Undifferentiated pleomorphic sarcoma of the mandible
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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindle-cell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferenti-ated neoplasms.
Abstract
Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindle-cell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferenti-ated neoplasms.
참고문헌 (34)
- Ozzello L, "Cultural characteristics of malignant histiocytomas and fibrous xanthomas", Cancer, 16, pp.331~344 (1963)[DOI]
- O’Brien JE, "Malignant fibrous xanthomas", Cancer, 17, pp.1445~1458 (1964)[DOI]
- Chang RC, "Undifferentiated pleomorphic sarcoma of the parotid gland : a rare pediatric case", Head Neck, 30, pp.970~973 (2008)[DOI]
- Fleury RN, "Malignant fibrous histiocytoma(undifferentiated high-grade pleomorphic sarcoma)occurring in tuberous sclerosis : a case report", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103, pp.e54~9 (2007)[DOI]
- Alfredo E, "Oral undifferentiated highgrade pleomorphic sarcoma: report of a case", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 105, pp.e37~e40 (2008)[DOI]
- Abdul-Karim FW, "Malignant fibrous histiocytoma of jaws. A clinicopathologic study of 11 cases", Cancer, 56, pp.1590~1596 (1985)[DOI]
- Kyung-Ran Park, "Myofibroblastic sarcoma of the mandible: a case report", 대한구강악안면외과학회지, 38(4), pp.240~244 (2012), 대한구강악안면외과학회[DOI]
- 박지훈, "하악에 발생한 저등급의 점액섬유육종: 증례보고", 대한구강악안면외과학회지, 37(1), pp.67~71 (2011), 대한구강악안면외과학회
- 권귀영, "Sarcomatoid carcinoma of the mandible: report of a case", 대한구강악안면외과학회지, 36(3), pp.228~230 (2010), 대한구강악안면외과학회
- Kim HW, "Surgical treatment of the osteogenic sarcoma in mandible : report of two cases", J Korean Assoc Oral Maxillofac Surg, 13, pp.11~18 (1987)
- Kim JW, "A case report of Ewing’s sarcoma of the mandible", J Korean Assoc Oral Maxillofac Surg, 14, pp.22~26 (1988)
- Kim CS, "Osteosarcoma around the resin implant in the area of the mandible-a case report-", J Korean Assoc Oral Maxillofac Surg, 22, pp.222~229 (1996)
- 김일규, "Odontogenic carcinosarcoma of the mandible: a case report and review", 대한구강악안면외과학회지, 41(3), pp.139~144 (2015), 대한구강악안면외과학회
- Hardison SA, "Malignant fibrous histiocytoma of the head and neck : a case series", Am J Otolaryngol, 34, pp.10~15 (2013)[DOI]
- Koyama T, "Radiation-induced undifferentiated high-grade pleomorphic sarcoma(malignant fibrous histiocytoma)of the mandible : report of a case arising in the background of long-standing osteomyelitis with a review of the literature", Pathol Res Pract, 210, pp.1123~1129 (2014)[DOI]
- Thompson LD, "Pleomorphic sarcoma of the neck", Ear Nose Throat J, 94, pp.376~377 (2015)[DOI]
- Thiagarajan A, "Radiation-induced sarcomas of the head and neck", World J Clin Oncol, 5, pp.973~981 (2014)[DOI]
- Tanaka T, "Transformation of benign fibrous histiocytoma into malignant fibrous histiocytoma in the mandible:case report", J Oral Maxillofac Surg, 69, pp.e285~e290 (2011)[DOI]
- O’Neill JP, "Head and neck sarcomas : epidemiology, pathology, and management", Neurosurg Clin N Am, 24, pp.67~78 (2013)[DOI]
- Park SW, "Malignant fibrous histiocytoma of the head and neck : CT and MR imaging findings", AJNR Am J Neuroradiol, 30, pp.71~76 (2009)[DOI]
- Li J, "Computed tomography and magnetic resonance imaging findings of malignant fibrous histiocytoma of the head and neck", Mol Clin Oncol, 4, pp.888~892 (2016)[DOI]
- Fletcher CDM, "Pathology and genetics of tumours of soft tissue and bone" (2002), IARC Press
- Weiss SW, "Enzinger and Weiss’s soft tissue tumors", pp.535~569 (2001), Mosby
- Chul-Hwan Kim, "Undifferentiated Pleomorphic Sarcoma in Mandible", Maxillofacial Plastic Reconstructive Surgery, 36(6), pp.303~307 (2014), 대한악안면성형재건외과학회[DOI]
- Senel FC, "Malignant fibrous histiocytoma of the mandible", Dentomaxillofac Radiol, 35, pp.125~128 (2006)[DOI]
- Thomas ME, "Electron microscopy in the diagnosis of malignant fibrous histiocytoma of the lung presenting as metastasis to the maxillary gingiva", Int J Oral Maxillofac Surg, 42, pp.99~101 (2013)[DOI]
- Satomi T, "Radiation-induced malignant fibrous histiocytoma of the maxilla", Odontology, 99, pp.203~208 (2011)[DOI]
- Lin SK, "Oral post-radiation malignant fibrous histiocytoma : a clinicopathological study", J Oral Pathol Med, 23, pp.324~329 (1994)[DOI]
- Lambade PN, "Malignant fibrous histiocytoma : an uncommon sarcoma with pathological fracture of mandible", J Maxillofac Oral Surg, 14(Suppl 1), pp.283~287 (2015)[DOI]
- Barnes L, "Malignant fibrous histiocytoma of the head and neck. A report of 12 cases", Arch Otolaryngol Head Neck Surg, 114, pp.1149~1156 (1988)[DOI]
- Kasat VO, "Malignant fibrous histiocytoma of maxillary alveolar ridge extending to the hard palate", J Cancer Res Ther, 10, pp.422~424 (2014)[DOI]
- Suzuki S, "A case of cutaneous malignant fibrous histiocytoma with multiple organ metastases", Kaohsiung J Med Sci, 29, pp.111~115 (2013)[DOI]
- Agnihotri R, "A rare case of malignant fibrous histiocytoma of the gingiva", J Periodontol, 79, pp.955~960 (2008)[DOI]
- Sato T, "Radiographic evaluation of malignant fibrous histiocytoma affecting maxillary alveolar bone : a report of 2 cases", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 92, pp.116~123 (2001)[DOI]