대퇴골두 무혈성 괴사의 비수술적 관절보존 치료
Joint Preserving Non-surgical Treatment of Osteonecrosis of Femoral Head
1
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
대퇴골두 무혈성 괴사를 처음 진단 시에는 환자나 의사 모두 가능한 관절을 보존하는 방법을 가장 먼저 고려하고 궁극적인 성취 목표로 설정하게 되나, 다양한 인자로 인한 질병으로 지엽적인 병리학적 분석에 따른 원인에 대한 단순한 치료적 접근으로는 소기의 목적을 달성하는 것이 어렵다. 이러한 대퇴골두 무혈성 괴사의 자연 경과는 컴퓨터 단층촬영, 골 주사 혹은 자기공명영상과 같은 영상기술의발달로 다수의 예후인자들이 연구됨으로써, 이에 근거한 보다 정확하고 과학적 측면에서 객관적인 예 후 판단이 가능하게 되었다. 대다수의 대퇴골두 무혈성 괴사의 호발 연령은 20-50대의 청장년층이기 때문에 일차적으로 통증만을 해소하려는 것을 목표로 하여 무조건 수술적 치료 특히 인공관절 치환을 시행하는 것은 바람직하지 않다. 따라서 초기의 경우에는 이차적인 퇴행성 관절을 방지하고 관절을 보존하는 측면에서 접근하여야 하는 다양한 시도가 현재 실험적 혹은 임상적 측면에서 이루어지고 있다. 본문에서는 초기의 대퇴골두 무혈성 괴사에서 실험적 혹은 임상적 측면에서 시행되고 있는 비수술적 관절 보존 치료법을 고찰하고자 한다.
Abstract
A patient and physician initially consider how to preserve a joint, and make a goal to achieve this aim when osteonecrosis is initially diagnosed. On the other hand, it is almost imposs able to make a decision with only a herapeutic approach based on the pathology, because osteonecrosis of the femoral head is caused by a range of factors. An objective prognosis has now become possible due to the development of radiologic diagnostic assessment tools, such as CT, bone scans and MRI. Most osteonecrosis patients are in their 20-50’s. Therefore, physicians make a primary goal to control pain. The surgical approach, such as total joint replacement, is not the first option for early stage osteonecrosis. In the first stage, osteonecrosis should be treated to prevent secondary degenerative diseases and preserve the hip joint. This paper introduces a non-surgical joint preserving treatment in scientific and clinical aspects for early stage osteonecrosis.
참고문헌 (46)
- Lafforgue P, "Early-stage avascular necrosis of the femoral head: MR imaging for prognosis in 31 cases with at least 2 years of follow-up", Radiology, 187, pp.199~204 (1993)
- Mont MA, "Non-traumatic avascular necrosis of the femoral head", J Bone Joint Surg Am, 77, pp.459~474 (1995)
- Ohzono K, "Natural history of nontraumatic avascular necrosis of the femoral head", J Bone Joint Surg Br, 73, pp.68~72 (1991)
- Lieberman JR, "Osteonecrosis of the hip: management in the 21st century", Instr Course Lect, 52, pp.337~355 (2003)
- Assouline-Dayan Y, "Pathogenesis and natural history of osteonecrosis", Semin Arthritis Rheum, 32, pp.94~124 (2002)
- Merle D'Aubigne R, "Idiopathic necrosis of the femoral head in adults", J Bone Joint Surg Br, 47, pp.612~633 (1965)
- Ficat RP, "Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment", J Bone Joint Surg Br, 67, pp.3~9 (1985)
- Hughes DE, "Inhibition of osteoclast-like cell formation by bisphophonates in long-term cultures of human bone marrow", J Clin Invest, 83, pp.1930~1935 (1989)
- Koo KH, "Quantifying the extent of osteonecrosis of the femoral head. A new method using MRI", J Bone Joint Surg Br, 77, pp.875~880 (1995)
- Sugano N, "The 2001 revised criteria for diagnosis, classification, and staging of idiopathic osteonecrosis of the femoral head", J Orthop Sci, 7, pp.601~605 (2002)
- Marcus ND, "The silent hip in idiopathic aseptic necrosis. Treatment by bone-grafting", J Bone Joint Surg Am, 55, pp.1351~1366 (1973)
- Steinberg ME, "A quantitative system for staging avascular necrosis", J Bone Joint Surg Br, 77, pp.34~41 (1995)
- Gardeniers JWM, "The ARCO perspective for reaching one uniform staging system of osteonecrosis, In Bone circulation and vascularization in normal and pathological conditions", pp.375~380 (1993), Plenum Press
- Hungerford DS, "Asymptomatic osteonecrosis: should it be treated?", Clin Orthop Relat Res, (429), pp.124~130 (2004)
- Nishii T, "Significance of lesion size and location in the prediction of collapse of osteonecrosis of the femoral head: a new three-dimensional quantification using magnetic resonance imaging", J Orthop Res, 20, pp.130~136 (2002)
- Stulberg BN, "Osteonecrosis of the femoral head. A prospective randomized treatment protocol", Clin Orthop Relat Res, (268), pp.140~151 (1991)
- 송해룡, "Bone marrow edema and associated pain in early stage osteonecrosis of the femoral head: Prospective study with serial MR images", RADIOLOGY, 213, pp.715~722 (1999), RADIOLOGICAL SOC NORTH AMERICA
- Belmar CJ, "Does pain predict outcome in hips with osteonecrosis?", Clin Orthop Relat Res, 425, pp.158~162 (2004)
