Efficacy of submucosal injection of hyaluronidase after mandibular third molar surgery: a randomized controlled trial
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Objectives: This study aimed to investigate the efficacy of postoperative submucosal injection of hyaluronidase (HUD) for reducing sequelae and quality of life (QOL) after mandibular third molar (M3M) surgery. Materials and Methods: Participants with bilateral impacted M3M underwent surgical extraction with a split-mouth randomized controlled study design. M3M were removed by the same surgeon in 2 sessions, one a control and the other experimental. Submucosal injection of HUD was performed in the experimental session and submucosal injection of saline in the control session. Mouth opening, facial swelling, and pain intensity were measured before surgery, and then 2 and 7 days after surgery. The QOL of participants following surgery was evaluated by means of a patient-centered outcome questionnaire (PCOQ). Results: A total of 36 patients was included in the final data analysis. There was a significant reduction in the maximal mouth opening and postopera-tive pain in the experimental side at the 2 and 7 days after surgery (P<0.05), and a remarkable difference in facial swelling was reported on the experi-mental side 7 days after surgery (P<0.05). The PCOQ demonstrated that participants reported less pain and swelling on the experimental side. Conclusion: The present study provides clinical evidence that submucosal administration of HUD immediately after M3M surgery reduced postop-erative discomfort and improved patients’ QOL.
Abstract
Objectives: This study aimed to investigate the efficacy of postoperative submucosal injection of hyaluronidase (HUD) for reducing sequelae and quality of life (QOL) after mandibular third molar (M3M) surgery. Materials and Methods: Participants with bilateral impacted M3M underwent surgical extraction with a split-mouth randomized controlled study design. M3M were removed by the same surgeon in 2 sessions, one a control and the other experimental. Submucosal injection of HUD was performed in the experimental session and submucosal injection of saline in the control session. Mouth opening, facial swelling, and pain intensity were measured before surgery, and then 2 and 7 days after surgery. The QOL of participants following surgery was evaluated by means of a patient-centered outcome questionnaire (PCOQ). Results: A total of 36 patients was included in the final data analysis. There was a significant reduction in the maximal mouth opening and postopera-tive pain in the experimental side at the 2 and 7 days after surgery (P<0.05), and a remarkable difference in facial swelling was reported on the experi-mental side 7 days after surgery (P<0.05). The PCOQ demonstrated that participants reported less pain and swelling on the experimental side. Conclusion: The present study provides clinical evidence that submucosal administration of HUD immediately after M3M surgery reduced postop-erative discomfort and improved patients’ QOL.
참고문헌 (34)
- Duarte-Rodrigues L, "Third molar removal and its impact on quality of life : systematic review and meta-analysis", Qual Life Res, 27, pp.2477~2489 (2018)[DOI]
- Majid OW, "Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery : a randomized, double-blind, placebocontrolled clinical trial", J Oral Maxillofac Surg, 72, pp.1043~1048 (2014)[DOI]
- Al-Dajani M, "Can preoperative intramuscular single-dose dexamethasone improve patient-centered outcomes following third molar surgery?", J Oral Maxillofac Surg, 75, pp.1616~1626 (2017)[DOI]
- Xie L, "Does low dose of etoricoxib play pre-emptive analgesic effect in third molar surgery? A randomized clinical trial", BMC Oral Health, 21, pp.462~ (2021)[DOI]
- Lim D, "A comparative study on the efficacy of submucosal injection of dexamethasone versus methylprednisolone in reducing postoperative sequelae after third molar surgery", J Oral Maxillofac Surg, 75, pp.2278~2286 (2017)[DOI]
- Chollathit Sugragan, "Do corticosteroids reduce postoperative pain following third molar intervention?", Journal of Dental Anesthesia and Pain Medicine, 20(5), pp.281~291 (2020), 대한치과마취과학회[DOI]
- Buhren BA, "Hyaluronidase : from clinical applications to molecular and cellular mechanisms", Eur J Med Res, 21, pp.5~ (2016)[DOI]
