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Diagnosis of Pneumococcal Pneumonia: Current Pitfalls and the Way Forward

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초록

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia. However, it can also asymptomatically colonize the upper respiratory tract. Because of the need to distinguish between S. pneumoniae that is simply colonizingthe upper respiratory tract and S. pneumoniae that is causing pneumonia, accurate diagnosis of pneumococcal pneumonia is a challenging issue that still needs to be solved. Sputum Gram stains and culture are the first diagnostic step for identifying pneumococcal pneumonia and provide information on antibiotic susceptibility. However, these conventional methods are relatively slow and insensitive and show limited specificity. In the past decade, new diagnostic tools have been developed, particularlyantigen (teichoic acid and capsular polysaccharides) and nucleic acid (ply, lytA, and Spn9802) detection assays. Use of the pneumococcal antigen detection methods along with biomarkers (C-reactive protein and procalcitonin) may enhance the specificity of diagnosis for pneumococcal pneumonia. This article provides an overview of current methods of diagnosing pneumococcal pneumonia and discusses new and future test methods that may provide the way forward for improving its diagnosis.

Abstract

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia. However, it can also asymptomaticallycolonize the upper respiratory tract. Because of the need to distinguish between S. pneumoniae that is simply colonizingthe upper respiratory tract and S. pneumoniae that is causing pneumonia, accurate diagnosis of pneumococcal pneumonia is achallenging issue that still needs to be solved. Sputum Gram stains and culture are the first diagnostic step for identifying pneumococcalpneumonia and provide information on antibiotic susceptibility. However, these conventional methods are relativelyslow and insensitive and show limited specificity. In the past decade, new diagnostic tools have been developed, particularlyantigen (teichoic acid and capsular polysacc arides) and nucleic acid (ply, lytA, and Spn9802) detection assays. Use of the pneumococcal antigen detection methods along with biomarkers (C-reactive protein and procalcitonin) may enhance the specificity of diagnosis for pneumococcal pneumonia. This article provides an overview of current methods of diagnosing pneumococcal pneumonia and discusses new and future test methods that may provide the way forward for improving its diagnosis.

참고문헌 (141)

  1. Mandell LA., "Epidemiology and etiology of communityacquired pneumonia", Infect Dis Cl in Nor th Am, 18, pp.761~776 (2004)
  2. Marrie TJ, "Epidemiology of community-acquiredpneumonia in Edmonton, Alberta: an emergencydepartment-based study", Can Respir J, 12, pp.139~142 (2005)
  3. Fine MJ, "Prognosis and outcomes of patientswith community-acquired pneumonia. A metaanalysis", JAMA, 275, pp.134~141 (1996)
  4. Musher DM, "Bacteremic and nonbacteremicpneumococcal pneumonia. A prospectivestudy", Medicine (Baltimore), 79, pp.210~221 (2000)
  5. 정기석, "Economic Burden and Epidemiology of Pneumonia in Korean Adults Aged over 50 Years", Journal of Korean Medical Science, 28(6), pp.888~895 (2013), 대한의학회
  6. Said MA, "AGEDD Adult Pneumococcal Burden Study Team, Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques", PLoS One, 8, pp.e60273~ (2013)
  7. Briles DE, "Protection of the elderly from pneumococcalpneumonia with a protein-based vaccine", Mech AgeingDev, 125, pp.129~131 (2004)
  8. Calix JJ, "A new pneumococcal serotype, 11E,has a variably inactivated wcjE gene", J Infect Dis, 202, pp.29~38 (2010)
  9. Henrichsen J, "Six newly recognized types of Streptococcuspneumoniae", J Clin Microbiol, 33, pp.2759~2762 (1995)
