The impact factors on 5-year survival rate in patients operated with oral cancer
2
조회
0
다운로드
10
인용
0
참고문헌
키워드
초록
Objectives: The purpose of this study is to analyze clinical impact factors on the survival rate, and to acquire basic clinical data for the diagnosis of oral cancer, for a determination of the treatment plan with long-term survival in oral cancer patients. Materials and Methods: Through a retrospective review of the medical records, the factors for long-term survival rate were analyzed. Thirty-seven patients, among patient database with oral cancer treated in the Department of Oral and Maxillofacial Surgery at Pusan National University Hospital within a period from March 1998 to March 2008, were selected within the study criteria and were followed-up for more than 5 years. The analyzed factors were gender, age, drinking, smoking, primary tumor site, type of cancer, TNM stage, recurrence of affected region, and metastasis of cervical lymph node. The 5-year survival rate on the impact factors was calculated statistically using the Kaplan-Meier method. Results: By classification of clinical TNM at the 1st visit, there were 11 (29.7%) cases for stage I, 11 (29.7%) cases for stage II, 3 (8.1%) cases for stage III, and 12 (32.5%) cases for stage IV. The 5-year survival rate of total oral cancer patients after the operation were 75.7%, pathological TNM stage related 5-year survival rate were as follows: stage I 90.0%, stage II 81.8%, stage III 100% and stage IV 45.5%; in which the survival rate difference by each stage was significantly observed. The recurrence of cervical lymph node was the significant impact factor for the survival rate, because only 30.0% the survival rate in recurrent cases existed. During the follow-up, there were 15 (40.5%) patients with confirmed recurrence, and the 5-year survival rate of these patients was decreased as 46.7%. Conclusion: The classification of clinical and pathological TNM stage, local recurrence after surgery, and metastasis of cervical lymph node after surgery were analyzed as the 3 most significant factors.
Abstract
Objectives: The purpose of this study is to analyze clinical impact factors on the survival rate, and to acquire basic clinical data for the diagnosis of oral cancer, for a determination of the treatment plan with long-term survival in oral cancer patients. Materials and Methods: Through a retrospective review of the medical records, the factors for long-term survival rate were analyzed. Thirty-seven patients, among patient database with oral cancer treated in the Department of Oral and Maxillofacial Surgery at Pusan National University Hospital within a period from March 1998 to March 2008, were selected within the study criteria and were followed-up for more than 5 years. The analyzed factors were gender, age, drinking, smoking, primary tumor site, type of cancer, TNM stage, recurrence of affected region, and metastasis of cervical lymph node. The 5-year survival rate on the impact factors was calculated statistically using the Kaplan-Meier method. Results: By classification of clinical TNM at the 1st visit, there were 11 (29.7%) cases for stage I, 11 (29.7%) cases for stage II, 3 (8.1%) cases for stage III, and 12 (32.5%) cases for stage IV. The 5-year survival rate of total oral cancer patients after the operation were 75.7%, pathological TNM stage related 5-year survival rate were as follows: stage I 90.0%, stage II 81.8%, stage III 100% and stage IV 45.5%; in which the survival rate difference by each stage was significantly observed. The recurrence of cervical lymph node was the significant impact factor for the survival rate, because only 30.0% the survival rate in recurrent cases existed. During the follow-up, there were 15 (40.5%) patients with confirmed recurrence, and the 5-year survival rate of these patients was decreased as 46.7%. Conclusion: The classification of clinical and pathological TNM stage, local recurrence after surgery, and metastasis of cervical lymph node after surgery were analyzed as the 3 most significant factors.
