Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study
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초록
Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43–17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.
Abstract
Background: Despite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea. Materials and Methods: A cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013. Results: Among the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43–17.13). Conclusion: HBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.
참고문헌 (25)
- Buchacz K, "HOPS Investigators. AIDS-defining opportunistic illnesses in US patients, 1994-2007: a cohort study", AIDS, 24, pp.1549~1559 (2010)
- Schwarcz L, "Declining incidence of AIDS-defining opportunistic illnesses: results from 16 years of population-based AIDS surveillance", AIDS, 27, pp.597~605 (2013)
- 김민정, "Trend of CD4+ Cell Counts at Diagnosis and Initiation of Highly Active Antiretroviral Therapy (HAART): Korea HIV", AIDS Cohort Study, 1992-2015, 2017, pp.49(2), 101~108[DOI]
- Alter MJ, "Epidemiology of viral hepatitis and HIV co-infection", J Hepatol, 44(1 Suppl), pp.S6~S9 (2006)
- Bica I, "Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection", Clin Infect Dis, 32, pp.492~497 (2001)
- Hoffmann CJ, "Clinical implications of HIV and hepatitis B co-infection in Asia and Africa", Lancet Infect Dis, 7, pp.402~409 (2007)
- Nikolopoulos GK, "Impact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: a cohort study and meta-analysis", Clin Infect Dis, 48, pp.1763~1771 (2009)
- Sánchez-Quijano A, "Influence of human immunodeficiency virus type 1 infection on the natural course of chronic parenterally acquired hepatitis C", Eur J Clin Microbiol Infect Dis, 14, pp.949~953 (1995)
- Soto B, "Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis", J Hepatol, 26, pp.1~5 (1997)
- Rockstroh JK, "Influence of viral hepatitis on HIV infection", J Hepatol, 44(1 Suppl), pp.S25~S27 (2006)
- 이선희, "Trends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011", Journal of Korean Medical Science, 28(1), pp.67~73 (2013), 대한의학회
- 이신원, "Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus (HIV) patients in a large HIV clinic in South Korea", The Korean Journal of Internal Medicine, 31(4), pp.772~778 (2016), 대한내과학회[DOI]
- Adekunle AE, "Baseline CD4+ T lymphocyte cell counts, hepatitis B and C viruses seropositivity in adults with Human Immunodeficiency Virus infection at a tertiary hospital in Nigeria", Pan Afr Med J, 9, pp.6~ (2011)
- Koziel MJ, "Viral hepatitis in HIV infection", N Engl J Med, 356, pp.1445~1454 (2007)
- Kellerman SE, "Prevalence of chronic hepatitis B and incidence of acute hepatitis B infection in human immunodeficiency virus- infected subjects", J Infect Dis, 188, pp.571~577 (2003)
- Sungkanuparph S, "Prevalence of hepatitis B virus and hepatitis C virus co-infection with human immunodeficiency virus in Thai patients: a tertiary-care-based study", J Med Assoc Thai, 87, pp.1349~1354 (2004)
- "Korea health statistics 2013: Korea National Health and Nutrition Examination Survey (KNHANES VI- 1)"[URL]
- Kim DY, "A nationwide seroepidemiology of hepatitis C virus infection in South Korea", Liver Int, 33, pp.586~594 (2013)
- Kourtis AP, "HIV-HBV coinfection-- a global challenge", N Engl J Med, 366, pp.1749~1752 (2012)
- Amin J, "HIV and hepatitis C coinfection within the CAESAR study", HIV Med, 5, pp.174~179 (2004)
- Barth RE, "Hepatitis B", C and HIV in sub-Saharan Africa: an association between highly prevalent infectious diseases. A systematic review and meta-analysis, 2010, pp.14, e1024~e1031
- Moreira M, "Characteristics of co-infections by HCV and HBV among Brazilian patients infected by HIV-1 and", or HTLV-1, 2013, pp.17, 661~666
- Chen X, "Prevalence of hepatitis B virus and hepatitis C virus in patients with human immunodeficiency virus infection in Central China", Arch Virol, 158, pp.1889~1894 (2013)
- Platt L, "Prevalence and burden of HCV co-infection in people living with HIV: a global systematic review and meta-analysis", Lancet Infect Dis, 16, pp.797~808 (2016)
- Rao VB, "Hepatitis C seroprevalence and HIV co-infection in sub-Saharan Africa: a systematic review and meta-analysis", Lancet Infect Dis, 15, pp.819~824 (2015)