폐렴원인균으로서 약제내성 폐렴사슬알균 (Drug-resistant Streptococcus pneumoniae )의 현황과 임상적 의미
Clinical Implications of Drug-Resistant Streptococcus pneumoniae as a Cause of Community Acquired Pneumonia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The emergence of antibiotic-resistant pathogens is a serious clinical problem in the treatment of infectious diseases that increase mortality, morbidity, hospitalization length, and the cost of healthcare. In particular, Streptococcus pneumoniae is a major etiologic pathogen of pneumonia, sinusitis, otitis media, and meningitis. As the definition of penicillin resistance to S. pneumoniae was recently changed, macrolide-resistant S. pneumoniae is a major resistant pathogen in the community. Infections caused by antibiotic-resistant strains are associated with incorrect use of antibiotics and critical clinical outcomes. For the appropriate use of antibiotics to treat infections, physicians always should have up-to-date information on the current epidemiologic status of antibiotic resistance for common pathogens and their susceptibility to antimicrobials. Appropriate selection of antimicrobials, strict control of infection, vaccination, and development of a feasible national policy of infection control are important strategies for the control of antimicrobial resistance. This review article focuses on the current status of antibiotic-resistant S. pneumoniae in community-acquired pneumonia in Korea.
Abstract
The emergence of antibiotic-resistant pathogens is a serious clinical problem in the treatment of infectious diseases that increase mortality, morbidity, hospitalization length, and the cost of healthcare. In particular, Streptococcus pneumoniae is a major etiologic pathogen of pneumonia, sinusitis, otitis media, and meningitis. As the definition of penicillin resistance to S. pneumoniae was recently changed, macrolide-resistant S. pneumoniae is a major resistant pathogen in the community. Infections caused by antibiotic-resistant strains are associated with incorrect use of antibiotics and critical clinical outcomes. For the appropriate use of antibiotics to treat infections, physicians always should have up-to-date information on the current epidemiologic status of antibiotic resistance for common pathogens and their susceptibility to antimicrobials. Appropriate selection of antimicrobials, strict control of infection, vaccination, and development of a feasible national policy of infection control are important strategies for the control of antimicrobial resistance. This review article focuses on the current status of antibiotic-resistant S. pneumoniae in community-acquired pneumonia in Korea.
참고문헌 (19)
- Lee HJ, "High incidence of resistant to multiple antimicrobials in clinical isolates of Streptococcus pneumoniae from a university hospital in Korea", Clin Infect Dis, 20, pp.826~835 (1995)
- Song JH, "Clinical characteristics of penicillin- resistance Streptococcus pneumoniae (PRSP)", 35th Interscience Conference on Antimicrobial Agents and Chemotherapy, pp.40~ (1995)
- Chong Y, "Capsular types and antimicrobials resistance Streptococcus pneumoniae isolated in Korea", Eur J Clin Microbiol Infect Dis, 14, pp.528~531 (1995)
- National Committee for Clinical Laboratory Standards, "Performance standards for antimicrobial susceptibility testing, Fifth informational supplement, M100-55", National Committee for Clinical Laboratory Standards, ~ (1994)
- Janoir C, "High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutation in parC and gyrA", Antimicrob Agents Chemother, 40, pp.2760~2764 (1996)
- Song JH, "Spread of drug- resistant Streptococcus pneumoniae in Asian countries: Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study", Clin Infect Dis, 28, pp.1206~1211 (1999)
- 정숙인, "아시아 지역 폐렴 구균의 항균제 내성 현황 및 변화 양상", Infection and Chemotherapy, 36(1), pp.1~10 (2004), 대한감염학회
- Woo JH, "A prospective multicenter study of community-acquired pneumonia in adults with emphasis on bacterial etiology", Korean J Infect Dis, 33, pp.1~7 (2001)
- 홍지현, "폐렴구균에 의한 지역사회 획득 폐렴에서 페니실린 내성률과 내성에 따른 임상경과에 관한 연구", Tuberculosis and Respiratory Diseases, 54(3), pp.295~303 (2003), 대한결핵및호흡기학회
- Chen DK, "Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. Canadian Bacterial Surveillance Network", N Engl J Med, 341, pp.233~239 (1999)
- Song JH, "High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)", Antimicrob Agents Chemother, 48, pp.2101~2107 (2004)
- Pallares R, "Resistance to penicillin and cephalosporin and mortality from severe pneumococcal pneumonia in Barcelona, Spain", N Engl J Med, 333, pp.474~480 (1995)
- Plouffe JF, "Bacteremia with Streptococcus pneumoniae. Implications for therapy and prevention. Franklin County Pneumonia Study Grou- Pseudomonas", JAMA, 275, pp.194~198 (1996)
- Cheong HJ, "Clinical and genetic characteristics of infection by penicillin- resistant Streptococcus pneumonia from community and hospital", Korean J Infect Dis, 33, pp.112~122 (2001)
- Hwangbo B, "Clinical characteristics of pneumococcal bacteremia in adults: The effect of penicillin resistance on the mortality of patients with pneumococcal bacteremia", Tuberc Respir Dis, 47, pp.184~194 (1999)
- Turett GS, "Penicillin resistance and other predictors of mortality in pneumococcal bacteremia in a population with high human immunodeficiency virus seroprevalence", Clin Infect Dis, 29, pp.321~327 (1999)
- Feikin DR, "Mortality from invasive pneumococcal pneumonia in the era of antibiotic resistance, 1995-1997", Am J Public Health, 90, pp.223~229 (2000)
- Harwell JI, "The drug-resistant pneumococcus: clinical relevance, therapy, and prevention", Chest, 117, pp.530~541 (2000)
- Song JH, "Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)", J Antimicrob Chemother, 53, pp.457~463 (2004)