- Nam KW, "Fate of untreated asymptomatic osteonecrosis of the femoral head", J Bone Joint Surg Am, 90, pp.477~484 (2008)
- Mont MA, "Osteonecrosis: strategies for treatment, In The adult hip. 2nd ed", pp.477~499 (2007), Lippincott Williams & Wilkins
- Cui Q, "The Otto Aufranc Award. Lovastatin prevents steroid induced adipogenesis and osteonecrosis", Clin Orthop Relat Res, (344), pp.8~19 (1997)
- Motomura G, "Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits", Arthritis Rheum, 50, pp.3387~3391 (2004)
- Nagasawa K, "Prevention of steroid-induced osteonecrosis of femoral head in systemic lupus erythematosus by anti-coagulant", Lupus, 15, pp.354~357 (2006)
- Pritchett JW, "Statin therapy decreases the risk of osteonecrosis in patients receiving steroids", Clin Orthop Relat Res, (386), pp.173~178 (2001)
- Yang C, "Vascular endothelial growth factor gene transfection to enhance the repair of avascular necrosis of the femoral head of rabbit", Chin Med J, 116, pp.1544~1548 (2003)
- Chen CH, "Alendronate in the prevention of collapse of the femoral head in nontraumatic osteonecrosis: a two-year multicenter, prospective, randomized, double-blind, placebo-controlled study", Arthritis Rheum, 64, pp.1572~1578 (2012)
- Rajpura A, "Medical management of osteonecrosis of the hip: a review", Hip Int, 21, pp.385~392 (2011)
- Murakami H, "A possible mechanism of specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders", Bone, 17, pp.137~144 (1995)
- Hughes DE, "Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo", J Bone Miner Res, 10, pp.1478~1487 (1995)
- Sahni M, "Bisphosphonates act on rat bone resorption through the mediation of osteoblasts", J Clin Invest, 91, pp.2004~2011 (1993)
- Astrand J, "Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats", BMC Musculoskelet Disord, 3, pp.19~ (2002)
- Little DG, "Zoledronic acid treatment results in retention of femoral head structure after traumatic osteonecrosis in young Wistar rats", J Bone Miner Res, 18, pp.2016~2022 (2003)
- Kim HK, "Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs", J Bone Joint Surg Am, 87, pp.550~557 (2005)
- Agarwala S, "Efficacy of alendronate, a bisphosphonate, in the treatment of AVN of the hip. A prospective open-label study", Rheumatology, 44, pp.352~359 (2005)
- Lai KA, "The use of alendronate to prevent early collapse of the femoral head in patients with nontraumatic osteonecrosis. A randomized clinical study", J Bone Joint Surg Am, 87, pp.2155~2159 (2005)
- Nishii T, "Does alendronate prevent collapse in osteonecrosis of the femoral head?", Clin Orthop Relat Res, (443), pp.273~279 (2006)
- Yarom N, "Osteonecrosis of the jaw induced by orally administered bisphosphonates: incidence, clinical features, predisposing factors and treatment outcome", Osteoporos Int, 18, pp.1363~1370 (2007)
- Wang GJ, "The Nicolas Andry award. The pathogenesis and prevention of steroid-induced osteonecrosis", Clin Orthop Relat Res, (370), pp.295~310 (2000)
- Glueck CJ, "Enoxaparin prevents progression of stages I and II osteonecrosis of the hip", Clin Orthop Relat Res, (435), pp.164~170 (2005)
- Bassett CA, "Effects of pulsed electromagnetic fields on Steinberg ratings of femoral head osteonecrosis", Clin Orthop Relat Res, (246), pp.172~185 (1989)
- Massari L, "Biophysical stimulation with pulsed electromagnetic fields in osteonecrosis of the femoral head", J Bone Joint Surg Am, 88(Suppl 3), pp.56~60 (2006)
- Reis ND, "Hyperbaric oxygen therapy as a treatment for stage-I avascular necrosis of the femoral head", J Bone Joint Surg Br, 85, pp.371~375 (2003)
- Heinrichs W, "Extracorporeal shock-wave therapy (ESWT) for pseudoarthrosis. A new indication for regional anesthesia", Anaesthesist, 42, pp.361~364 (1993)
- Ludwig J, "High-energy shock wave treatment of femoral head necrosis in adults", Clin Orthop Relat Res, (387), pp.119~126 (2001)
- Wang CJ, "Treatment for osteonecrosis of the femoral head: comparison of extracorporeal shock waves with core decompression and bone-grafting", J Bone Joint Surg Am, 87, pp.2380~2387 (2005)
- Katsube K, "Vascular endothelial growth factor (VEGF) gene transfer enhances surgical revascularization of necrotic bone", J Orthop Res, 23, pp.469~474 (2005)