  10. Croucher NJ, "Rapid pneumococcalevolution in response to clinical interventions", Science, 331, pp.430~434 (2011)
  11. 송준영, "Clinical Implications of Pneumococcal Serotypes: Invasive Disease Potential, Clinical Presentations, and Antibiotic Resistance", Journal of Korean Medical Science, 28(1), pp.4~15 (2013), 대한의학회
  12. Hill PC, "Nasopharyngealcarriage of Streptococcus pneumoniae in Gambian villagers", Clin Infect Dis, 43, pp.673~679 (2006)
  13. Werno AM, "Medical microbiology: laboratorydiagnosis of invasive pneumococcal disease", Clin InfectDis, 46, pp.926~932 (2008)
  14. Dyson C, "Infective endocarditis:an epidemiological review of 128 episodes", J Infect, 38, pp.87~93 (1999)
  15. Keith ER, "Characteristicsof Streptococcus pseudopneumoniae isolatedfrom purulent sputum samples", J Clin Microbiol, 44, pp.923~927 (2006)
  16. Dilworth JA, "Methods to improve detection of pneumococci in respiratorysecretions", J Clin Microbiol, 2, pp.453~455 (1975)
  17. Sondag JE, "Detection ofpneumococci in respiratory secretions: clinical evaluationof gentamicin blood agar", J Clin Microbiol, 5, pp.397~400 (1977)
  18. Wu SC, "Comparison of media andculture techniques for detection of Streptococcus pneumoniaein respiratory secretions", J Clin Microbiol, 12, pp.772~775 (1980)
  19. Schmid RE, "Gentamicinbloodagar for isolation of Streptococcus pneumoniaefrom respiratory secretions", J Clin Microbiol, 7, pp.426~427 (1978)
  20. Arbique JC, "Accuracy of phenotypic and genotypic testingfor identification of Streptococcus pneumoniae anddescription of Streptococcus pseudopneumoniae sp. nov", JClin Microbiol, 42, pp.4686~4696 (2004)
  21. Kellogg JA, "Identification of Streptococcus pneumoniae revisited", JClin Microbiol, 39, pp.3373~3375 (2001)
  22. Greve T, "Accuracy of using the lytA gene to distinguishStreptococcus pneumoniae from related species", J Med Microbiol, 61, pp.478~482 (2012)
  23. Suzuki N, "Genotypic identification of presumptive Streptococcuspneumoniae by PCR using four genes highly specificfor S. pneumoniae.", J Med Microbiol, 55, pp.709~714 (2006)
  24. Leegaard TM, "Phenotypic and genomic characterization of pneumococcus-like streptococci isolated from HIV-seropositivepatients", Microbiology, 156, pp.838~848 (2010)
  25. Park IH, "Nontypeable pneumococci can be dividedinto multiple cps types, including one type expressing thenovel gene pspK", MBio, 3 (2012)
  26. Hanage WP, "Using multilocus sequence data todefine the pneumococcus", J Bacteriol, 187, pp.6223~6230 (2005)
  27. Meehan TP, "Quality of care, process, and outcomes in elderly patientswith pneumonia", JAMA, 278, pp.2080~2084 (1997)
  28. Jadavji T, "A practical guide for the diagnosis and treatment ofpediatric pneumonia", CMAJ, 156, pp.S703~S711 (1997)
  29. Cardoso MR, "Adding fever to WHO criteria for diagnosingpneumonia enhances the ability to identify pneumoniacases among wheezing children", Arch Dis Child, 96, pp.58~61 (2011)
  30. Irfan M, "Community-acquired pneumonia", Curr Opin Pulm Med, 19, pp.198~208 (2013)
  31. Mandell LA, "InfectiousDiseases Society of America; American Thoracic Society.Infectious Diseases Society of America", American ThoracicSociety consensus guidelines on the management ofcommunity-acquired pneumonia in adults, 2007, pp.44(2), S27~S72
  32. Anevlavis S, "Community acquired bacterialpneumonia", Expert Opin Pharmacother, 11, pp.361~374 (2010)
  33. Bradley JS, "Pediatric InfectiousDiseases Society and the Infectious Diseases Societyof America. The management of community-acquired pneumonia in infants and children older than 3 months ofage: clinical practice guidelines by the Pediatric InfectiousDiseases Society and the Infectious Diseases Society ofAmerica", Clin Infect Dis, 53, pp.e25~e76 (2011)
