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Summary of 2021 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-infected Koreans

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초록

Since the establishment of the Committee for Clinical Guidelines for the Diagnosis and Treatment of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) by the Korean Society for AIDS in 2010, clinical guidelines have been prepared in 2011, 2013, 2015, and 2018. As new research findings on the epidemiology, diagnosis, and treatment of AIDS have been published in and outside of Korea along with the development and introduction of new antiretroviral medications, a need has arisen to revise the clinical guidelines by analyzing such new data. The clinical guidelines address the initial evaluation of patients diagnosed with HIV/AIDS, follow-up tests, appropriate timing of medication, appropriate antiretroviral medications, treatment strategies for patients who have concurrent infections with hepatitis B or C virus, recommendations for resistance testing, treatment for patients with HIV and tuberculosis coinfections, and treatment in pregnant women. Through these clinical guidelines, the Korean Society for AIDS and the Committee for Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS contributes to overcoming AIDS by delivering latest data and treatment strategies to healthcare professionals who treat AIDS in the clinic.

Abstract

Since the establishment of the Committee for Clinical Guidelines for the Diagnosis and Treatment of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) by the Korean Society for AIDS in 2010, clinical guidelines have been prepared in 2011, 2013, 2015, and 2018. As new research findings on the epidemiology, diagnosis, and treatment of AIDS have been published in and outside of Korea along with the development and introduction of new antiretroviral medications, a need has arisen to revise the clinical guidelines by analyzing such new data. The clinical guidelines address the initial evaluation of patients diagnosed with HIV/AIDS, follow-up tests, appropriate timing of medication, appropriate antiretroviral medications, treatment strategies for patients who have concurrent infections with hepatitis B or C virus, recommendations for resistance testing, treatment for patients with HIV and tuberculosis coinfections, and treatment in pregnant women. Through these clinical guidelines, the Korean Society for AIDS and the Committee for Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS contributes to overcoming AIDS by delivering latest data and treatment strategies to healthcare professionals who treat AIDS in the clinic.

참고문헌 (90)

