본문 바로가기
KERD
논문KCI 등재

구강 편평세포암종의 경부 림프절 전이에 대한 임상통계학적 연구

A CLINICO-STATISTICAL STUDY ON CERVICAL LYMPH NODE METASTASIS OF ORAL SQUAMOUS CELL CARCINOMA

김진수|김진욱|이재욱
대한구강악안면외과학회 (Korean Association Of Oral And Maxillofacial Surgeons)|2008.12|대한구강악안면외과학회지 (Journal of the Korean Association of Oral and Maxillofacial Surgeons)|제34권 제6호|pp. 594-601

2

조회

0

다운로드

2

인용

0

참고문헌

주제분류치의학

초록

Cervical lymph node metastasis is one of the most important predicting factors that influence the prognosis of oral squamous cell carcinoma. Correct diagnosis on cervical lymph node metastasis is essential in determining the extent of operation and treatment modality. So we investigated a clinico-statistical evaluation on cervical lymph node metastasis in 183 patients who were diagnosed with oral squamous cell carcinoma at the Department of Oral and Maxillofacial Surgery in Kyungpook National University Hospital, from January 1st, 1999 to December 31st, 2007. The following results were obtained : 1. Among 183 patients who were diagnosed with oral squamous cell carcinoma, 149 were male and 49 were female. The average age of the patients was 61.8 years old. 2. Patients with advanced T classification showed higher incidence of cervical lymph node metastasis than those with lower T classification. 3. Patients with less differentiated tumors had higher tendency of manifesting cervical lymph node metastasis than those with more differentiated tumors. 4. Sensitivity and specificity on PET/CT was 87.5% and 58.3% respectively. PET/CT showed higher sensitivity and lower false-negative values than those of CT or USG. 5. The 5 - year survival rate of all the oral squamous cell carcinoma patients appeared to be 63.2% By N classification, patients in N0 stage showed a higher survival rate than patients in N1 or N2. 5 - year survival rates according to the modality of neck dissection were as follows in increasing order: no neck dissection group, MRND group, SND group, and RND group.

Abstract

Cervical lymph node metastasis is one of the most important predicting factors that influence the prognosis of oral squamous cell carcinoma. Correct diagnosis on cervical lymph node metastasis is essential in determining the extent of operation and treatment modality. So we investigated a clinico-statistical evaluation on cervical lymph node metastasis in 183 patients who were diagnosed with oral squamous cell carcinoma at the Department of Oral and Maxillofacial Surgery in Kyungpook National University Hospital, from January 1st, 1999 to December 31st, 2007. The following results were obtained : 1. Among 183 patients who were diagnosed with oral squamous cell carcinoma, 149 were male and 49 were female. The average age of the patients was 61.8 years old. 2. Patients with advanced T classification showed higher incidence of cervical lymph node metastasis than those with lower T classification. 3. Patients with less differentiated tumors had higher tendency of manifesting cervical lymph node metastasis than those with more differentiated tumors. 4. Sensitivity and specificity on PET/CT was 87.5% and 58.3% respectively. PET/CT showed higher sensitivity and lower false-negative values than those of CT or USG. 5. The 5 - year survival rate of all the oral squamous cell carcinoma patients appeared to be 63.2% By N classification, patients in N0 stage showed a higher survival rate than patients in N1 or N2. 5 - year survival rates according to the modality of neck dissection were as follows in increasing order: no neck dissection group, MRND group, SND group, and RND group.

참고문헌 (42)

