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Protocol for management of odontogenic keratocysts considering recurrence according to treatment methods

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초록

The management of odontogenic keratocysts (OKC) remains a hotly debated topic in oral and maxillofacial surgery. Despite numerous studies and systematic reviews on treatment options, there is a lack of consensus and no accepted protocol on the management of OKC. Hence, the aim of this study was to briefly summarize all large systematic reviews in the literature on the management of OKC and formulate an evidence-based management protocol. Data from five large systematic reviews were combined to calculate the mean recurrence rate for each technique. Decompression followed by enucleation along with adjuvant methods such as application of Carnoy’s solution and peripheral ostectomy can result in very low recurrence and is an acceptable first line treatment. The surgical approach should be determined by lesion size, patient age, proximity to vital structures, accessibility, soft tissue/cortical perforation, and if the lesion is recurrent.

Abstract

The management of odontogenic keratocysts (OKC) remains a hotly debated topic in oral and maxillofacial surgery. Despite numerous studies and systematic reviews on treatment options, there is a lack of consensus and no accepted protocol on the management of OKC. Hence, the aim of this study was to briefly summarize all large systematic reviews in the literature on the management of OKC and formulate an evidence-based management protocol. Data from five large systematic reviews were combined to calculate the mean recurrence rate for each technique. Decompression followed by enucleation along with adjuvant methods such as application of Carnoy’s solution and peripheral ostectomy can result in very low recurrence and is an acceptable first line treatment. The surgical approach should be determined by lesion size, patient age, proximity to vital structures, accessibility, soft tissue/cortical perforation, and if the lesion is recurrent.

참고문헌 (10)

  1. Al-Moraissi EA, "What surgical treatment has the lowest recurrence rate following the management of keratocystic odontogenic tumor? : a large systematic review and meta-analysis", J Craniomaxillofac Surg, 45, pp.131~144 (2017)[DOI]
  2. Pogrel MA, "The keratocystic odontogenic tumor", Oral Maxillofac Surg Clin North Am, 25, pp.21~30 (2013)[DOI]
  3. Nobuyoshi Tomomatsu, "Clinical study of keratocystic odontogenic tumors", 대한구강악안면외과학회지, 38(1), pp.56~63 (2012), 대한구강악안면외과학회
  4. de Castro MS, "Conservative surgical treatments for nonsyndromic odontogenic keratocysts: a systematic review and meta-analysis", Clin Oral Investig, 22, pp.2089~2101 (2018)[DOI]
  5. Johnson NR, "Management and recurrence of keratocystic odontogenic tumor : a systematic review", Oral Surg Oral Med Oral Pathol Oral Radiol, 116, pp.e271~e276 (2013)[DOI]
  6. Kaczmarzyk T, "A systematic review of the recurrence rate for keratocystic odontogenic tumour in relation to treatment modalities", Int J Oral Maxillofac Surg, 41, pp.756~767 (2012)[DOI]
  7. Chrcanovic BR, "Recurrence probability for keratocystic odontogenic tumors : an analysis of 6427 cases", J Craniomaxillofac Surg, 45, pp.244~251 (2017)[DOI]
  8. van Rensburg LJ, "Correlative MRI and CT imaging of the odontogenic keratocyst : a review of twenty-one cases", Oral Maxillofac Surg Clin North Am, 15, pp.363~382 (2003)[DOI]
  9. Al-Moraissi EA, "Does the excision of overlying oral mucosa reduce the recurrence rate in the treatment of the keratocystic odontogenic tumor? A systematic review and meta-analysis", J Oral Maxillofac Surg, 74, pp.1974~1982 (2016)[DOI]
  10. Titinchi F, "Keratocystic odontogenic tumor: a recurrence analysis of clinical and radiographic parameters", Oral Surg Oral Med Oral Pathol Oral Radiol, 114, pp.136~142 (2012)[DOI]

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