  34. Scott JA, "Diagnosis of pneumococcalpneumonia by psaA PCR analysis of lung aspiratesfrom adult patients in Kenya", J Clin Microbiol, 41, pp.2554~2559 (2003)
  35. Bartlett JG, "Community-acquired pneumonia", N Engl J Med, 333, pp.1618~1624 (1995)
  36. Barrett-Connor E, "The nonvalue of sputum culture in thediagnosis of pneumococcal pneumonia", Am Rev RespirDis, 103, pp.845~848 (1971)
  37. Musher DM, "Diagnostic value ofmicroscopic examination of Gram-stained sputum andsputum cultures in patients with bacteremic pneumococcalpneumonia", Clin Infect Dis, 39, pp.165~169 (2004)
  38. Murray PR, "and baceriologicanalysis of expectorated sputum", Mayo Clin Proc, 50, pp.339~344 (1975)
  39. Reed WW, "Sputum Gram’s stain in community-acquired pneumococcalpneumonia. A meta-analysis", West J Med, 165, pp.197~204 (1996)
  40. Anevlavis S, "A prospectivestudy of the diagnostic utility of sputum Gramstain in pneumonia", J Infect, 59, pp.83~89 (2009)
  41. Roson B, "Prospective study of the usefulness of sputum Gramstain in the initial approach to community-acquiredpneumonia requiring hospitalization", Clin Infect Dis, 31, pp.869~874 (2000)
  42. Miyashita N, "Assessment of the usefulnessof sputum Gram stain and culture for diagnosis of community-acquired pneumonia requiring hospitalization", Med Sci Monit, 14, pp.CR171~C176 (2008)
  43. Fine MJ, "Evaluation of housestaff physicians’preparation and interpretation of sputum Gram stains forcommunity-acquired pneumonia", J Gen Intern Med, 6, pp.189~198 (1991)
  44. Fiala M, "A study of the combined role of viruses, mycoplasmasand bacteria in adult pneumonia", Am J Med Sci, 257, pp.44~51 (1969)
  45. Tempest B, "The value of respiratory tract bacteriology in pneumococcalpneumonia among Navajo Indians", Am Rev Respir Dis, 109, pp.577~578 (1974)
  46. Davidson M, "Bacteriologic diagnosisof acute pneumonia. Comparison of sputum, transtrachealaspirates, and lung aspirates", JAM, 235, pp.158~163 (1976)
  47. Drew WL, "Value of sputum culture in diagnosis of pneumococcalpneumonia", J Clin Microbiol, 6, pp.62~65 (1977)
  48. Kalin M, "Bacteremic pneumococcal pneumonia: value ofculture of nasopharyngeal specimens and examination ofwashed sputum specimens", Eur J Clin Microbiol, 1, pp.394~396 (1982)
  49. Guzzetta P, "Rapid diagnosisof community-acquired bacterial pneumonia", AmRev Respir Dis, 128, pp.461~464 (1983)
  50. Perlino CA, "Laboratory diagnosis of pneumonia due toStreptococcus pneumoniae", J Infect Dis, 150, pp.139~144 (1984)
  51. Watanakunakorn C, "Adult bacteremic pneumococcalpneumonia in a community teaching hospital,1992-1996. A detailed analysis of 108 cases", Arch InternMed, 157, pp.1965~1971 (1997)
  52. Torres JM, "Streptococcuspneumoniae bacteremia in a community hospital", Chest, 113, pp.387~390 (1998)
  53. Chalasani NP, "Clinical utility of blood cultures in adult patientswith community-acquired pneumonia without definedunderlying risks", Chest, 108, pp.932~936 (1995)
  54. Fang GD, "New andemerging etiologies for community-acquired pneumoniawith implications for therapy. A prospective multicenterstudy of 359 cases", Medicine (Baltimore), 69, pp.307~316 (1990)
  55. Lieberman D, "Multiplepathogens in adult patients admitted with community-acquired pneumonia: a one year prospective study of346 consecutive patients", Thorax, 51, pp.179~184 (1996)
  56. Luna CM, "Community-acquired pneumonia:etiology, epidemiology, and outcome at a teachinghospital in Argentina", Chest, 118, pp.1344~1354 (2000)
  57. Petti CA, "Streptococcus pneumoniaeantigen test using positive blood culture bottles as analternative method to diagnose pneumococcal bacteremia", J Clin Microbiol, 43, pp.2510~2512 (2005)