  1. Parkin DM, "Global Cancer Statistics, 2002", CA Cancer J Clin, 55, pp.74~108 (2005)
  2. Shiboski CH, "Trends in oral cancer rates in the United States, 1973-1996", Community Dent Oral Epidemiol, 28, pp.249~256 (2000)
  3. "사 망 원 인 (103항 목 )/성 /시 도 별 사 망 자 수"[URL]
  4. Cho KJ, "Statistics on head and neck cancers in Korea", International Congress Series, 1240, pp.1015~1018 (2003)
  5. McGurk M, "Delay in diagnosis and its effect on outcome in head and neck cancer", Br J Oral Maxillofac Surg, 43, pp.281~284 (2005)
  6. 정인교, "구강 편평상 피세포암의 처치와 예후에 관한 임상적 연구", 대한구강악안 면외과학회지, 22, pp.346~355 (1996)
  7. Rawashdeh MA, "Malignant oral tumors in Jordanians, 1991-2001. A descriptive epidemiological study", Int J Oral Maxillofac Surg, 33, pp.183~188 (2004)
  8. Leite ICG, "Survival analysis in a sample of oral cancer patients at a reference hospital in Rio de Janeiro, Brazil", Oral Oncol, 34, pp.347~352 (1998)
  10. 조용석, "한국인 구강편평상피세포암에 관한 임상적 연구", 대한구강악안면외과학회지, 18, pp.40~52 (1992)
  11. 김성진, "구강암의 진단에 사용되어지는 PET", CT: 임상 증례, 2005, pp.31(2), 178~182[DOI]
  12. 이재준, "구강암 경부임파절 전이에 대한 술전 평가의 정확성", 대한구강악안면외과학회지, 32(2), pp.151~156 (2006), 대한구강악안면외과학회
  13. Braams JW, "nodal spread of squamous cell carcinoma of the oral cavity detected with PET-tyrosine, MRI and CT", J Nucl Med, 37, pp.897~901 (1996)
  14. Kim MR, "Utility of 18F -fluorodeoxyglucose positron emission tomography in the preoperative staging of squamous cell carcinoma of the oropharynx", Eur J Surg Oncol, 33, pp.633~638 (2007)
  15. -Fluorodeoxy -glucose를 이용한 양전자방출 단층촬영의 임상적 연구, "대한구강악안면외과학회지", 2000, 462~469
  16. Goshen E, "PET", CT in the eval -uation of patients with squamous cell cancer of the head and neck, 2006, pp.35, 332~336
  17. Greene FL, "AJCC Cancer staging manual, sixth edition" (2002), New York, Springer-Verlag
  18. Febrile A, "Classification and terminology of neck dissection", Arch Otolaryngol Head Neck Surg, 128, pp.747~748 (2002)
  19. Robbins KT, "Neck dissection classification update", Arch Otolaryngol Head Neck Surg, 128, pp.751~758 (2002)
  20. 김경욱, "구강내 부위별 편평 상피암종의 생존율에 관한 임상 연구", 대한구강악안면외과학회지, 29(5), pp.315~322 (2003), 대한구강악안면외과학회
  21. Lo WL, "Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy : Factors affecting survival", J Oral Maxillofac Surg, 61, pp.751~758 (2003)
  22. 조준현, "구강암 환자에 대한 임상통계학적 분석", 대한악안면성형재건외과학회지, 20, pp.33~44 (1998)
  23. Shear M, "The prediction of lymph node metastases from oral squamous carcinoma", Cancer, 37(4), pp.1901~1907 (1976)
  24. 이동수, "구강암의 경부임파절 전이에 대한 임상적연구", 대한구강악안면외과학회지, 25, pp.141~150 (1999)
  25. Woolgar JA, "Correlation of histopathologic findings with clinical and radiologic assessments of cervical lymph-node metastases in oral cancer", Int J Oral Maxillofac Surg, 24, pp.30~37 (1995)
  26. 김명진, "구강암, 1판", pp.98~163 (2002), 지성출판사
  27. Barzilai G, "Pattern of regional metastases from cutaneous squamous cell carcinoma of the head and neck", Otolaryngol Head Neck Surg, 132, pp.852~856 (2006)
  28. Layland MK, "The influence of lymph node metastases in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+", Laryngoscope, 115, pp.629~639 (2005)
  29. 김정호, "원저 : 두경부암 경부 림프절 전이의 진단에서 (18)F-FDG-PET", CT의 유용성, 2005, pp.39(5), 269~277[DOI]
  30. 김인주, "두경부암에서의 PET-CT의 유용성", 임상이비학회지, 16, pp.175~179 (2005)
  31. Murakami R, "Impact of FDG-PET", CT imaging on nodal staging for head and neck squamous cell carcinoma, 2007, pp.68, 377~382
  32. FDG-PET for surveillance of oral squamous cell carcinoma after surgical salvage therapy, "Oral Oncol", 2006, 297~305
  33. Wong WL, "The Impact of FDG PET on the management of occult primary head and neck tumors", Clin Oncol, 15, pp.461~466 (2003)
  34. Scully C, "Recent advances in Oral Oncology 2007: Imaging, treatment and treatment outcomes", Oral Oncol, 44, pp.211~215 (2008)
  35. 김용각, "구강악안면 암환자의 초진시와 추적검사시 양전자 방출 단층촬영의 임상적 유용성", 대한구강악안면외과학회지, 25, pp.256~260 (1999)
  36. Goerres GW, "Impact of whole body positron emission tomography on initial staging and therapy in patients with squamous cell carcinoma of the oral cavity", Oral Oncol, 39, pp.547~551 (2003)
  37. Santa MPL, "Neck dissection for squamous cell carcinoma of the head and neck", Otolaryngol Head Neck Surg, 136, pp.S41~S45 (2007)
  38. O-charoenrat P, "Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer", Oral Oncol, 39, pp.386~390 (2003)
  39. Sparano A, "Multivariate predictors of occult neck metastasis in early oral tongue cancer", Otolaryngol Head Neck Surg, 131, pp.472~476 (2004)
  40. 조병호, "구강암의 치료 후 생존율에 영향을 주는 인자에 대한 후향적 연구", 대한악안면성형재건외과학회지, 24(3), pp.211~217 (2002), 대한악안면성형재건외과학회
  41. Kligerman J, "Supraomohyoid neck dissection in the treatment of T1", T2 squamous cell carcinoma of oral cavity, 1994, pp.168, 391~394
  42. 김규영, "구강저 편평세포암종의 예 후에 관한 임상적 연구", 대한구강악안면외과학회지, 19, pp.464~476 (1993)

