측두하악관절 장애 환자에서 관절원판후조직의 에스트로겐 수용체(ER)의 단백 발현
EXPRESSION OF ESTROGEN RECEPTORS IN RETRODISCAL TISSUE OF THE TEMPOROMANDIBULAR JOINT DISORDER PATIENTS
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Those composing temporomandibular joint (TMJ) complex such as the temporal bone, the disc and the mandibular condyle perform their own functions with organic relation. The retrodiscal tissue is the main area of pain induction and contributes to compositional change of synovial fluid. If displacement of the disc lasts long time, not only adaptive changes, but also destructive or degenerative changes may happen. It was reported that these changes and symptoms appear mostly to female rather than male and especially, in the case of patients suffering from TMJ disorder, a large quantity of female sex hormone is found in the joint synovium. And that may play a role in bone resorption and inflammation. Also, the frequency and the intensity of pain perception for female is reported to be much more than for male. In this study, we investigated the expression extents of estrogen receptors (ER) and progesteron receptors (PR) in retrodiscal tissue with immunohistochemistry among the patients received TMJ surgery and compared with MRI findings and surgical findings. We report the relations between the expression of ER in retrodiscal tissue and the pathological change in TMJ, such as inflammation, internal derangement and osteoarthritis.
Abstract
Those composing temporomandibular joint (TMJ) complex such as the temporal bone, the disc and the mandibular condyle perform their own functions with organic relation. The retrodiscal tissue is the main area of pain induction and contributes to compositional change of synovial fluid. If displacement of the disc lasts long time, not only adaptive changes, but also destructive or degenerative changes may happen. It was reported that these changes and symptoms appear mostly to female rather than male and especially, in the case of patients suffering from TMJ disorder, a large quantity of female sex hormone is found in the joint synovium. And that may play a role in bone resorption and inflammation. Also, the frequency and the intensity of pain perception for female is reported to be much more than for male. In this study, we investigated the expression extents of estrogen receptors (ER) and progesteron receptors (PR) in retrodiscal tissue with immunohistochemistry among the patients received TMJ surgery and compared with MRI findings and surgical findings. We report the relations between the expression of ER in retrodiscal tissue and the pathological change in TMJ, such as inflammation, internal derangement and osteoarthritis.
참고문헌 (29)
- LeResche L, "Epidermiology of temporomandibular disorders: Implications for the investigation of etiologic factors", Crit Rev Oral Biol Med, 8, pp.291~305 (1997)
- Kullila M, "TMD treatment need in relation to age, gender, stress, and diagnostic subgroup", J Orofac Pain, 12, pp.67~74 (1998)
- Meisler JG, "Chronic pain conditions in women", J Womens Health, 8, pp.313~320 (1999)
- Landi N, "Sexual hormone serum levels and temporomandibular disorders: A preliminary study", Gynecol Endocrinol, 20, pp.99~103 (2005)
- Abubaker AO, "Estrogen and progesterone receptors in temporomandibular joint discs of symptomatic and asymptomatic persons: A preliminary study", J Oral Maxillofac Surg, 51, pp.1096~1100 (1993)
- Ko JY, "Magnetic resonance evidence of joint effusion in patients with temporomandibular joint disorders", Korean J Oral Maxillofac Radiol, 31, pp.73~84 (2001)
- 허종기, "측두하악 관절원판 후조직의 MMP(matrix metalloproteninase)-1과 MMP-2 Mrna의 발현", 대한구강악안면외과학회지, 29(4), pp.212~218 (2003), 대한구강악안면외과학회
- Huh JK, "Relationship between histologic features of the retrodiskal tissues and magnetic resonance imaging findings in temporomandibular joint internal derangement", J Kor Oral Maxillofac Surg, 25, pp.378~382 (2000)
- Dworkin SF, "Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique", J Craniomandib Disord, 6, pp.301~355 (1992)
- Stegenga B, "Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement", J Orofac Pain, 15, pp.193~205 (2001)
- Stegenga B, "Osteoarthritis as the cause of craniomandibular pain and dysfunction: A unifying concept", J Oral Maxillofac Surg, 47, pp.249~256 (1989)
- Stegenga B, "Tissue responses to degenerative changes in the temporomandibular joint", A review J Oral Maxillofac Surg, 49, pp.1079~1088 (1991)
- LeResche L, "Use of exogenous hormones and risk of temporomandibular disorder pain", Pain, 69, pp.153~160 (1997)
- Kapila S, "Targeted induction of collagenase and stromelysin by relaxin in unprimed and beta-estradiol-primed diarthrodial joint fibrocartilaginous cells but not on synoviocytes", Lab Invest, 78, pp.925~938 (1998)
- Arnett GW, "Progressive mandibular retrusion-idiopathic condylar resorption", Part I Am J Orthod Dentofacial Orthop, 10, pp.8~15 (1996)
- McGuire WL, "Current status of estrogen and progesterone receptors in breast cancer", Cancer, 32, pp.2934~2947 (1977)
- Kaplan PA, "Current status of temporomandibular joint imaging for the diagnosis of internal derangements", AJR Am J Roentgenol, 152, pp.697~705 (1989)
- Stegenga B, "Osteoarthritis of the temporomandibular joint organ and its relationship to disc displacement", J Orofac Pain, 15, pp.193~205 (2001)
- Isberg A, "Tissue reactions associated with internal derangement of the temporomandibular joint: A radiographic, crymorphologic, and histologic study", Acta Odontol Scand, 44, pp.159~164 (1986)
- Corvol M, "Bone and cartilage responsiveness to sex steroid hormones", J Steroid Biochem Mol Biol, 43, pp.415~418 (1992)
- Gage JP, "Collagen biosynthesis related to temporomandibular joint clicking in childhood", J Prosthet Dent, 53, pp.714~717 (1985)
- Milam SB, "Sexual dimorphism in the distribution of estrogen receptors in the temporomandibular joint complex of the baboon", Oral Surg Oral Med Pathol, 64, pp.527~532 (1987)
- Wilkinson TM, "A histologic study of retrodiscal tissues of the human temporomandibular joint in the open and closed position", J Orofac Pain, 8, pp.7~17 (1994)
- Nitzan DW, "Intra-articular pressure measurements in patients with suddenly developing, severely limited mouth opening", J Oral Maxillofac Surg, 50, pp.1038~1043 (1992)
- Romanelli GG, "Evaluation of temporomandibular joint internal derangement", J Orofac Pain, 7, pp.254~262 (1993)
- Kubota T, "Identification of matrix metalloproteinases (MMPs) in synovial fluid from patients with temporomandibular disorder", Eur J Oral Sci, 106, pp.992~998 (1998)
- Ratcliffe A, "Proteoglycans in the synovial fluid of the temporomandibular joint as an indicator of changes in cartilage metabolism during primary and secondary osteoarthritis", J Oral Maxillofac Surg, 56, pp.204~208 (1998)
- Takahashi T, "Relationship between joint effusion, joint pain, and protein levels in joint lavage fluid of patients with internal derangement and osteoarthritis of the temporomandibular joint", J Oral Maxillofac Surg, 57, pp.1187~1193 (1999)
- Flake NM, "Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint", Am J Physiol Regul Integr Comp Physiol, 291, pp.343~348 (2006)