화학 발광 검사법을 이용한 구강 편평 태선의 진단
Chemiluminescence in diagnosis of oral lichen planus
1
조회
0
다운로드
0
인용
0
참고문헌
초록
Abstract
Purpose: This study was conducted in order to evaluate how chemiluminescent lighting (ViziLite.) could increase the sharpness of margin and contrast to normal mucosa in the diagnosis of oral lichen planus (OLP), the most frequent oral premalignant lesion, compared with direct visual inspection under incandescent light. Methods: 41 consecutive patients, diagnosed to have OLP with visual inspection under incandescent light, were further examined with chemiluminescent light. The degrees of margin sharpness and lesion contrast were ranked on a scale from 1 to 3 for all patients under visual inspection and chemiluminescent light. The presence of additional lesion only detected by chemiluminescent light, complication, and discomfort were checked for each patient. After both screening tests, biopsy specimens were harvested from all patients with scalpels and histopathologic assessments were done. Results: All 41 patients were diagnosed to have OLP by both visual inspection and chemiluminescent light examination. This result was definitively diagnosed by histopathology. Degrees of margin sharpness and lesion contrast were increased by chemiluminescent light compared with visual inspection, but only the difference of lesion contrast was statistically significant. In 22.0% of patients, additional lesions were detected and 88.9% of them were diagnosed to have OLP histopathologically. 17.1% of patients noted discomfort and 9.8% of patients showed complications after chemiluminescent test. Conclusion: Chemiluminescent light may not be proper for the screen test of oral cancer or premalignant lesion but showed some possibility for additional diagnostic tool for definitively diagnosed patients in determination of lesion margin and scope.
참고문헌 (33)
- "Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations", 43, pp.60~66 (2006)
- Myoung H, "Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: a clinical and histopathological analysis of 113 patients", 35, pp.1005~1010 (2006)
- "Current surgical diagnosis and treatment" (2003), New York: Lange Medical Books[DOI]
- Schliephake H, "Prognostic relevance of molecular markers of oral cancer--a review", 32, pp.233~245 (2003)
- "Independent prognostic factors of 861 cases of oral squamous cell carcinoma in Korean adults", 42, pp.208~217 (2006)
- "US Department of Health and Human Services National Institutes of Health" (1973)
- Tagg R, "Biophotonic and other physical methods for characterizing oral mucosa", 38, pp.215~240 (2005)
- "Cytological screening for early mouth cancer. Cancer 1962", pp.1119~24
- Brunotto M, "of exfoliative cytology as prediction factor in oral mucosa lesions", 10, pp.E92~E102 (2005)
- "Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome", 65, pp.8017~8021 (2005)
- Sciubba JJ, "Improving detection of precancerous and cancerous oral lesions. Computer-assisted analysis of the oral brush biopsy. U.S. Collaborative OralCDx Study Group", 130, pp.1445~1457 (1999)
- "ViziLite"
- "The efficacy of oral lumenoscopy (ViziLite) in visualizing oral mucosal lesions", 26, pp.171~174 (2006)
- Farah CS, "A pilot case control study on the efficacy of acetic acid wash and chemiluminescent illumination (ViziLitetrade mark) in the visualisation of oral mucosal white lesions" (2006)
- Kerr AR, "Clinical evaluation of chemiluminescent lighting: an adjunct for oral mucosal examinations", 17, pp.59~63 (2006)
- "Efficacy of the ViziLite system in the identification of oral lesions", 65, pp.424~426 (2007)
- "Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions", 34, pp.521~527 (2005)
- Huber MA, "Acetic acid wash and chemiluminescent illumination as an adjunct to conventional oral soft tissue examination for the detection of dysplasia: a pilot study", 35, pp.378~384 (2004)
- "Prevalence of oral mucosal lesions in a representative population", 38, pp.23~29 (2007)
- "“How to use ViziLite. Plus with Tblue630”from ViziLite"
- "Seeing the light: using chemiluminescence to demonstrate chemical fundamentals", 14, pp.51~53 (2000)
- Parham GP, "Comparison of cell collection and direct visualization cervical cancer screening adjuncts", 188, pp.S13~S20 (2003)
- Edwards G, "Comparison of chemiluminescent light versus incandescent light in the visualization of acetowhite epithelium. Am J Gynecolol Health 1992", pp.6~11
- Lonky NM, "Ability of visual tests to predict underlying cervical neoplasia. Colposcopy and speculoscopy", 40, pp.530~536 (1995)
- Yu BK, "Improved early detection of cervical intraepithelial lesions by combination of conventional Pap smear and speculoscopy", 24, pp.495~499 (2003)
- "Acetowhite epithelium", 95, pp.691~694 (2004)
- "Lichenoid dysplasia: a distinct histopathologic entity", liche(id dysplasia), pp.308~15, a distinct histopathologic entity. Oral Surg Oral Med Oral Pathol 1985
- "A prospective study of findings and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol 1991", pp.665~70
- "High proliferative activity and chromosomal instability in oral lichen planus", 35, pp.1140~1144 (2006)
- "Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in icelanD", 110, pp.192~198 (2002)
- "Molecular genetics of premalignant oral lesions", 13, pp.126~133 (2007)
- , 1997, 294~306
- , 1997, 294~306