  1. The Korean Society for AIDS, "The 2018 Clinical Guidelines for the Diagnosis and Treatment of HIV", AIDS in HIV-Infected Koreans, 2019, pp.51(1), 77~88[DOI]
  2. "Guidelines for the use of antiretroviral agents in adults and adolescents living with HIV"[URL]
  3. Mellors JW, "Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1infection", Ann Intern Med, 126, pp.946~954 (1997)
  4. "European AIDS Clinical Society (EACS) Guidelines for the management of people living with HIV (PLWH) in Europe"[URL]
  5. Freedberg KA, "Initial assessment of patients infected with human immunodeficiency virus: the yield and cost of laboratory testing", J Acquir Immune Defic Syndr, 7, pp.1134~1140 (1994)
  6. "uidelines for the prevention and treatment of opportunistic infections in adults and adolescents with HIV"[URL]
  7. Brogly SB, "Reproductive health of adolescent girls perinatally infected with HIV", Am J Public Health, 97, pp.1047~1052 (2007)
  8. "Recommendations for HIV prevention with adults and adolescents with HIV in the United States, 2014"[URL]
  9. Girard PM, "Can we stop CD4+ testing in patients with HIV-1 RNA suppression on antiretroviral treatment?", AIDS, 27, pp.2759~2763 (2013)
  10. Anonymous, "Human immunodeficiency virus type 1 RNA level and CD4 count as prognostic markers and surrogate end points: a meta-analysis", AIDS Res Hum Retroviruses, 16, pp.1123~1133 (2000)
  11. Lucas GM, "Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America", Clin Infect Dis, 59, pp.e96~e138 (2014)
  12. Aberg JA, "Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of America", Clin Infect Dis, 49, pp.651~681 (2009)
  13. Kaplan JE, "Guidelines for preventing opportunistic infections among HIV-infected persons--2002. Recommendations of the U.S. Public Health Service and the Infectious Diseases Society of America", MMWR Recomm Rep, 51, pp.1~52 (2002)
  14. Hogg RS, "Rates of disease progression by baseline CD4 cell count and viral load after initiating triple-drug therapy", JAMA, 286, pp.2568~2577 (2001)
  15. Mocroft A, "Changing patterns of mortality across Europe in patients infected with HIV-1. EuroSIDA Study Group", Lancet, 352, pp.1725~1730 (1998)
  16. Palella FJ Jr, "Survival benefit of initiating antiretroviral therapy in HIV-infected persons in different CD4+ cell strata", Ann Intern Med, 138, pp.620~626 (2003)
  17. When To Start Consortium. Sterne JA, "Timing of initiation of antiretroviral therapy in AIDSfree HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies", Lancet, 373, pp.1352~1363 (2009)
  18. Strategies for Management of Antiretroviral Therapy (SMART) Study Group, "Major clinical outcomes in antiretroviral therapy (ART)-naive participants and in those not receiving ART at baseline in the SMART study", J Infect Dis, 197, pp.1133~1144 (2008)
  19. Cohen MS, "Prevention of HIV-1 infection with early antiretroviral therapy", N Engl J Med, 365, pp.493~505 (2011)
  20. Labhardt ND, "Effect of offering same-day ART vs usual health facility referral during home-based HIV testing on linkage to care and viral suppression among adults with HIV in Lesotho: The CASCADE randomized clinical trial", JAMA, 319, pp.1103~1112 (2018)
  21. Coffey S, "RAPID antiretroviral therapy: high virologic suppression rates with immediate antiretroviral therapy initiation in a vulnerable urban clinic population", AIDS, 33, pp.825~832 (2019)
  22. Török ME, "Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)--associated tuberculous meningitis", Clin Infect Dis, 52, pp.1374~1383 (2011)
  23. Boulware DR, "Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis", N Engl J Med, 370, pp.2487~2498 (2014)
  24. Molina JM, "Once-daily dolutegravir is superior to once-daily darunavir", ritonavir in treatment-naïve HIV-1-positive individuals: 96 week results from FLAMINGO, 2014, pp.17(4 Suppl 3), 19490~
  25. Raffi F, "Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial", Lancet Infect Dis, 13, pp.927~935 (2013)
  26. Gallant J, "Bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1infection (GS-US-380-1489): a double-blind, multicentre, phase 3, randomised controlled non-inferiority trial", Lancet, 390, pp.2063~2072 (2017)
  27. Stellbrink HJ, "Co-formulated bictegravir, emtricitabine, and tenofovir alafenamide versus dolutegravir with emtricitabine and tenofovir alafenamide for initial treatment of HIV1 infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial", Lancet HIV, 6, pp.e364~e372 (2019)
  28. Wohl DA, "Bictegravir combined with emtricitabine and tenofovir alafenamide versus dolutegravir, abacavir, and lamivudine for initial treatment of HIV-1infection: week 96 results from a randomised, double-blind, multicentre, phase 3, non-inferiority trial", Lancet HIV, 6, pp.e355~e363 (2019)
  29. Rockstroh JK, "Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir", emtricitabine in treatment-naive HIV1-infected patients: final 5-year results from STARTMRK, 2013, pp.63, 77~85
  30. Cahn P, "Raltegravir 1200 mgonce daily vs 400 mg twice daily, with emtricitabine and tenofovir disoproxil fumarate, for previously untreated HIV-1 infection: Week 96 results from ONCEMRK, a randomized, double-blind, noninferiority trial", J Acquir Immune Defic Syndr, 78, pp.589~598 (2018)
