Coxsackievirus A6-induced Hand-Foot-and-Mouth Disease Mimicking Stevens-Johnson Syndrome in an Immunocompetent Adult
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Hand-foot-and-mouth disease, a highly contagious viral infection, occurs more common in children than in adults. However, there was a recent outbreak of Coxsackievirus A6-induced infection with an atypical presentation among the adult population. Stevens–Johnson syndrome is a severe mucocutaneous disease characterized by extensive necrosis and detachment of the epidermis, and this condition is commonly caused by medications. Herein, we describe a 30-year-old male patient taking allopurinol for the management of gout. The patient presented with numerous erythematous papules, vesicles, and patches with mucosal eruptions on the whole body, oral mucositis, and fever, and he was finally diagnosed with hand-foot-and-mouth disease.
Abstract
Hand-foot-and-mouth disease, a highly contagious viral infection, occurs more common in children than in adults. However, there was a recent outbreak of Coxsackievirus A6-induced infection with an atypical presentation among the adult population. Stevens–Johnson syndrome is a severe mucocutaneous disease characterized by extensive necrosis and detachment of the epidermis, and this condition is commonly caused by medications. Herein, we describe a 30-year-old male patient taking allopurinol for the management of gout. The patient presented with numerous erythematous papules, vesicles, and patches with mucosal eruptions on the whole body, oral mucositis, and fever, and he was finally diagnosed with hand-foot-and-mouth disease.
참고문헌 (20)
- Wong SS, "Human enterovirus 71 and hand, foot and mouth disease", Epidemiol Infect, 138, pp.1071~1089 (2010)
- Laga AC, "Atypical hand, foot and mouth disease in adults associated with coxsackievirus A6 : a clinico-pathologic study", J Cutan Pathol, 43, pp.940~945 (2016)
- Merzel Šabović EK, "Atypical hand, foot, and mouth disease in an adult patient : a case report and literature review", Acta Dermatovenerol Alp Pannonica Adriat, 28, pp.85~88 (2019)
- Osterback R, "Coxsackievirus A6 and hand, foot, and mouth disease, Finland", Emerg Infect Dis, 15, pp.1485~1488 (2009)
- Horsten HH, "Atypical hand, foot, and mouth disease caused by Coxsackievirus A6 in Denmark : a diagnostic mimicker", Acta Derm Venereol, 98, pp.350~354 (2018)
- Stern RS, "Stevens-Johnson syndrome and toxic epidermal necrolysis : associations, outcomes, and pathobiology-thirty years of progress but still much to be done", J Invest Dermatol, 137, pp.1004~1008 (2017)
- Schneider JA, "Stevens-Johnson syndrome and toxic epidermal necrolysis : a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures", Adv Ther, 34, pp.1235~1244 (2017)
- Mockenhaupt M, "Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study", J Invest Dermatol, 128, pp.35~44 (2008)
- Galen WK, "Mucocutaneous manifestations of viral diseases", pp.455~467 (2002), Marcel Dekker
- Feder HM Jr, "Atypical hand, foot, and mouth disease : a vesiculobullous eruption caused by Coxsackie virus A6", Lancet Infect Dis, 14, pp.83~86 (2014)
- Huff JC, "Erythema multiforme : a critical review of characteristics, diagnostic criteria, and causes", J Am Acad Dermatol, 8, pp.763~775 (1983)
- 강진한, "Febrile Illness with Skin Rashes", Infection and Chemotherapy, 47(3), pp.155~166 (2015), 대한감염학회
- Terkeltaub R, "Gout. Novel therapies for treatment of gout and hyperuricemia", Arthritis Res Ther, 11, pp.236~ (2009)
- Kim SC, "Severe cutaneous reactions requiring hospitalization in allopurinol initiators: a population-based cohort study", Arthritis Care Res (Hoboken), 65, pp.578~584 (2013)
- Hung SI, "HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol", Proc Natl Acad Sci U S A, 102, pp.4134~4139 (2005)
- Kimmis BD, "Hand-foot-and-mouth disease caused by coxsackievirus A6 on the rise", Cutis, 102, pp.353~356 (2018)
- Böer-Auer A, "Histopathology of hand-foot-mouth disease in adults and criteria for differentiation from erythema multiforme", Am J Dermatopathol, 41, pp.273~280 (2019)
- Roujeau JC, "Toxic epidermal necrolysis(Lyell syndrome)", J Am Acad Dermatol, 23, pp.1039~1058 (1990)
- Revuz J, "Toxic epidermal necrolysis. Clinical findings and prognosis factors in 87 patients", Arch Dermatol, 123, pp.1160~1165 (1987)
- 신정우, "A Case of Hand-foot-mouth Disease in an Immunocompetent Adult", Annals of Dermatology, 22(2), pp.216~218 (2010), 대한피부과학회
