두경부 암 환자에서 수술 전 호중구-림프구 비율의 임상적 효용성
Impact of the Preoperative Neutrophil to Lymphocyte Ratio on Patients with Head and Neck Cancer
2
조회
0
다운로드
0
인용
0
참고문헌
초록
Background and Objectives To investigate the prognostic value of the neutrophil to lymphocyteratio (NLR) in patients with head and neck squamous cell cancer (HNSCC). Subjects and Method Clinical data from 259 patients with HNSCC were collected retrospectively. NLR was adopted as potential prognostic biomarkers. Results NLR was associated with cancer recurrence (p=0.002 and p＜0.001, respectively). Patients with a NLR ＞2.15 had significantly decreased 5-year disease specific survival (DSS)based on the Kaplan-Meier survival curves (p＜0.001 and p=0.029, respectively). The MultivariateCox regression analysis confirmed a significant association between 5-year DSS and theNLR (using 2.15 as the cut-off; hazard ratio, 1.852; 95% confidence interval, 1.237-2.771; p=0.003). Conclusion A NLR cut-off value ≥2.15 was associated with adverse outcomes in patientswith HNSCC.
Abstract
Background and Objectives To investigate the prognostic value of the neutrophil to lymphocyteratio (NLR) in patients with head and neck squamous cell cancer (HNSCC). Subjects and Method Clinical data from 259 patients with HNSCC were collected retrospectively. NLR was adopted as potential prognostic biomarkers. Results NLR was associated with cancer recurrence (p=0.002 and p＜0.001, respectively). Patients with a NLR ＞2.15 had significantly decreased 5-year disease specific survival (DSS)based on the Kaplan-Meier survival curves (p＜0.001 and p=0.029, respectively). The MultivariateCox regression analysis confirmed a significant association between 5-year DSS and theNLR (using 2.15 as the cut-off; hazard ratio, 1.852; 95% confidence interval, 1.237-2.771; p=0.003). Conclusion A NLR cut-off value ≥2.15 was associated with adverse outcomes in patientswith HNSCC.
참고문헌 (20)
- Jain S, "Prevention of head and neck cancer : Current status and future prospects", Curr Probl Cancer, 28(5), pp.265~286 (2004)
- "2015 Annual report of the Korea Central Cancer Registry" (2018)[URL]
- Dasgupta S, "Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients", Cancer Prev Res(Phila), 3(9), pp.1205~1211 (2010)
- Lee JM, "Economic burden of head and neck cancer. A literature review", Eur J Health Econ, 5(1), pp.70~80 (2004)
- Grivennikov SI, "Immunity, inflammation, and cancer", Cell, 140(6), pp.883~899 (2010)
- Pei D, "Pre-adjuvant chemotherapy leukocyte count may predict the outcome for advanced gastric cancer after radical resection", Biomed Pharmacother, 68(2), pp.213~217 (2014)
- Tsai YD, "Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer", Head Neck, 36(7), pp.947~953 (2014)
- Ishizuka M, "Combination of platelet count and neutrophil to lymphocyte ratio is a useful predictor of postoperative survival in patients with colorectal cancer", Br J Cancer, 109(2), pp.401~407 (2013)
- Rachidi S, "Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma", J Hematol Oncol, 7, pp.65~ (2014)
- Templeton AJ, "Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors : A systematic review and meta-analysis", J Natl Cancer Inst, 106(6), pp.dju124~ (2014)
- Tecchio C, "On the cytokines produced by human neutrophils in tumors", Semin Cancer Biol, 23(3), pp.159~170 (2013)
- Azab B, "Usefulness of the neutrophil-to-lymphocyte ratio in predicting short-and long-term mortality in breast cancer patients", Ann Surg Oncol, 19(1), pp.217~224 (2012)
- Halazun KJ, "Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma", Ann Surg, 250(1), pp.141~151 (2009)
- Jung MR, "Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer", J Surg Oncol, 104(5), pp.504~510 (2011)
- Gomez D, "Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma", World J Surg, 32(8), pp.1757~1762 (2008)
- Walsh SR, "Neutrophillymphocyte ratio as a prognostic factor in colorectal cancer", J Surg Oncol, 91(3), pp.181~184 (2005)
- Ali AA, "Tumour T-lymphocyte subset infiltration and tumour recurrence following curative resection for colorectal cancer", Eur J Surg Oncol, 30(3), pp.292~295 (2004)
- Sun W, "Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma : Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio", Head Neck, 38(Suppl 1), pp.E1332~E1340 (2016)
- Song Y, "Preoperative neutrophilto-lymphocyte ratio as prognostic predictor for hypopharyngeal squamous cell carcinoma after radical resections", J Craniofac Surg, 26(2), pp.e137~40 (2015)
- Sarraf KM, "Neutrophil", lymphocyte ratio and its association with survival after complete resection in non-small cell lung cancer, 2009, pp.137(2), 425~428