참고문헌 (32)
- Kademani D, "Oral cancer", Mayo Clin Proc, 82, pp.878~887 (2007)
- Ju Rim Sun, "Oral cancer incidence based on annual cancer statistics in Korea", 대한구강악안면외과학회지, 38(1), pp.20~28 (2012), 대한구강악안면외과학회
- Woolgar JA, "Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection", Oral Oncol, 35, pp.257~265 (1999)
- Frierson HF Jr, "Prognostic factors in squamous cell carcinoma of the lower lip", Hum Pathol, 17, pp.346~354 (1986)
- Prieto I, "Prognostic factors for cancer of the oral cavity", Quintessence Int, 36, pp.711~717 (2005)
- Rodriguez T, "Risk factors for oral and pharyngeal cancer in young adults", Oral Oncol, 40, pp.207~213 (2004)
- Haigentz M Jr, "Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment", Oral Oncol, 48, pp.787~793 (2012)
- Funk GF, "Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report", Head Neck, 24, pp.165~180 (2002)
- 김명윤, "최근 8년간 구강암 환자에 대한 임상통계학적 연구", 대한구강악안면외과학회지, 33(6), pp.660~668 (2007), 대한구강악안면외과학회
- Napier SS, "Natural history of potentially malignant oral lesions and conditions: an overview of the literature", J Oral Pathol Med, 37, pp.1~10 (2008)
- Chen JK, "Intraoral squamous cell carcinoma. Epidemiologic patterns in Connecticut from 1935 to 1985", Cancer, 66, pp.1288~1296 (1990)
- Blot WJ, "Smoking and drinking in relation to oral and pharyngeal cancer", Cancer Res, 48, pp.3282~3287 (1988)
- Sandoval M, "The role of vegetable and fruit consumption and other habits on survival following the diagnosis of oral cancer: a prospective study in Spain", Int J Oral Maxillofac Surg, 38, pp.31~39 (2009)
- Kwon HK, "Risk factors for oral cancer; a case-control study", J Korean Oral Maxillofac Surg, 28, pp.395~400 (2002)
- Krolls SO, "Squamous cell carcinoma of the oral softtissues: a statistical analysis of 14,253 cases by age, sex, and race of patients", J Am Dent Assoc, 92, pp.571~574 (1976)
- Syrigos KN, "Head and neck cancer in the elderly: an overview on the treatment modalities", Cancer Treat Rev, 35, pp.237~245 (2009)
- Shah JP, "Head and neck surgery and oncology" (2003), Mosby
- Goshen E, "PET", CT in the evaluation of patients with squamous cell cancer of the head and neck, 2006, pp.35, 332~336
- Nahmias C, "Positron emission tomography", computerized tomography (PET, head and neck cancer, pp.J Oral Maxillofac Surg, 2007[DOI]
- CT scanner, "Recent studies with a combined PET", pp.1999, Townsend DW
- Ferlito A, "Micrometastases: have they an impact on prognosis?", Ann Otol Rhinol Laryngol, 108, pp.1185~1189 (1999)
- Cho JH, "Clinical and statistical analysis of the oral cancer patients: a statistical analysis of 256 cases", J Korean Assoc Maxillofac Plast Reconstr Surg, 20, pp.33~44 (1998)
- 이재욱, "구강 편평세포암종의 경부 림프절 전이에 대한 임상통계학적 연구", 대한구강악안면외과학회지, 34(6), pp.594~601 (2008), 대한구강악안면외과학회
- 오민석, "한국인에서 구강 편평세포암종의 5년 생존율", 대한구강악안면외과학회지, 35(2), pp.83~88 (2009), 대한구강악안면외과학회
- Koo BS, "Management of contralateral N0 neck in oral cavity squamous cell carcinoma", Head Neck, 28, pp.896~901 (2006)
- Zbären P, "Elective neck dissection for carcinomas of the oral cavity: occult metastases, neck recurrences, and adjuvant treatment of pathologically positive necks", Am J Surg, 191, pp.756~760 (2006)
- O'Brien CJ, "The use of clinical criteria alone in the management of the clinically negative neck among patients with squamous cell carcinoma of the oral cavity and oropharynx", Arch Otolaryngol Head Neck Surg, 126, pp.360~365 (2000)
- Keski-Säntti H, "Elective neck treatment versus observation in patients with T1", T2 N0 squamous cell carcinoma of oral tongue, 2006, pp.42, 96~101
- Lindberg R, "Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts", Cancer, 29, pp.1446~1449 (1972)
- Woolgar JA, "Histological distribution of cervical lymph node metastases from intraoral", oropharyngeal squamous cell carcinomas, 1999, pp.37, 175~180
- Woolgar JA, "Prediction of cervical lymph node metastasis in squamous cell carcinoma of the tongue", floor of mouth, 1995, pp.17, 463~472
- National Comprehensive Cancer Network (US), "The complete library of NCCN clinical practice guidelines in oncology" (2013), National Comprehensive Cancer Network