  58. Buckingham SC, "Incidence and etiologies of complicated parapneumonic effusions in children,1996 to 2001", Pediatr Infect Dis J, 22, pp.499~504 (2003)
  59. Byington CL, "Impact of the pneumococcal conjugate vaccineon pneumococcal parapneumonic empyema", Pediatr InfectDis J, 25, pp.250~254 (2006)
  60. Gupta R, "Increasing paediatric empyema admissions", Thorax, 61, pp.179~180 (2006)
  61. Langley JM, "Empyema associated with community-acquiredpneumonia: a Pediatric Investigator’s CollaborativeNetwork on Infections in Canada (PICNIC) study", BMC Infect Dis, 8, pp.129~ (2008)
  62. Burgos J, "The increasing incidence ofempyema", Curr Opin Pulm Med, 19, pp.350~356 (2013)
  63. Holmberg H, "Comparison of enzyme-linked immunosorbentassay with coagglutination and latex agglutinationfor rapid diagnosis of pneumococcal pneumoniaby detecting antigen in sputa", Eur J Clin Microbiol, 5, pp.282~286 (1986)
  64. Andreo F, "Persistence of Streptococcuspneumoniae urinary antigen excretion after pneumococcalpneumonia", Eur J Clin Microbiol Infect Dis, 28, pp.197~201 (2009)
  65. Yu J, "Pneumococcalserotypes causing pneumonia with pleural effusion in pediatricpatients", J Clin Microbiol, 49, pp.534~538 (2011)
  66. Bos LD, "Volatile metabolites of pathogens:a systematic review", PLoS Pathog, 9, pp.e1003311~ (2013)
  67. Glover DT, "Streptococcuspneumoniae surface protein PcpA elicits protectionagainst lung infection and fatal sepsis", Infect Immun, 76, pp.2767~2776 (2008)
  68. Johnston JW, "Mn2+-dependent regulation of multiple genes in Streptococcuspneumoniae through PsaR and the resultant impacton virulence", Infect Immun, 74, pp.1171~1180 (2006)
  69. Charkaluk ML, "Assessmentof a rapid urinary antigen detection by an immunochromatographictest for diagnosis of pneumococcal infectionin children", Diagn Microbiol Infect Dis, 55, pp.89~94 (2006)
  70. Dominguez J, "Usefulness of urinary antigen detection by an immunochromatographictest for diagnosis of pneumococcalpneumonia in children", J Clin Microbiol, 41, pp.2161~2163 (2003)
  71. Dowell SF, "Evaluationof Binax NOW, an assay for the detection of pneumococcalantigen in urine samples, performed among pediatricpatients", Clin Infect Dis, 32, pp.824~825 (2001)
  72. Elemraid MA, "on behalf of theNorth East of England Paediatric Respiratory InfectionStudy Group. A case-control study to assess the urinarypneumococcal antigen test in childhood pneumonia", ClinPediatr (Phila) (2013)
  73. Hamann L, "Inhibitionof LPS-induced activation of alveolar macrophagesby high concentrations of LPS-binding protein", BiochemBiophys Res Commun, 295, pp.553~560 (2002)
  74. Strachan RE, "Australian Research Networkin Empyema (ARNiE). A bedside assay to detect Streptococcuspneumoniae in children with empyema", PediatrPulmonol, 46, pp.179~183 (2011)
  75. Porcel JM, "Contribution of apleural antigen assay (Binax NOW) to the diagnosis ofpneumococcal pneumonia", Chest, 131, pp.1442~1447 (2007)
  76. Picazo JJ, "Heracles Study Group. Rapid diagnosisof invasive pneumococcal disease in pediatricpopulation", J Microbiol Methods, 93, pp.116~120 (2013)
  77. Martinon-Torres F, "Pleural antigen assayin the diagnosis of pediatric pneumococcal empyema", J Crit Care, 27, pp.321~ (2012)
  78. Lee JH, "Diagnosis of pneumococcalempyema using immunochromatographic teston pleural fluid and serotype distribution in Korean children", Diagn Microbiol Infect Dis, 72, pp.119~124 (2012)
  79. Casado Flores J, "Usefulness of pneumococcal antigen detection inpleural effusion for the rapid diagnosis of infection byStreptococcus pneumoniae", Eur J Pediatr, 169, pp.581~584 (2010)
  80. Le Monnier A, "Microbiological diagnosis of empyema in children: comparative evaluations byculture, polymerase chain reaction, and pneumococcalantigen detection in pleural fluids", Clin Infect Dis, 42, pp.1135~1140 (2006)
