Clinical Characteristic of Respiratory Tract Infections in Children during Pandemic Influenza (H1N1 2009) in Korea
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Background: Since initial emergence on pandemic influenza (H1N1 2009) in Mexico on March 2009, the first case of pandemic influenza (H1N1 2009) occured on 2 May 2009 in Korea. We describe the clinical characteristics of childhood patients from pandemic influenza (H1N1 2009) and other concurrent respiratory pathogens during early phase of the pandemic influenza in Korea. Materials and Methods: We have retrospectively studied 959 patients under age of 15 years who have visited Department of Emergency Medicine for a diagnostic test of pandemic influenza (H1N1 2009) or treatment of flu-like illness between May and September of 2009. The pandemic influenza (H1N1 2009) was detected via realtime RT-PCR and other respiratory viruses were detected via multiplex RT-PCR. Results: A total of 959 patients visited Department of Emergency Medicine at Severance Hospital. Of them, 562 were tested; 124 (12.7%) were positive for pandemic influenza (H1N1 2009). Confirmed patients of pandemic influenza (H1N1 2009) were relatively older than non-H1N1 patients (7.5 years of age vs 4.6 years, P<0.001). Among histories or symptoms of patients with flu-like illness,contact history (80%) with another patient with pandemic influenza (H1N1 2009)was an important clue of the infection in early phase of pandemic. Comparing with hospitalized patients with respiratory tract infections due to other causes, lower ESR (32.9±23.5 mm/hour vs 11.5±9.2 mm/hour), hyperkalemia (4.2±0.3 mmol/L vs 5.2±3 mmol/L) and hyponatremia (137.2±2.5 mmol/L vs 124±40.5 mmol/L)were significant laboratory finding and higher cholesterol and GTP were noticed in pandemic influenza (H1N1 2009). Ten confirmed patients with pandemic influenza (H1N1 2009) were hospitalized due to pneumonia and all of them were resolved without any complication. Conclusions: Respiratory tract infections were caused not only by pandemic influenza (H1N1 2009) virus but also various respiratory viruses. Hospitalized patients, confirmed as pandemic influenza (H1N1 2009), showed a good prognosis. Age and contact history were distinct features and could be an important clue to differentiate causes in patients with febrile respiratory symptoms.
Abstract
Background: Since initial emergence on pandemic influenza (H1N1 2009) in Mexico on March 2009, the first case of pandemic influenza (H1N1 2009) occured on 2 May 2009 in Korea. We describe the clinical characteristics of childhood patients from pandemic influenza (H1N1 2009) and other concurrent respiratory pathogens during early phase of the pandemic influenza in Korea. Materials and Methods: We have retrospectively studied 959 patients under age of 15 years who have visited Department of Emergency Medicine for a diagnostic test of pandemic influenza (H1N1 2009) or treatment of flu-like illness between May and September of 2009. The pandemic influenza (H1N1 2009) was detected via realtime RT-PCR and other respiratory viruses were detected via multiplex RT-PCR. Results: A total of 959 patients visited Department of Emergency Medicine at Severance Hospital. Of them, 562 were tested; 124 (12.7%) were positive for pandemic influenza (H1N1 2009). Confirmed patients of pandemic influenza (H1N1 2009) were relatively older than non-H1N1 patients (7.5 years of age vs 4.6 years, P<0.001). Among histories or symptoms of patients with flu-like illness,contact history (80%) with another patient with pandemic influenza (H1N1 2009)was an important clue of the infection in early phase of pandemic. Comparing with hospitalized patients with respiratory tract infections due to other causes, lower ESR (32.9±23.5 mm/hour vs 11.5±9.2 mm/hour), hyperkalemia (4.2±0.3 mmol/L vs 5.2±3 mmol/L) and hyponatremia (137.2±2.5 mmol/L vs 124±40.5 mmol/L)were significant laboratory finding and higher cholesterol and GTP were noticed in pandemic influenza (H1N1 2009). Ten confirmed patients with pandemic influenza (H1N1 2009) were hospitalized due to pneumonia and all of them were resolved without any complication. Conclusions: Respiratory tract infections were caused not only by pandemic influenza (H1N1 2009) virus but also various respiratory viruses. Hospitalized patients, confirmed as pandemic influenza (H1N1 2009), showed a good prognosis. Age and contact history were distinct features and could be an important clue to differentiate causes in patients with febrile respiratory symptoms.
참고문헌 (19)
- Perez-Padilla R, "INER Working Group on Influenza. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico", N Engl J Med, 361, pp.680~689 (2009)
- Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, "Emergence of a novel swine-origin influenza A (H1N1) virus in humans", N Engl J Med, 360, pp.2605~2615 (2009)
- "Epidemiologic character ist ics of inf luenza A (H1N1) 2009 conf irmed cases in Korea"[URL]
- Chowell G, "Severe respiratory disease concurrent with the circulation of H1N1 influenza", N Engl J Med, 361, pp.674~679 (2009)
- Centers for Disease Control and Prevent ion (CDC), "Hospitalized patients with novel influenza A (H1N1) virus infection - California, April-May, 2009", MMWR Morb Mortal Wkly Rep, 58, pp.536~541 (2009)
- ANZIC Influenza Investigators, "Critical care services and 2009 H1N1 inf luenza in Australia and New Zealand", N Engl J Med, 361, pp.1925~1934 (2009)
- "CDC protocol of realtime RT PCR for influenza A (H1N1). 2009"[URL]
- Chun JK, "Establishing a surveillance network for severe lower respiratory tract infections in Korean infants and young children", Eur J Clin Microbiol Infect Dis, 28, pp.841~844 (2009)
- Choi EH, "The association of newly identified respiratory viruses with lower respiratory tract infections in Korean children, 2000-2005", Clin Infect Dis, 43, pp.585~592 (2006)
- Bharaj P, "Respiratory viral infections detected by multiplex PCR among pediatric patients with lower respiratory tract infections seen at an urban hospital in Delhi from 2005 to 2007", Virol J, 6, pp.89~ (2009)
- Fraser C, "WHO Rapid Pandemic Assessment Collaboration. Pandemic potential of a strain of influenza A (H1N1): early findings", Science, 324, pp.1557~1561 (2009)
- Hospital Inf luenza Workgroup Singapore, "Management of novel inf luenza epidemics in Singapore: consensus recommendations from the Hospital Influenza Workgroup (Singapore)", Singapore Med J, 50, pp.567~580 (2009)
- Nichols JE, "Human lymphocyte apoptosis after exposure to influenza A virus", J Virol, 75, pp.5921~5929 (2001)
- Cunha BA, "Diagnostic importance of relative lymphopenia as a marker of swine influenza (H1N1) in adults", Clin Infect Dis, 49, pp.1454~1456 (2009)
- Cao B, "Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China", N Engl J Med, 361, pp.2507~2517 (2009)
- Crockett GS, "Hypokalaemia in influenza", Br Med J, 2, pp.178~ (1970)
- Kelly KJ, "Fatal rhabdomyolysis following influenza infection in a girl with familial carnitine palmityl transferase deficiency", Pediatrics, 84, pp.312~316 (1989)
- Gomersall CD, "Pro", con clinical debate: steroids are a key component in the treatment of SARS. Pro: Yes, steroids are a key component of the treatment regimen for SARS, 2004, pp.8, 105~107
- Tuvim MJ, "Augmented lung inflammation protects against influenza A pneumonia", PLoS One, 4, pp.e4176~ (2009)