Count of platelet and mean platelet volume score: serologic prognostic factor in patients with oral squamous cell carcinoma
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Objectives: TNM staging, especially for lymph node metastasis, is the scoring system most widely used among prognostic factors for cancer survival. Several biomarkers have been studied as serologic markers, but their specificity is low and clinical applications are difficult. This study aimed to estab-lish a scoring system for patients with oral squamous cell carcinoma (OSCC) using platelet (PLT) and mean platelet volume (MPV) levels measured postoperatively and to evaluate their significance as prognostic factors. Materials and Methods: We studied 40 patients admitted to the Department of Oral and Maxillofacial Surgery of Dankook University Hospital who were diagnosed with primary OSCC histopathologically between May 2006 and May 2012. Clinical pathological information obtained from the medi-cal records of each patient included age, sex, height, weight, tumor location, degree of differentiation, tumor diameter, lymph node metastasis, TNM stage, and other test values including white blood cell, MPV, PLT, C-reactive protein (CRP), and albumin obtained through a test conducted within 7 days before surgery. Count of platelet (COP)-MPV Score: Patients with both PLT and MPV values below the cut-off values were defined as score 0 (group A). Patients with at least one of the two higher than the cut-off value were defined as score 1 (group B).Results: Univariate analyses showed N-metastasis, COP-MPV (A vs B), PLT, platelet-lymphocyte ratio, and CRP were statistically significant prog-nostic factors. A multivariate Cox proportional hazards model showed N-metastasis (hazard ratio [HR] 6.227, P=0.016) and COP-MPV (A vs B) (HR 18.992, P=0.013) were independent prognostic factors with a significant effect on survival. Conclusion: COP-MPV score is a simple and cost-effective test method and is considered a more effective prognostic factor than other considered factors in predicting the prognosis of OSCC patients.
Abstract
Objectives: TNM staging, especially for lymph node metastasis, is the scoring system most widely used among prognostic factors for cancer survival. Several biomarkers have been studied as serologic markers, but their specificity is low and clinical applications are difficult. This study aimed to estab-lish a scoring system for patients with oral squamous cell carcinoma (OSCC) using platelet (PLT) and mean platelet volume (MPV) levels measured postoperatively and to evaluate their significance as prognostic factors. Materials and Methods: We studied 40 patients admitted to the Department of Oral and Maxillofacial Surgery of Dankook University Hospital who were diagnosed with primary OSCC histopathologically between May 2006 and May 2012. Clinical pathological information obtained from the medi-cal records of each patient included age, sex, height, weight, tumor location, degree of differentiation, tumor diameter, lymph node metastasis, TNM stage, and other test values including white blood cell, MPV, PLT, C-reactive protein (CRP), and albumin obtained through a test conducted within 7 days before surgery. Count of platelet (COP)-MPV Score: Patients with both PLT and MPV values below the cut-off values were defined as score 0 (group A). Patients with at least one of the two higher than the cut-off value were defined as score 1 (group B).Results: Univariate analyses showed N-metastasis, COP-MPV (A vs B), PLT, platelet-lymphocyte ratio, and CRP were statistically significant prog-nostic factors. A multivariate Cox proportional hazards model showed N-metastasis (hazard ratio [HR] 6.227, P=0.016) and COP-MPV (A vs B) (HR 18.992, P=0.013) were independent prognostic factors with a significant effect on survival. Conclusion: COP-MPV score is a simple and cost-effective test method and is considered a more effective prognostic factor than other considered factors in predicting the prognosis of OSCC patients.