  81. Sinclair A, "Systematic reviewand meta-analysis of a urine-based pneumococcalantigen test for diagnosis of community-acquired pneumoniacaused by Streptococcus pneumoniae", J Clin Microbiol, 51, pp.2303~2310 (2013)
  82. Horita N, "Sensitivity and specificity of theStreptococcus pneumoniae urinary antigen test for unconcentratedurine from adult patients with pneumonia:a meta-analysis", Respirology, 18, pp.1177~1183 (2013)
  83. Boulware DR, "Rapid diagnosis of pneumococcal pneumonia amongHIV-infected adults with urine antigen detection", J Infect, 55, pp.300~309 (2007)
  84. Smith MD, "Rapid diagnosis of bacteremicpneumococcal infections in adults by using the BinaxNOW Streptococcus pneumoniae urinary antigen test: aprospective, controlled clinical evaluation", J Clin Microbiol, 41, pp.2810~2813 (2003)
  85. Roson B, "Contribution of a urinaryantigen assay (Binax NOW) to the early diagnosis of pneumococcalpneumonia", Clin Infect Dis, 38, pp.222~226 (2004)
  86. Murdoch DR, "Evaluation of a rapid immunochromatographictest for detection of Streptococcus pneumoniaeantigen in urine samples from adults with community-acquired pneumonia", J Clin Microbiol, 39, pp.3495~3498 (2001)
  87. Gutierrez F, "Evaluation of theimmunochromatographic Binax NOW assay for detectionof Streptococcus pneumoniae urinary antigen in a prospectivestudy of community-acquired pneumonia inSpain", Clin Infect Dis, 36, pp.286~292 (2003)
  88. Dominguez J, "Detection of Streptococcus pneumoniae antigenby a rapid immunochromatographic assay in urine samples", Chest, 119, pp.243~249 (2001)
  89. Marcos MA, "Rapid urinary antigen test for diagnosis of pneumococcalcommunity-acquired pneumonia in adults", EurRespir J, 21, pp.209~214 (2003)
  90. Navarro D, "Spanish Pneumococcal Infection StudyNetwork. Performance of the Binax NOW Streptococcuspneumoniae urinary antigen assay for diagnosis of pneumoniain children with underlying pulmonary diseases inthe absence of acute pneumococcal infection", J Clin Microbiol, 42, pp.4853~4855 (2004)
  91. Dochez AR, "The elaboration of specific solublesubstance by pneumococcus during growth", J Exp Med, 26, pp.477~493 (1917)
  92. Schaffner A, "Detection ofcapsular polysaccharide in serum for the diagnosis ofpneumococcal pneumonia: clinical and experimentalevaluation", J Infect Dis, 163, pp.1094~1102 (1991)
  93. Bewick T, "Serotype prevalence in adults hospitalisedwith pneumococcal non-invasive community-acquiredpneumonia", Thorax, 67, pp.540~545 (2012)
  94. Pride MW, "Validationof an immunodiagnostic assay for detection of 13Streptococcus pneumoniae serotype-specific polysaccharidesin human urine", Clin Vaccine Immunol, 19, pp.1131~1141 (2012)
  95. Sheppard CL, "Developmentof a sensitive, multiplexed immunoassay usingxMAP beads for detection of serotype-specific Streptococcuspneumoniae antigen in urine samples", J Med Microbiol, 60, pp.49~55 (2011)
  96. Sherwin RL, "Distributionof 13-valent pneumococcal conjugate vaccine Streptococcuspneumoniae serotypes in US adults aged ≥50years with community-acquired pneumonia", J Infect Dis, 208, pp.1813~1820 (2013)
  97. Eastham KM, "Clinical features, aetiology andoutcome of empyema in children in the north east of England", Thorax, 59, pp.522~525 (2004)
  98. Fletcher M, "South Westof England Invasive Community Acquired Infection StudyGroup. Childhood empyema: limited potential impact of7-valent pneumococcal conjugate vaccine", Pediatr InfectDis J, 25, pp.559~560 (2006)
  99. Blaschke AJ, "Interpreting assays for the detection ofStreptococcus pneumoniae", Clin Infect Dis, 52(4), pp.S331~S337 (2011)
  100. Lorente ML, "Diagnosis of pneumococcalpneumonia by polymerase chain reaction (PCR) inwhole blood: a prospective clinical study", Thorax, 55, pp.133~137 (2000)
