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국내 대학병원 환자의 호흡기 검체에서 분리된 세균에 대한 Gatifloxacin의 시험관내 항균력

In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea

김성규|김명숙|김신영|이경원|용동은|정윤섭|이일섭
대한감염학회 (The Korean Society Of Infectious Diseases)|2004.04|Infection and Chemotherapy|제36권 제2호|pp. 68-74

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초록

목 적 : 새로 개발된 8-methoxyquinolone인 gatifloxacin은 호흡기 감염균을 포함한 광범위 세균에 항균력을 보인다. 본 연구에서 저자들은 gatifloxacin과 비교약제의 시험관내 항균력을 최근 우리나라 환자의 호흡기에서 분리된 세균에 대하여 시험하였다. 방 법 : 본 저자들은 2000-2001년에 국내 8개 대학병원에서 만성 하부기도 감염증이 급성 악화된 환자의 호흡기 검체에서 분리된 세균 49주와 연세의대 병원 환자의 호흡기 검체에서 분리된 병원균 108균주를 대상으로 하였다. 항균제 최소억제 농도는 NCCLS 한천희석법으로 시험하였다. 결 과 : Streptococcus pneumoniae에 대한 gatifloxacin의 MIC90는 1 g/mL로서 ciprofloxacin과 levofloxacin의 MIC90보다 각각 8배와 2배 낮았다. Haemophilus influenzae와 Moraxella (Branhamella) catarrhalis는 각각 gatifloxacin ≤0.06 g/mL와 ≤0.25 g/mL에서 억제되었고 시험한 fluoroquinolones제에 모두 감수성이었다. Klebsiella pneumoniae에 대한 gatifloxacin의 MIC90는 0.06 g/mL으로 levofloxacin과 moxifloxacin의 MIC90보다 2배 낮았다. 결 론:Gatifloxacin은 국내 환자의 호흡기병원에서 분리된 세균인 S. pneumoniae, H. influenzae 및 M. (B.) catarrhalis에 대한 시험관내 항균력이 우수하였다.

Abstract

Background:Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals. Methods:Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method. Results:MIC90 of gatifloxacin for Streptococcus pneumoniae was 1 µg/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus influenzae and Moraxella (Branhamella) catarrhalis were inhibited by ≤0.06 µg/mL and ≤0.25 µg/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MIC90 of gatifloxacin for Klebsiella pneumoniae was 0.06 µg/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin. Conclusion:Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.

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