  31. Cahn P, "Durable efficacy of dolutegravir plus lamivudine in antiretroviral treatment-naive adults with HIV-1 infection: 96-week results from the GEMINI-1 and GEMINI-2 randomized clinical trials", J Acquir Immune Defic Syndr, 83, pp.310~318 (2020)
  32. Orkin C, "Final 192-week efficacy and safety of once-daily darunavir", ritonavir compared with lopinavir, HIV Med, pp.2013, 14[DOI]
  33. Orkin C, "Week 96 results of a phase 3 trial of darunavir", cobicistat, tenofovir alafenamide in treatment-naive HIV-1 patients, pp.AIDS, 2020[DOI]
  34. Wohl DA, "A randomized, double-blind comparison of single-tablet regimen elvitegravir", cobicistat, tenofovir DF versus single-tablet regimen efavirenz, pp.emtricitabine, tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144results[DOI]
  35. Clumeck N, "A randomized, double-blind comparison of singletablet regimen elvitegravir", cobicistat, tenofovir DF vs ritonavir-boosted atazanavir plus emtricitabine, pp.tenofovir DF for initial treatment of HIV-1 infection: analysis of week 144 results, J Acquir Immune Defic Syndr[DOI]
  36. Molina JM, "Once-daily atazanavir", ritonavir compared with twice-daily lopinavir, J Acquir Immune Defic Syndr, pp.2010, 53[DOI]
  37. Gallant JE, "Cobicistat versus ritonavir as a pharmacoenhancer of atazanavir plus emtricitabine", tenofovir disoproxil fumarate in treatment-naive HIV type 1-infected patients: week 48 results, 2013, pp.208, 32~39
  38. Molina JM, "Once-daily dolutegravir versus darunavir plus ritonavir for treatmentnaive adults with HIV-1 infection (FLAMINGO): 96 week results from a randomised, open-label, phase 3b study", Lancet HIV, 2, pp.e127~e136 (2015)
  39. Daar ES, "Atazanavir plus ritonavir or efavirenz as part of a 3-drug regimen for initial treatment of HIV-1", Ann Intern Med, 154, pp.445~456 (2011)
  40. van Lunzen J, "Rilpivirine vs. efavirenz-based single-tablet regimens in treatment-naive adults: week 96 efficacy and safety from a randomized phase 3b study", AIDS, 30, pp.251~259 (2016)
  41. Palella FJ Jr, "The association of HIV susceptibility testing with survival among HIVinfected patients receiving antiretroviral therapy: a cohort study", Ann Intern Med, 151, pp.73~84 (2009)
  42. Cahn P, "Dolutegravir versus raltegravir in antiretroviral-experienced, integrase-inhibitor-naive adults with HIV: week 48 results from the randomised, double-blind, non-inferiority SAILING study", Lancet, 382, pp.700~708 (2013)
  43. Eron JJ, "Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: final results of two randomised, placebo-controlled trials", Lancet Infect Dis, 13, pp.587~596 (2013)
  44. Lawrence J, "Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virus", N Engl J Med, 349, pp.837~846 (2003)
  45. Deeks SG, "Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia", N Engl J Med, 344, pp.472~480 (2001)
  46. Ledergerber B, "Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes", Lancet, 364, pp.51~62 (2004)
  47. Dinoso JB, "Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy", Proc Natl Acad Sci U S A, 106, pp.9403~9408 (2009)
  48. INSIGHT-ESPRIT Study Group, "Interleukin-2 therapy in patients with HIV infection", N Engl J Med, 361, pp.1548~1559 (2009)
  49. Peters MG, "Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127", Hepatology, 44, pp.1110~1116 (2006)
  50. de Vries-Sluijs TE, "Long-term therapy with tenofovir is effective for patients co-infected with human immunodeficiency virus and hepatitis B virus", Gastroenterology, 139, pp.1934~1941 (2010)
  51. Matthews GV, "Combination HBV therapy is linked to greater HBV DNA suppression in a cohort of lamivudine-experienced HIV", HBV coinfected individuals, 2009, pp.23, 1707~1715
  52. McMahon MA, "The HBV drug entecavir - effects on HIV-1 replication and resistance", N Engl J Med, 356, pp.2614~2621 (2007)
  53. Dore GJ, "Frequent hepatitis B virus rebound among HIVhepatitis B virus-coinfected patients following antiretroviral therapy interruption", AIDS, 24, pp.857~865 (2010)
  54. Macías J, "Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus", hepatitis C virus, 2009, pp.50, 1056~1063
  55. Ragni MV, "Highly active antiretroviral therapy improves ESLD-free survival in HIV-HCV co-infection", Haemophilia, 15, pp.552~558 (2009)
  56. Bersoff-Matcha SJ, "Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus: a review of cases reported to the U.S. Food and Drug Administration adverse event reporting system", Ann Intern Med, 166, pp.792~798 (2017)
  57. Wang C, "Hepatitis due to Reactivation of Hepatitis B Virus in Endemic Areas Among Patients With Hepatitis C Treated With Direct-acting Antiviral Agents", Clin Gastroenterol Hepatol, 15, pp.132~1326.F (2017)
  58. Blanc FX, "Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis", N Engl J Med, 365, pp.1471~1481 (2011)
  59. Havlir DV, "Timing of antiretroviral therapy for HIV-1infection and tuberculosis", N Engl J Med, 365, pp.1482~1491 (2011)
  60. Abdool Karim SS, "Integration of antiretroviral therapy with tuberculosis treatment", N Engl J Med, 365, pp.1492~1501 (2011)