참고문헌 (43)
- Siegel R, "Cancer statistics, 2013", CA Cancer J Clin, 63, pp.11~30 (2013)
- Ferlay J, "Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012", Int J Cancer, 136, pp.E359~E386 (2015)
- Johnson N, "Tobacco use and oral cancer: a global perspective", J Dent Educ, 65, pp.328~339 (2001)
- Reibel J, "Tobacco and oral diseases. Update on the evidence, with recommendations", Med Princ Pract, 12(Suppl 1), pp.22~32 (2003)
- Lewin F, "Smoking tobacco, oral snuff, and alcohol in the etiology of squamous cell carcinoma of the head and neck: a population-based case-referent study in Sweden", Cancer, 82, pp.1367~1375 (1998)
- Llewellyn CD, "Risk factors for squamous cell carcinoma of the oral cavity in young people--a comprehensive literature review", Oral Oncol, 37, pp.401~418 (2001)
- Singh B, "Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma", Head Neck, 20, pp.1~7 (1998)
- Schantz SP, "Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer", Arch Otolaryngol Head Neck Surg, 128, pp.268~274 (2002)
- Lydiatt DD, "Treatment of stage I and II oral tongue cancer", Head Neck, 15, pp.308~312 (1993)
- Layland MK, "The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+", Laryngoscope, 115, pp.629~639 (2005)
- Forastiere A, "Head and neck cancer", N Engl J Med, 345, pp.1890~1900 (2001)
- Woolgar JA, "Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection", Oral Oncol, 35, pp.257~265 (1999)
- Yotsukura S, "Evaluation of serum-based cancer biomarkers: a brief review from a clinical and computational viewpoint", Crit Rev Oncol Hematol, 93, pp.103~115 (2015)
- Lip GY, "Cancer and the prothrombotic state", Lancet Oncol, 3, pp.27~34 (2002)
- Nash GF, "Platelets and cancer", Lancet Oncol, 3, pp.425~430 (2002)
- Gay LJ, "Contribution of platelets to tumour metastasis", Nat Rev Cancer, 11, pp.123~134 (2011)
- Kamath S, "Platelet activation: assessment and quantification", Eur Heart J, 22, pp.1561~1571 (2001)
- Kai H, "Involvement of proinflammatory cytokines IL-1beta and IL-6 in progression of human gastric carcinoma", Anticancer Res, 25, pp.709~713 (2005)
- Kurt M, "The role of mean platelet volume in the diagnosis of hepatocellular carcinoma in patients with chronic liver disease", Hepatogastroenterology, 59, pp.1580~1582 (2012)
- Karaman K, "The predictive value of mean platelet volume in differential diagnosis of non-functional pancreatic neuroendocrine tumors from pancreatic adenocarcinomas", Eur J Intern Med, 22, pp.e95~e98 (2011)
- Kılınçalp S, "Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer", Platelets, 25, pp.592~594 (2014)
- Connolly GC, "Platelets and cancer-associated thrombosis", Semin Oncol, 41, pp.302~310 (2014)
- Stegner D, "Mechanistic explanation for platelet contribution to cancer metastasis", Thromb Res, 133(Suppl 2), pp.S149~S157 (2014)
- Caine GJ, "Platelet activation, coagulation and angiogenesis in breast and prostate carcinoma", Thromb Haemost, 92, pp.185~190 (2004)
- Li L, "sCD40L, sPselectin and sICAM-1 plasma levels in nasopharyngeal carcinoma", Sichuan Da Xue Xue Bao Yi Xue Ban, 40, pp.513~516 (2009)
- Peterson JE, "VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients", Angiogenesis, 15, pp.265~273 (2012)
- Azab B, "Mean platelet volume", platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction, 2011, pp.22, 557~566
- Slavka G, "Mean platelet volume may represent a predictive parameter for overall vascular mortality and ischemic heart disease", Arterioscler Thromb Vasc Biol, 31, pp.1215~1218 (2011)
- Cho SY, "Mean platelet volume", platelet count ratio in hepatocellular carcinoma, 2013, pp.24, 375~377
- Osada J, "Platelet activation in patients with advanced gastric cancer", Neoplasma, 57, pp.145~150 (2010)
- Mutlu H, "Alteration in mean platelet volume and platicrit values in patients with cancer that developed thrombosis", Clin Appl Thromb Hemost, 19, pp.331~333 (2013)
- Goldstein DP, "Head and neck squamous cell carcinoma in the young patient", Curr Opin Otolaryngol Head Neck Surg, 13, pp.207~211 (2005)
- Sarkaria JN, "Oral tongue cancer in young adults less than 40 years of age: rationale for aggressive therapy", Head Neck, 16, pp.107~111 (1994)
- Veness MJ, "Anterior tongue cancer: age is not a predictor of outcome and should not alter treatment", ANZ J Surg, 73, pp.899~904 (2003)
- Popovtzer A, "Squamous cell carcinoma of the oral tongue in young patients", Laryngoscope, 114, pp.915~917 (2004)
- Patel SC, "Increasing incidence of oral tongue squamous cell carcinoma in young white women, age 18 to 44 years", J Clin Oncol, 29, pp.1488~1494 (2011)
- Marocchio LS, "Oral squamous cell carcinoma: an analysis of 1,564 cases showing advances in early detection", J Oral Sci, 52, pp.267~273 (2010)
- Chow CW, "Squamous cell carcinomas in children and young adults: a new wave of a very rare tumor?", J Pediatr Surg, 42, pp.2035~2039 (2007)
- Zhang WB, "Cervical metastasis of maxillary squamous cell carcinoma", Int J Oral Maxillofac Surg, 44, pp.285~291 (2015)
- Zhang F, "Combination of platelet count and mean platelet volume (COP-MPV) predicts postoperative prognosis in both resectable early and advanced stage esophageal squamous cell cancer patients", Tumour Biol, 37, pp.9323~9331 (2016)
- Khandavilli SD, "Serum Creactive protein as a prognostic indicator in patients with oral squamous cell carcinoma", Oral Oncol, 45, pp.912~914 (2009)
- Gockel I, "Significance of preoperative C-reactive protein as a parameter of the perioperative course and long-term prognosis in squamous cell carcinoma and adenocarcinoma of the oesophagus", World J Gastroenterol, 12, pp.3746~3750 (2006)
- 박흥철, "C-reactive protein", albumin ratio as prognostic score in oral squamous cell carcinoma, 2016, pp.42(5), 243~250[DOI]