관련 논문AI추천

구강암 환자에서 18F FDG-PET/CT의 경부 림프절 전이 평가 유용성유민기, 유선열대한구강악안면외과학회 · 대한구강악안면외과학회지2009 · 제35권 제4호구강설에 발생한 편평상피세포암의 특성과 치료효과남웅, 김기호, 김형준, 차인호, 최은주대한구강악안면외과학회 · 대한구강악안면외과학회지2011 · 제37권 제1호구강암 환자에서 보존적 경부청소술의 효과국민석, 김경락, 김방신, 박홍주, 양지웅, 오희균, 유선열, 정연욱, 허다니엘대한구강악안면외과학회 · 대한구강악안면외과학회지2010 · 제36권 제6호The impact factors on 5-year survival rate in patients operated with oral cancer금동호, 김용덕, 김욱규, 김효근, 노영채, 송재민, 신상훈, 윤상용, 이재열, 이정한, 정인교, 황대석대한구강악안면외과학회 · 대한구강악안면외과학회지2013 · 제39권 제5호한국인에서 구강 편평세포암종의 5년 생존율남웅, 강상훈, 김형준, 류재인, 오민석, 조정림, 차인호대한구강악안면외과학회 · 대한구강악안면외과학회지2009 · 제35권 제2호조기 구강설 편평상피암종에서 경부 림프절 전이 인자 분석김민식, 박영학, 선동일, 조광재, 조정해, 주영훈대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2009 · 제52권 제1호

이 간행물의 다른 논문 (12건)

미니돼지에서 다능성 피부유래 전구세포의 추출과 이의 다배엽 세포로의 분화유도에 대한 연구최문정, 김욱규, 박봉욱, 노규진, 강은주, 김종렬, 변준호pp. 588-593Acrylamide가 인체상피세포의 발암화에 미치는 영향김진욱, 김상규, 김진수pp. 602-610구강내 악성흑색종에 대한 임상연구김욱규, 신상훈, 김용덕, 정인교, 허진호, 김종렬, 황대석pp. 611-615삼차원 전산화 단층촬영술을 이용한 안모 비대칭환자의 골격 분석최정구, 오세리, 오승환, 민승기, 최문기, 이준, 유대현, 권경환pp. 622-627다양한 소독방법이 PPDO-hybrid-PLGA nanofiber scaffold의 형태와 세포부착에 미치는 영향에 관한 연구민현기, 이주현, 정주영, 강나라pp. 628-634
원문 보기