  101. Rudolph KM, "Evaluationof polymerase chain reaction for diagnosis of pneumococcalpneumonia", J Clin Microbiol, 31, pp.2661~2666 (1993)
  102. Salo P, "Diagnosis of bacteremicpneumococcal pneumonia by amplification of pneumolysingene fragment in serum", J Infect Dis, 171, pp.479~482 (1995)
  103. Sheppard CL, "Diagnosis of invasive pneumococcal infectionby PCR amplification of Streptococcus pneumoniaegenomic fragments in blood: a multi-centre comparativestudy", Commun Dis Public Health, 6, pp.221~227 (2003)
  104. Carvalho Mda G, "Evaluation and improvement of real-timePCR assays targeting lytA, ply, and psaA genes for detectionof pneumococcal DNA", J Clin Microbiol, 45, pp.2460~2466 (2007)
  105. Neeleman C, "Pneumolysin is a key factor in misidentificationof macrolide-resistant Streptococcus pneumoniaeand is a putative virulence factor of S. mitis and otherstreptococci", J Clin Microbiol, 42, pp.4355~4357 (2004)
  106. Abdeldaim G, "Usefulness of real-timePCR for lytA, ply, and Spn9802 on plasma samples forthe diagnosis of pneumococcal pneumonia", Clin MicrobiolInfect, 16, pp.1135~1141 (2010)
  107. Azzari C, "PneumococcalDNA is not detectable in the blood of healthy carrierchildren by real-time PCR targeting the lytA gene", JMed Microbiol, 60, pp.710~714 (2011)
  108. Abdeldaim GM, "Toward a quantitative DNA-based definition ofpneumococcal pneumonia: a comparison of Streptococcuspneumoniae target genes, with special reference tothe Spn9802 fragment", Diagn Microbiol Infect Dis, 60, pp.143~150 (2008)
  109. Vernet G, "Laboratory-based diagnosis of pneumococcal pneumonia:state of the art and unmet needs", Clin Microbiol Infect, 17(3), pp.1~13 (2011)
  110. Carrol ED, "IPD Study Group, WhiteSA, Molyneux EM, Molyneux ME, Smyth RL, Hart CA.High pneumococcal DNA loads are associated with mortalityin Malawian children with invasive pneumococcaldisease", Pediatr Infect Dis J, 26, pp.416~422 (2007)
  111. Pilishvili T, "ActiveBacterial Core Surveillance", Emerging Infections ProgramNetwork. Sustained reductions in invasive pneumococcaldisease in the era of conjugate vaccine, 2010, pp.201, 32~41
  112. Butler JC, "Classicaland latent class analysis evaluation of sputum polymerasechain reaction and urine antigen testing for diagnosisof pneumococcal pneumonia in adults", J Infect Dis, 187, pp.1416~1423 (2003)
  113. Murdoch DR, "Evaluation of a PCR assay for detection ofStreptococcus pneumoniae in respiratory and nonrespiratorysamples from adults with community-acquiredpneumonia", J Clin Microbiol, 41, pp.63~66 (2003)
  114. Paul ML, "Sputum PCR for the detection ofpneumococcal lower respiratory tract infection", Pathology, 29, pp.104~105 (1997)
  115. Wheeler J, "Detection ofpneumolysin in sputum", J Med Microbiol, 48, pp.863~866 (1999)
  116. Albrich WC, "Useof a rapid test of pneumococcal colonization density todiagnose pneumococcal pneumonia", Clin Infect Dis, 54, pp.601~609 (2012)
  117. Tharpe JA, "Comparison of apneumococcal common protein (PsaA) antibody ELISA and a PsaA immune complex ELISA for detection ofpneumococcal serum antibody", Pathobiology, 66, pp.77~83 (1998)
  118. Scott JA, "Validation of immunoglobulinG enzyme-linked immunosorbent assay forantibodies to pneumococcal surface adhesin A in the diagnosisof pneumococcal pneumonia among adults inKenya", J Infect Dis, 186, pp.220~226 (2002)
  119. Scott JA, "Diagnosis of invasivepneumococcal disease among children in Kenyawith enzyme-linked immunosorbent assay for immunoglobulinG antibodies to pneumococcal surface adhesinA", Clin Diagn Lab Immunol, 12, pp.1195~1201 (2005)
  120. Jado I, "Identification of thepsaA gene, coding for pneumococcal surface adhesin A,in viridans group streptococci other than Streptococcuspneumoniae", Clin Diagn Lab Immunol, 8, pp.895~898 (2001)
