Splenic Infarction Associated with Brucellosis in a Non-Endemic Area
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
A 45-year-old man was referred from a local clinic with persistent fever, intermittent pain in the left upper abdomen, and weight loss of 7 kg. He quit his animal husbandry 18 months ago when his cows were found to be infected with Brucella. Abdominal computed tomography (CT) scan taken on admission showed splenomegaly with a wedge-shaped hypoattenuating region in the enhanced image, which was consistent with splenic infarction. Serology for Bruculla was strongly positive with the standard tube agglutination test (1/2560). After initiation of doxycycline (100 mg every 12 hrs) and rifampin (600 mg every day), the patient’s condition improved, and was discharged with oral antibiotics that were to be continued for 3 months. During the 12 months’ follow up at the outpatient department, the patient had no symptoms, and the last agglutination titer for Brucella in serum had decreased to 1/40. To our knowledge, this is the first report on splenic infarction associated with brucellosis in Korea, which was treated successfully with antibiotic therapy.
Abstract
A 45-year-old man was referred from a local clinic with persistent fever, intermittent pain in the left upper abdomen, and weight loss of 7 kg. He quit his animal husbandry 18 months ago when his cows were found to be infected with Brucella. Abdominal computed tomography (CT) scan taken on admission showed splenomegaly with a wedge-shaped hypoattenuating region in the enhanced image, which was consistent with splenic infarction. Serology for Bruculla was strongly positive with the standard tube agglutination test (1/2560). After initiation of doxycycline (100 mg every 12 hrs) and rifampin (600 mg every day), the patient’s condition improved, and was discharged with oral antibiotics that were to be continued for 3 months. During the 12 months’ follow up at the outpatient department, the patient had no symptoms, and the last agglutination titer for Brucella in serum had decreased to 1/40. To our knowledge, this is the first report on splenic infarction associated with brucellosis in Korea, which was treated successfully with antibiotic therapy.
참고문헌 (15)
- Young EJ, "An overview of human brucellosis", Clin Infect Dis, 21, pp.283~289 (1995)
- Reguera JM, "Brucella endocarditis: clinical, diagnostic, and therapeutic approach", Eur J Clin Microbiol Infect Dis, 22, pp.647~650 (2003)
- 김연숙, "국내에서 발생하고 있는 사람 브��셀라증의 임상적 특성", Infection and Chemotherapy, 38(6), pp.334~343 (2006), 대한감염학회
- Sang Hyun Park, "Brucella Endocarditis with Splenic Abscess: A Report of the First Case Diagnosed in Korea", Yonsei Medical Journal, 50(1), pp.142~146 (2009), 연세대학교의과대학
- 강용운, "다발성 골수종 환자에서 척추염을 동반한 브루셀라 심내막염", 대한내과학회지, 74(5), pp.561~565 (2008), 대한내과학회
- Je HG, "Brucella endocarditis in a non-endemic country: first reported case in East Asia", Circ J, 72, pp.500~501 (2008)
- Cakalagaoglu C, "Brucella-mediated prosthetic valve endocarditis with brachial artery mycotic aneurysm", J Heart Valve Dis, 8, pp.586~590 (1999)
- Zaidan R, "Cerebral venous thrombosis: a new manifestation of neurobrucellosis", Clin Infect Dis, 28, pp.399~400 (1999)
- Salgado F, "Splenic infarction associated with acute Brucella mellitensis infection", Eur J Clin Microbiol Infect Dis, 21, pp.63~64 (2002)
- Yaqupsky P, "Detection of Brucella in blood cultures", J Clin Microbiol, 37, pp.3437~3442 (1999)
- Ariza J, "Specific antibody profile in human brucellosis", Clin Infect Dis, 14, pp.131~140 (1992)
- Joshi SC, "Splenic infarct as a diagnostic pitfall in radiology", J Cancer Res Ther, 4, pp.99~101 (2008)
- Rabushka LS, "Imaging of the spleen: CT with supplemental MR examination", Radiographics, 14, pp.307~332 (1994)
- Noval J, "Splenic infarction in a patient with anticardiolipin antibodies and leptospirosis", Enferm Infecc Microbiol Clin, 17, pp.98~99 (1999)
- Solera J, "Recognition and optimum treatment of brucellosis", Drugs, 53, pp.245~256 (1997)