  61. Mfinanga SG, "Early versus delayed initiation of highly active antiretroviral therapy for HIV-positive adults with newly diagnosed pulmonary tuberculosis (TB-HAART): a prospective, international, randomised, placebocontrolled trial", Lancet Infect Dis, 14, pp.563~571 (2014)
  62. Little SJ, "Antiretroviral-drug resistance among patients recently infected with HIV", N Engl J Med, 347, pp.385~394 (2002)
  63. Borroto-Esoda K, "Baseline genotype as a predictor of virological failure to emtricitabine or stavudine in combination with didanosine and efavirenz", AIDS Res Hum Retroviruses, 23, pp.988~995 (2007)
  64. Pozniak AL, "Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine", lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis, 2006, pp.43, 535~540
  65. Kuritzkes DR, "Preexisting resistance to nonnucleoside reversetranscriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects", J Infect Dis, 197, pp.867~870 (2008)
  66. Smith DM, "HIV drug resistance acquired through superinfection", AIDS, 19, pp.1251~1256 (2005)
  67. Verhofstede C, "Interruption of reverse transcriptase inhibitors or a switch from reverse transcriptase to protease inhibitors resulted in a fast reappearance of virus strains with a reverse transcriptase inhibitor-sensitive genotype", AIDS, 13, pp.2541~2546 (1999)
  68. Miller V, "Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure", AIDS, 14, pp.2857~2867 (2000)
  69. Devereux HL, "Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy", AIDS, 13, pp.F123~F127 (1999)
  70. Anonymous, "ACOG committee opinion no. 762: Prepregnancy counseling", Obstet Gynecol, 133, pp.e78~e89 (2019)
  71. Salters K, "Pregnancy incidence and intention after HIV diagnosis among women living with HIV in Canada", PLoS One, 12, pp.e0180524~ (2017)
  72. Aebi-Popp K, "Neglect of attention to reproductive health in women with HIV infection: contraceptive use and unintended pregnancies in the Swiss HIV Cohort Study", HIV Med, 19, pp.339~346 (2018)
  73. Rodger AJ, "Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIVpositive partner is using suppressive antiretroviral therapy", JAMA, 316, pp.171~181 (2016)
  74. Del Romero J, "Natural conception in HIV-serodiscordant couples with the infected partner in suppressive antiretroviral therapy: A prospective cohort study", Medicine (Baltimore), 95, pp.e4398~ (2016)
  75. Pilotto JH, "Maternal outcomes after HAART for the prevention of mother-to-child transmission in HIV-infected women in Brazil", Antivir Ther, 16, pp.349~356 (2011)
  76. Becquet R, "Universal antiretroviral therapy among pregnant and postpartum HIV-infected women would improve maternal health and decrease postnatal HIV transmission", AIDS, 24, pp.1239~1241 (2010)
  77. Becquet R, "Universal antiretroviral therapy for pregnant and breast-feeding HIV-1-infected women: towards the elimination of mother-to-child transmission of HIV-1 in resource-limited settings", Clin Infect Dis, 49, pp.1936~1945 (2009)
  78. Townsend CL, "Low rates of motherto-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006", AIDS, 22, pp.973~981 (2008)
  79. Tubiana R, "Factors associated with mother-to-child transmission of HIV-1 despite a maternal viral load <500 copies", ml at delivery: a case-control study nested in the French perinatal cohort (EPF-ANRS CO1), 2010, pp.50, 585~596
  80. Mandelbrot L, "No perinatal HIV-1 transmission from women with effective antiretroviral therapy starting before conception", Clin Infect Dis, 61, pp.1715~1725 (2015)
  81. Favarato G, "Migrant women living with HIV in Europe: are they facing inequalities in the prevention of mother-to-child-transmission of HIV?: The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord", Eur J Public Health, 28, pp.55~60 (2018)
  82. Anonymous, "ACOG committee opinion no. 751: Labor and delivery management of women with human immunodeficiency virus infection", Obstet Gynecol, 132, pp.e131~e137 (2018)
  83. Alagaratnam J, "An observational study of initial HIV RNA decay following initiation of combination antiretroviral treatment during pregnancy", AIDS Res Ther, 17, pp.41~ (2020)
  84. Read PJ, "When should HAART be initiated in pregnancy to achieve an undetectable HIV viral load by delivery?", AIDS, 26, pp.1095~1103 (2012)
  85. Briand N, "Is intrapartum intravenous zidovudine for prevention of mother-to-child HIV-1 transmission still useful in the combination antiretroviral therapy era?", Clin Infect Dis, 57, pp.903~914 (2013)
  86. Cotter AM, "Duration of membrane rupture and risk of perinatal transmission of HIV-1 in the era of combination antiretroviral therapy", Am J Obstet Gynecol, 207, pp.482.e1~482.e5 (2012)
  87. Townsend CL, "Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011", AIDS, 28, pp.1049~1057 (2014)
  88. Yudin MH, "HIV and infant feeding in resource-rich settings: considering the clinical significance of a complicated dilemma", AIDS Care, 28, pp.1023~1026 (2016)
  89. Wade NA, "Abbreviated regimens of zidovudine prophylaxis and perinatal transmission of the human immunodeficiency virus", N Engl J Med, 339, pp.1409~1414 (1998)
  90. Nielsen-Saines K, "Three postpartum antiretroviral regimens to prevent intrapartum HIV infection", N Engl J Med, 366, pp.2368~2379 (2012)

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