  121. Song JY, "Pneumococcalvaccine and opsonic pneumococcal antibody", J Infect Chemother, 19, pp.412~425 (2013)
  122. Tuerlinckx D, "Evaluation of a WHO-validated serotypespecificserological assay for the diagnosis of pneumococcaletiology in children with community-acquiredpneumonia", Pediatr Infect Dis J, 32, pp.e277~e284 (2013)
  123. Upadhyay S, "Biomarkers: what is theirbenefit in the identification of infection, severity assessment,and management of community-acquired pneumonia", Infect Dis Clin North Am, 27, pp.19~31 (2013)
  124. Gibot S, "Soluble triggering receptor expressed on myeloidcells and the diagnosis of pneumonia", N Engl J Med, 350, pp.451~458 (2004)
  125. Ruiz-Gonzalez A, "Triggering receptor(TREM-1) expressed on myeloid cells predicts bacteremiabetter than clinical variables in community-acquiredpneumonia", Respirology, 16, pp.321~325 (2011)
  126. Niederman MS, "Biological markers to determine eligibilityin trials for community-acquired pneumonia: a focuson procalcitonin", Clin Infect Dis, 47(3), pp.S127~S132 (2008)
  127. Agrawal A, "AC-reactive protein mutant that does not bind to phosphocholineand pneumococcal C-polysaccharide", J Immunol, 169, pp.3217~3222 (2002)
  128. Madhi SA, "Use ofprocalcitonin and C-reactive protein to evaluate vaccineefficacy against pneumonia", PLoS Med, 2, pp.e38~ (2005)
  129. Madhi SA, "World Health Organisation definitionof “radiologically-confirmed pneumonia” may under-estimate the true public health value of conjugatepneumococcal vaccines", Vaccine, 25, pp.2413~2419 (2007)
  130. Galetto-Lacour A, "Elevated inflammatory markers combinedwith positive pneumococcal urinary antigen are agood predictor of pneumococcal community-acquiredpneumonia in children", Pediatr Infect Dis J, 32, pp.1175~1179 (2013)
  131. Song JY, "Clinical, laboratoryand radiologic characteristics of 2009 pandemic influenzaA", H1N1 pneumonia: primary influenza pneumoniaversus concomitant, InfluenzaOther Respir Viruses, pp.2011, 5[DOI]
  132. Horie M, "Diagnosticand prognostic value of procalcitonin in community-acquired pneumonia", Am J Med Sci, 343, pp.30~35 (2012)
  133. Lacoma A, "Usefulness of consecutive biomarkers measurement inthe management of community-acquired pneumonia", Eur J Clin Microbiol Infect Dis, 31, pp.825~833 (2012)
  134. Klugman KP, "Novel approachesto the identification of Streptococcus pneumoniae as thecause of community-acquired pneumonia", Clin InfectDis, 47(3), pp.S202~S206 (2008)
  135. Penaranda M, "Effectivenessof polysaccharide pneumococcal vaccine inHIV-infected patients: a case-control study", Clin InfectDis, 45, pp.e82~e87 (2007)
  136. Slupsky CM, "Pneumococcal pneumonia: potential for diagnosisthrough a urinary metabolic profile", J ProteomeRes, 8, pp.5550~5558 (2009)
  137. Stevenson LG, "Rapid identificationof bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight massspectrometry", J Clin Microbiol, 48, pp.444~447 (2010)
  138. Risch M, "Comparison of MALDI TOF with conventionalidentification of clinically relevant bacteria", Swiss MedWkly, 140, pp.w13095~ (2010)
  139. Dubois D, "Identification of clinical Streptococcus pneumoniae isolatesamong other alpha and nonhemolytic streptococciby use of the Vitek MS matrix-assisted laser desorptionionization-time of flight mass spectrometrysystem", J Clin Microbiol, 51, pp.1861~1867 (2013)
  140. 박주원, "소아의 세균성 호흡기감염의 진단을 위한 SeeplexTM Pneumobacter Multiplex PCR 키트의 평가", Annals of Laboratory Medicine, 29(4), pp.307~313 (2009), 대한진단검사의학회
  141. Abdeldaim GM, "Multiplex quantitativePCR for detection of lower respiratory tract infectionand meningitis caused by Streptococcus pneumoniae,Haemophilus influenzae and Neisseria meningitidis", BMC Microbiol, 10, pp.310~ (2010)

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