광범위베타락탐아제 생성 Escherichia coli와 Klebsiellapneumoniae의 piperacillin/tazobactam에 대한 시험관내 감수성
In Vitro Susceptibility of piperacillin/tazobactam Against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
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Minimal inhibitory concentrations (MIC) of piperacillin/tazobactam were determined on 20 clinical isolates of extended-spectrum β-lactamase (ESBL)-producing E. coli and 30 isolates of ESBL- producing Klebsiella pneumoniae. MIC50 and MIC90 for ESBL-producing E. coli were 8/4 µg/ml and 256/4 µg/mL, respectively. MIC50 and MIC90 for ESBL-producing K. pneumoniae were 8/4 µg/mL and ＞512/4 µg/mL, respectively. The susceptibilities of ESBL-producing E. coli and K. pneumoniae to piperacillin/tazobactam were 80% and 60%, respectively. Of 20 ESBL-producing E. coli strains, 11 (55%) were TEM-and CTX-M-positive, and SHV-negative. Of 30 ESBL-producing K. pneumoniae strains, ten (33%) were PCR positive for SHV and negative for TEM and CTX-M.
Abstract
Minimal inhibitory concentrations (MIC) of piperacillin/tazobactam were determined on 20 clinical isolates of extended-spectrum β-lactamase (ESBL)-producing E. coli and 30 isolates of ESBL- producing Klebsiella pneumoniae. MIC50 and MIC90 for ESBL-producing E. coli were 8/4 µg/ml and 256/4 µg/mL, respectively. MIC50 and MIC90 for ESBL-producing K. pneumoniae were 8/4 µg/mL and ＞512/4 µg/mL, respectively. The susceptibilities of ESBL-producing E. coli and K. pneumoniae to piperacillin/tazobactam were 80% and 60%, respectively. Of 20 ESBL-producing E. coli strains, 11 (55%) were TEM-and CTX-M-positive, and SHV-negative. Of 30 ESBL-producing K. pneumoniae strains, ten (33%) were PCR positive for SHV and negative for TEM and CTX-M.
참고문헌 (8)
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