Enterovirus 71 감염이 동반된 독성표피괴사용해 1례
Isolation of Enterovirus Type 71 in a 3-year-old BoySuffering from Toxic Epidermal Necrolysis
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Toxic epidermal necrolysis (TEN) is an exfoliative disease of skin and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. Enterovirus 71 (EV 71), the most recently described serotype of the genus Enterovirus (family Picornaviridae), causes a variety of diseases, including aseptic meningitis, encephalitis, poliomyelitis-like paralysis, hand-foot-mouth disease, gastroenteritis, fever and rash. A 3-year-old boy presented at the Department of Pediatrics, Soonchunhyang University Cheonan Hospital due to TEN. There were no definite causes such as drug toxicity, Graft-Versus-Host disease (GVHD) and infection. However, we could have isolated EV 71 from the patient's stool. Until now, there have been no reports showing the relationship between EV 71 and TEN, we report here in a case of TEN-associated with EV 71. Further evaluation is needed to study the relationship of TEN with EV 71.
Abstract
Toxic epidermal necrolysis (TEN) is an exfoliative disease of skin and characterized by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. Enterovirus 71 (EV 71), the most recently described serotype of the genus Enterovirus (family Picornaviridae), causes a variety of diseases, including aseptic meningitis, encephalitis, poliomyelitis-like paralysis, hand-foot-mouth disease, gastroenteritis, fever and rash. A 3-year-old boy presented at the Department of Pediatrics, Soonchunhyang University Cheonan Hospital due to TEN. There were no definite causes such as drug toxicity, Graft-Versus-Host disease (GVHD) and infection. However, we could have isolated EV 71 from the patient's stool. Until now, there have been no reports showing the relationship between EV 71 and TEN, we report here in a case of TEN-associated with EV 71. Further evaluation is needed to study the relationship of TEN with EV 71.
참고문헌 (10)
- Joseph GM, "Vesiculobullous disorders. In: Nelson Textbook of Pediatrics", pp.2685~2693 (2007), Philadelphia:Saunders
- Fritsch PO, "Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. In: Dermatology in general medicine", pp.543~557 (2004), New York: McGraw-hill
- Wang JR, "II.Laboratory diagnosis and genetic analysis.J Clin Virol 2000;17:91-9", J Clin Virol, 17, pp.91~99 (2000)
- Brown BA, "Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998", J Virol, 73, pp.9969~9975 (1999)
- 황희승, "Enterovirus 71에 의한 급성 파종성 뇌척수염 1례", 소아감염, 10(1), pp.114~122 (2003), 한국소아감염병학회
- Smith LH, "Toxic epidermal necrolysis", Clin J Oncol Nurs, 11, pp.333~336 (2007)
- Auquier-Dunant A, "SCAR Study Group. Severe Cutaneous Adverse Reactions. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study", Arch Dermatol, 138, pp.1019~1024 (2002)
- Komatsu H, "Outbreak of severe neurologic involvement associated with enterovirus 71 infection", Pediatr Neurol, 20, pp.17~23 (1999)
- McMinn P, "Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia", J Virol, 75, pp.7732~7738 (2001)
- Chung PW, "Duration of enterovirus shedding in stool", J Microbiol Immunol Infect, 34, pp.167~170 (2001)