구강 편평 상피 암종에서 TGF-β1과 MMP-2의 발현과 경부 임파절 전이 간의 상관 관계에 관한 연구
The clinical significance of the expression of TGF-β1 and MMP-2 related to the regional lymph node metastasis in the oral squamous cell carcinoma
2
조회
0
다운로드
1
인용
0
참고문헌
초록
Abstract
Several matrix metalloproteinases (MMPs) have been shown to play an important role in the invasion and metastasis of oral squamous cell carcinoma (OSCC). The members of the TGF-βsignaling pathway are being considered as predictive biomarkers for progressive tumorigenesis and molecular targets for the prevention and the treatment of cancer and metastasis. The aim of the present study was to find the clinical significance of the expression of TGF-β1 and MMP-2 related to the regional lymph node metastasis in OSCC. This study included 76 cases of primary OSCC, of which 42 cases showed regional lymph node metastases. Immunohistochemistry was used for the localization of protein. The relation between the expression of each protein and clinical variables was statistically evaluated. In results, the expression of TGF-β1 both main mass with lymph node metastasis and without lymph node metastasis was found not to be statistically significant (p>0.05). The expression of MMP-2 was found to be statistically significant related to regional lymph node metastasis (p<0.05). When compared the expression in the metastatic lymph node, TGF-β1 was significantly highly expressed than MMP-2 (p<0.05). In conclusion, the expression of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to the patients without lymph node metastasis, which could be useful in predicting the risk of lymph node metastasis in OSCC.
참고문헌 (20)
- "Matrix metalloproteinases and TGF- beta1 modulate oral tumor cell matrix", 316, pp.937~942 (2004)
- "Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 1988", Laara E
- "Metalloproteinases and their inhibitors: influence on tumor invasiveness and metastasis formation in head and neck", 28, pp.31~39 (2006)
- "Tissue level of matrix maetalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma", 74, pp.413~417 (1996)
- "Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential", 36, pp.207~213 (2000)
- "Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions", 16, pp.1911~1917 (2006)
- "Effects of dexamethasone and cell proliferation on the expression of matrix metalloproteinases in human mucosal normal and malignant cells", 75, pp.919~926 (1996)
- "Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma", 95, pp.44~50 (2001)
- "Evaluation of TGFbeta1 expressed by oral and maxillofacial malignant neoplasm", 11, pp.233~236 (2002)
- "Tumor metastasis in an orthotopic murine model of head and neck cancer:possible role of TGF-beta1 secreated by the tumor cells", 1, pp.1036~1051 (2006)
- "Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma", 193, pp.458~467 (2001)
- "Secretion of matrixmetalloprotinase-2 (72 kDa gelatinase", type IV collagenase = gelatinase A) by malignant human glioma cell lines: implications for the growth and cellular invasion of the extracellular matrix, 1996, pp.28, 13~24
- "Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts", 55, pp.963~967 (1995)
- "Activation of MMP-2 and MMP-9 in patients with oral squamous cell carcinoma", 90, pp.81~88 (2005)
- "Activation of matrixmetalloproteinase-2 in head and neck squamous cell carcinoma:Studies of clinical sample and in vitro cell lines co-cultured with fibroblasts", 150, pp.15~21 (2000)
- "Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors(TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamouscell carcinoma and lymph node metastasis", 77, pp.2239~1 2245 (1998)
- "The correlation between neck lymph node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cellcarcinomas", 22, pp.106~108 (2004)
- "Expressions of Matrix Metalloproteinases in Early-Stage Oral Squamous Cell Carcinoma as Predictive Indicators for Tumor Metastases and Prognosis", 10, pp.634~640 (2004)
- "Matrix metalloproteinases 2 and 9 in oral squamous cell carcinomas: manifestation and localization of their activity", 131, pp.340~346 (2005)
- "Expresion of transforming growth factor beta (TGF-beta) subtypes in oral squamous cell carcinoma", 19, pp.377~379 (2001)
