Establishment of Experimental Murine Peritonitis Model with Hog Gastric Mucin for Carbapenem-Resistant Gram-Negative Bacteria
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Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensivelyreported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored accordingto the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally withdifferent strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicablefor investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonasaeruginosa, and Acinetobacter baumannii) detected in Korea.
Abstract
Animal models are essential to studies of infectious diseases. The use of mice to test bacterial infection has been extensivelyreported. However, methods applied to clinical isolates, particularly for carbapenem-resistant bacteria, must be tailored accordingto the infection models and bacteria used. In this study, we infected 6-week-old female BALB/c mice intraperitoneally withdifferent strains of resistant bacteria plus 3% hog gastric mucin. This method was found to be efficient and readily applicablefor investigation of carbapenem-resisant Gram-negative pathogens (e.g., Escherichia coli, Klebsiella pneumoniae, Pseudomonasaeruginosa, and Acinetobacter baumannii) detected in Korea.
참고문헌 (19)
- "Global action plan on antimicrobial resistance"[URL]
- 이창섭, "Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens", Infection and Chemotherapy, 46(3), pp.149~164 (2014), 대한감염학회
- van Duin D, "Carbapenem- resistant Enterobacteriaceae: a review of treatment and outcomes", Diagn Microbiol Infect Dis, 75, pp.115~120 (2013)
- 이효진, "Carbapenem-resistant Enterobacteriaceae: Prevalence and Risk Factors in a Single Community-Based Hospital in Korea", Infection and Chemotherapy, 48(3), pp.166~173 (2016), 대한감염학회
- Pan CY, "Piscidin is highly active against carbapenem-resistant Acinetobacter baumannii and NDM-1-producing Klebsiella pneumoniae in a systemic septicaemia infection mouse model", Mar Drugs, 13, pp.2287~2305 (2015)
- Cao F, "Evaluation of the efficacy of a bacteriophage in the treatment of pneumonia induced by multidrug resistance Klebsiella pneumoniae in mice", Biomed Res Int, 2015, pp.752930~ (2015)
- Aoki N, "Efficacy of colistin combination therapy in a mouse model of pneumonia caused by multidrug-resistant Pseudomonas aeruginosa", J Antimicrob Chemother, 63, pp.534~542 (2009)
- Pan CY, "Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis", Antimicrob Agents Chemother, 58, pp.4264~4274 (2014)
- Harris G, "A mouse model of Acinetobacter baumannii– associated pneumonia using a clinically isolated hypervirulent strain", Antimicrob Agents Chemother, 57, pp.3601~3613 (2013)
- Rosen DA, "Klebsiella pneumoniae FimK promotes virulence in murine pneumonia", J Infect Dis, 213, pp.649~658 (2016)
- He S, "In vitro and in vivo analysis of antimicrobial agents alone and in combination against multi-drug resistant Acinetobacter baumannii", Front Microbiol, 6, pp.507~ (2015)
- Luo G, "Diabetic murine models for Acinetobacter baumannii infection", J Antimicrob Chemother, 67, pp.1439~1445 (2012)
- Performance standards for antimicrobial susceptibility testing: Twenty-fifth informational supplement M100-S25, "Clinical and Laboratory Standards Institute (CLSI)", CLSI, ~ (2015)
- Kim SH, "Pilot screening to determine antimicrobial synergies in a multidrug-resistant bacterial strain library", Microb Drug Resist, 22, pp.372~378 (2016)
- "Commonoly used mouse strains"[URL]
- Olitzki L., "Mucin as a resistance-lowering substance", Bacteriol Rev, 12, pp.149~172 (1948)
- Dewitt CW, "Differential effect of hog gastric mucin on properdin and host resistance to infection", J Bacteriol, 76, pp.631~639 (1958)
- Rodriguez CA, "An optimized mouse thigh infection model for enterococci and its impact on antimicrobial phamacodynamics", Antimicrob Angents Chemother, 59, pp.233~238 (2015)
- Fattom AI, "A Staphylococcus aureus capsular polysaccharide (CP) vaccine and CP-specific antibodies protect mice against bacterial challenge", Infect Immun, 64, pp.1659~1665 (1996)