Clinical application of auto-tooth bone graft material
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Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinduction capacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission. Materials and Methods: Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillary sinus augmentation,and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011. Results: Clinical assessment: Among the 250 patients of auto-tooth bone graft, clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histological assessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated. Conclusion: Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.
Abstract
Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinduction capacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission. Materials and Methods: Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillary sinus augmentation,and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011. Results: Clinical assessment: Among the 250 patients of auto-tooth bone graft, clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histological assessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated. Conclusion: Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.
참고문헌 (18)
- Kim YK, "Development of a novel bone grafting material using autogenous teeth", ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 109, pp.496~503 (2010)
- Urist MR, "Bone: formation by autoinduction", Science, 150, pp.893~899 (1965)
- Murata M, "Bone induction of human tooth and bone crushed by newly developed automatic mill", J Ceram Soc Jpn, 118, pp.434~437 (2010)
- 김영균, "자가골과 BioOss.를 이용한 상악동골이식술: 자가골 함량에 따른 치유 비교", 대한구강악안면외과학회지, 33(6), pp.654~659 (2007), 대한구강악안면외과학회
- Quattlebaum JB, "Antigenicity of freezedried cortical bone allograft in human periodontal osseous defects", J Periodontol, 59, pp.394~397 (1988)
- Schwartz Z, "Ability of commercial demineralized freezedried bone allograft to induce new bone formation", J Periodontol, 67, pp.918~926 (1996)
- Sogal A, "Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications", J Periodontol, 70, pp.1053~1063 (1999)
- Han T, "Calcium phosphate ceramics in dentistry: a review of the literature", J West Soc Periodontol Periodontal Abstr, 32, pp.88~108 (1984)
- Park SS, "Osteogenic activity of the mixture of chitosan and particulate dentin.", J Biomed Mater Res A, 87, pp.618~623 (2008)
- Gomes MF, "Histologic evaluation of the osteoinductive property of autogenous demineralized dentin matrix on surgical bone defects in rabbit skulls using human amniotic membrane for guided bone regeneration", Int J Oral Maxillofac Implants, 16, pp.563~571 (2001)
- Catanzaro-Guimarãaes SA, "Osteogenic potential of autogenic demineralized dentin implanted in bony defects in dogs", Int J Oral Maxillofac Surg, 15, pp.160~169 (1986)
- Gongloff RK, "Vital root retention", Int J Oral Maxillofac Surg, 3, pp.97~99 (1974)
- Fareed K, "Vital root retention: a clinical procedure", J Prosthet Dent, 62, pp.430~434 (1989)
- Kim SG, "Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss) for bone regeneration in rats", J Craniomaxillofac Surg, 29, pp.282~288 (2001)
- Ike M, "Recycled dentin root matrix for a carrier of recombinant human bone morphogenetic protein", Oral Implantol, 24, pp.124~132 (1998)
- Goncalves EAL, "Study of the process of bone repair in surgical defects implanted with demineralized autogenous dentin matrix in radius of dog", pp.1997
- Gao J, "Expression of transforming growth factor-beta 1 (TGF-beta1) in the developing periodontium of rats", J Dent Res, 77, pp.1708~1716 (1998)
- Saygin NE, "Growth factors regulate expression of mineral associated genes in cementoblasts", J Periodontol, 71, pp.1591~1600 (2000)