- Fronza M, "Hyaluronidase decreases neutrophils infiltration to the inflammatory site", Inflamm Res, 65, pp.533~542 (2016)[DOI]
- Satish SV, "Comparative evaluation of the efficacy of 2% lidocaine containing 1 : 200, 000 epinephrine with and without hyaluronidase(75 IU)in patients with irreversible pulpitis", J Endod, 39, pp.1116~1118 (2013)[DOI]
- Fronza M, "Hyaluronidase modulates inflammatory response and accelerates the cutaneous wound healing", PLoS One, 9, pp.e112297~ (2014)[DOI]
- Wu L, "Delayed allergic hypersensitivity to hyaluronidase during the treatment of granulomatous hyaluronic acid reactions", J Cosmet Dermatol, 17, pp.991~995 (2018)[DOI]
- Venkatesh KH, "Treatment of supraglottic airway edema by local hyaluronidase", Anesthesiology, 106, pp.1254~1255 (2007)[DOI]
- Henkel GH, "The role and applicability of hyaluronidase in clinical dentistry", Oral Surg Oral Med Oral Pathol, 9, pp.463~492 (1956)[DOI]
- Winter GB, "Principles of exodontia as applied to the impacted mandibular third molar: a complete treatise on the operative technic with clinical diagnoses and radiographic interpretations" (1926), American medical Book Company
- Pell GJ, "Report on a ten-year study of a tooth division technique for the removal of impacted teeth", Am J Orthod Oral Surg, 28, pp.B660~B666 (1942)[DOI]
- Pederson GW, "Oral surgery" (1988), WB Saunders
- Slade GD, "Development and evaluation of the oral health impact profile", Community Dent Health, 11, pp.3~11 (1994)
- Koçer G, "Effect of the route of administration of methylprednisolone on oedema and trismus in impacted lower third molar surgery", Int J Oral Maxillofac Surg, 43, pp.639~643 (2014)[DOI]
- Warraich R, "Evaluation of postoperative discomfort following third molar surgery using submucosal dexamethasone-a randomized observer blind prospective study", Oral Surg Oral Med Oral Pathol Oral Radiol, 116, pp.16~22 (2013)[DOI]
- Bilginaylar K, "Evaluation of the effects of platelet-rich fibrin and piezosurgery on outcomes after removal of ımpacted mandibular third molars", Br J Oral Maxillofac Surg, 54, pp.629~633 (2016)[DOI]
- Starzyńska A, "The growth factors in advanced platelet-rich fibrin(A-PRF)reduce postoperative complications after mandibular third molar odontectomy", Int J Environ Res Public Health, 18, pp.13343~ (2021)[DOI]
- Eshghpour M, "Is low-level laser therapy effective in the management of pain and swelling after mandibular third molar surgery?", J Oral Maxillofac Surg, 74, pp.1322.e1~1322.e8 (2016)[DOI]
- Min-Jeong Kwoen, "Efficacy of local hyaluronidase administration in guided bone regeneration surgery: a randomized controlled trial", 대한구강악안면외과학회지, 47(2), pp.91~98 (2021), 대한구강악안면외과학회[DOI]
- Kim JH, "The efficacy of hyaluronidase in early surgery of nasal bone fracture", J Craniofac Surg, 30, pp.e617~e619 (2019)[DOI]
- Smaïl-Faugeron V, "Comparison of intervention effects in split-mouth and parallel-arm randomized controlled trials : a meta-epidemiological study", BMC Med Res Methodol, 14, pp.64~ (2014)[DOI]
- Koç O, "Can hyaluronidase be an alternative postoperative anti-edema agent to dexamethasone? Preliminary results of an animal study", J Oral Maxillofac Surg, 76, pp.1653~1659 (2018)[DOI]
- Nekoroski T, "A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema", Int J Dermatol, 53, pp.777~785 (2014)[DOI]
- 한진호, "Treatment of post-traumatic hematoma and fibrosis using hyaluronidase injection", Archives of Craniofacial Surgery, 19(3), pp.218~221 (2018), 대한두개안면성형외과학회[DOI]
- James L, "Management of oral submucous fibrosis with injection of hyaluronidase and dexamethasone in grade III oral submucous fibrosis : a retrospective study", J Int Oral Health, 7, pp.82~85 (2015)
- Delaere L, "Allergic reaction to hyaluronidase after retrobulbar anaesthesia : a case series and review", Int Ophthalmol, 29, pp.521~528 (2009)[DOI]
- Kim MS, "Allergic reaction to hyaluronidase use after hyaluronic acid filler injection", J Cosmet Laser Ther, 17, pp.283~285 (2015)[DOI]
- 김태완, "Allergic reactions to hyaluronidase in pain management -A report of three cases-", Korean Journal of Anesthesiology, 60(1), pp.57~59 (2011), 대한마취통증의학회
- Bailey SH, "Changing role of hyaluronidase in plastic surgery", Plast Reconstr Surg, 133, pp.127e~132e (2014)[DOI]
- Zamora-Alejo K, "Hyaluronidase toxicity : a possible cause of postoperative periorbital inflammation", Clin Exp Ophthalmol, 41(2), pp.122~126 (2013)[DOI]
