindividual Comparative animal Study of α-and β-Tricalcium Phosphate Degradation in Conjunction with Simultaneous Insertion of Dental Implants", 12, pp.59~68 (2001)
  3. "Autogenous Bone Versus β-Tricalcium Phosphate Graft Alone for Bilateral Sinus Elevations(2-and 3-Dimensional Computed Tomographic, Histologic, and Histomorphometric Evaluations) Preliminary Results", 16, pp.681~692 (2001)
  4. "A Bone substitute", 21, pp.672~681 (1966)
  5. "The role of β-Tricalcium Phosphate in vasculized periosteum", 5, pp.275~282 (2000)
  6. "Piezoelectricity of living bone", 53, pp.325~ (1953), J Kyoto Pref Univ Med
  7. "Mechanical and electrical callus", 238, pp.457~ (1974)
  8. "A brief historical note on the use of electricity in the treatment of fracture", 161, pp.4~7 (1981)
  9. "Electrical and piezoelectrical properties of dental hard tissue", 212, pp.1565~1566 (1966)
  10. "Stress generated electrical potentials in the mandible and teeth", 12, pp.917~920 (1967)
  11. "Implication of bioelectric growth control in orthodontics and dentistry", 45, pp.34~42 (1975)
  12. "Non-invasive treatment of alveolar wounds In Electrical properties of bone and cartilage", pp.341~346
  13. "The effect of electrical current on the healing of mandibular freezed dried bone allograft in dog", 43, pp.403~407 (1985)
  14. "Electrical stimulation of bone and its implications for endosseous dental implantation", 16, pp.20~27 (1990)
  15. "The effect of pulsating electromagnetic fields on condylar growth in guinea pigs", 87, pp.211~223 (1985)
  16. "The biodegradation mechanism of calcium phosphate biomaterials in bone", 63, pp.408~412 (2002)
  17. "Bioactive ceramics:the effect of surface reactivity on bone formation and bone cell function", 20, pp.2287~2303 (1999)
  18. "Degradation characteristics of alpha and beta tri-calcium phosphate in minipigs", 63, pp.115~121 (2002)
  19. "Bioelectrical properties of bone and response of bone to electrical stimuli", 3, pp.109~141 (1991), CRC Press
  20. "Bioelectric pertubations of bone", 54, pp.73~87 (1984)
  21. "DNA sytheses in cartilage cell stimulated by oscillating eletrical field", 199, pp.690~ (1978)
  22. "Constant direct current treatment for established non-union of the tibia", 178, pp.179~ (1983)
  23. "Epiphyseal cartilage c-AMP changes produced by electrical and mechanical perturbations The development and application of pulsed electromagnetic fields", pp.59 61~68 88
  24. "A nonoperative salvage of surgically-resistant pseudoarthrosis and non-union by pulsating electromagnetic fields", 124, pp.128~143 (1977)
  25. "Pulsating electromagnetic current induction of mandibular condyles in the cat", pp.63~335
  26. "Pulsed electromagnetic fields promote bone formation around dental implants inserted into the femur of rabbits", 11, pp.354~360 (2000)
  27. "The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone a morphologic and microstructural in vivo study", 20, pp.756~763 (2002)
  28. "Effects of electromagnetic field on bone healing around commercially pure titanium surface:histologic mechanical study in rabbits", 12, pp.182~187 (2003)
  29. "Biological effects of electric and magnetic fields associated with ELF communications systems Proceeding of IEEE 1980", pp.98~104
  30. "Regulation of fracture repair by growth factors", 200, pp.165~170 (1992)
  31. "BMP signaling components are expressed in human fracture callus", 33, pp.362~371 (2003)
  32. "Titanium implants and BMP-7 in bone:an experimental model in the rabbit", 14, pp.247~254 (2003)
  33. "immunohistochemical localization in repair of a punch hole in the rabbit’s ear", 99, pp.1382~1389 (1997)
  34. "The experimental study of the regeneration on β-TCP in rabbit cranial bone", 30, pp.282~291 (2004)
  35. "Autogenous bone grafts in the rabbit maxillary sinus", 88, pp.26~32 (1999)
  36. "Vascular endotherial growth factor stimulates bone repair by promoting angiogenesis and bone turnover", 99, pp.9656~9661 (2002)

이 간행물의 다른 논문 (12건)

구순열비변형 환자에서 비교정술에 대한 비교 연구유선열pp. 287-294비관형 천연 셀룰로오스막 도관을 이용한 말초신경 재생에 대한 실험적 연구김성민, 이석근, 이종호pp. 295-307안면신경 압박손상 후 Adenovirus 매개 BDNF 유전자 전달을 통한 신경손상 회복에 관한 연구양병은, 이종호pp. 308-316성견의 골신장술에서 골절단술시 재조합 인간 골형성 단백질-7적용에 따른 가골반응과Osteocalcin 발현도에 대한 연구변준호, 김욱규, 성일용, 박봉욱, 조영철, 신상훈, 김종렬pp. 317-326지방기질유래 줄기세포의 골 분화 시 성장인자의 효과최연식, 김욱규, 정진섭pp. 327-333
원문 보기