한국 영유아의 비강 내 집락된 Moraxella catarrhalis
Nasopharyngeal Colonization of Moraxella catarrhalis in Young Korean Children
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Nasopharyngeal bacterial flora can cause respiratory tract diseases as well as invasive bacterial diseases. Moraxella catarrhalis colonizing in the nasopharynx is considered an important potential pathogen with an increasing production of β-lactamase. This study examined the nasopharyngeal colonization rate of M. catarrhalis and the antibiotic susceptibility of M. catarrhalis . Materials and Methods: Healthy children who visited one of the three University hospitals in the Republic of Korea or attended a day-care center around the participating hospitals were enrolled in this study. The nasopharyngeal samples were obtained by nasopharyngeal washing with normal saline and M. catarrhalis was isolated. The nasopharyngeal colonization rate of M. catarrhalis was investigated and the minimal inhibitory concentrations (MICs) were measured for commonly used oral antibiotics (amoxicillin, amoxicillin/clavulanate, cefaclor, cefixime, cefdinir,cefditoren, erythromycin and trimethoprim). Results: Three hundred and seventy-nine children aged between 6 months and 5years were enrolled, and the nasopharyngeal colonization rate of M. catarrhalis was 33% (124 children). All isolated M. catarrhalis produced β-lactamase. The MIC90 of the antibiotics were as follows: amoxicillin, >16 mg/L; amoxicillin/clavulanate, 0.5mg/L; cefaclor, 8 mg/L ; cefixime, 0.125 mg/L; cefdinir, 0.25 mg/L; cefditoren, 0.25mg/L; erythromycin, 0.5 mg/L; and trimethoprim, >16 mg/L. Conclusions: M. catarrhalis was colonized in 33% of the children aged 6 months to 5 years, and showed low MICs for amoxicillin/clavulanate and oral 2nd and 3rd generation cephalosporins.
Abstract
Background: Nasopharyngeal bacterial flora can cause respiratory tract diseases as well as invasive bacterial diseases. Moraxella catarrhalis colonizing in the nasopharynx is considered an important potential pathogen with an increasing production of β-lactamase. This study examined the nasopharyngeal colonization rate of M. catarrhalis and the antibiotic susceptibility of M. catarrhalis . Materials and Methods: Healthy children who visited one of the three University hospitals in the Republic of Korea or attended a day-care center around the participating hospitals were enrolled in this study. The nasopharyngeal samples were obtained by nasopharyngeal washing with normal saline and M. catarrhalis was isolated. The nasopharyngeal colonization rate of M. catarrhalis was investigated and the minimal inhibitory concentrations (MICs) were measured for commonly used oral antibiotics (amoxicillin, amoxicillin/clavulanate, cefaclor, cefixime, cefdinir,cefditoren, erythromycin and trimethoprim). Results: Three hundred and seventy-nine children aged between 6 months and 5years were enrolled, and the nasopharyngeal colonization rate of M. catarrhalis was 33% (124 children). All isolated M. catarrhalis produced β-lactamase. The MIC90 of the antibiotics were as follows: amoxicillin, >16 mg/L; amoxicillin/clavulanate, 0.5mg/L; cefaclor, 8 mg/L ; cefixime, 0.125 mg/L; cefdinir, 0.25 mg/L; cefditoren, 0.25mg/L; erythromycin, 0.5 mg/L; and trimethoprim, >16 mg/L. Conclusions: M. catarrhalis was colonized in 33% of the children aged 6 months to 5 years, and showed low MICs for amoxicillin/clavulanate and oral 2nd and 3rd generation cephalosporins.
참고문헌 (27)
- García-Rodríguez JA., "Dynamics of nasopharyngeal colonization by potential respiratory pathogens", J Antimicrob Chemother, 50(Suppl S2), pp.59~73 (2002)
- Berner R., "Colonization and infection with Moraxella catarrhalis in childhood", Eur J Clin Microbiol Infect Dis, 15, pp.506~509 (1996)
- De Lencastre H., "Carriage of respiratory tract pathogens and molecular epidemiology of Streptococcus pneumoniae colonization in healthy children attending day care centers in Lisbon, Portugal", Microb Drug Resist, 5, pp.19~29 (1999)
- Quiñones D., "Nasopharyngeal colonization by Moraxella catarrhalis and study of antimicrobial susceptibility in healthy children from Cuban day-care centers", Arch Med Res, 36, pp.80~82 (2005)
- Mackenzie GA., "Epidemiology of nasopharyngeal carriage of respiratory bacterial pathogens in children and adults : cross-sectional surveys in a population with high rates of pneumococcal disease", BMC Infect Dis, 10, pp.304~ (2010)
- American Academy of Pediatrics Subcommittee on Management of Acute Otitis Media., "Diagnosis and management of acute otitis media", Pediatrics, 113, pp.1451~1465 (2004)
- Vergison A., "Microbiology of otitis media: a moving target", Vaccine, 26(Suppl 7), pp.G5~G10 (2008)
- Casey JR., "Changes in frequency and pathogens causing acute otitis media in 1995-2003", Pediatr Infect Dis J, 23, pp.824~828 (2004)
- Casey JR., "New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine", Pediatr Infect Dis J, 29, pp.304~309 (2010)
- Faden H., "Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda", Williamsville Pediatrics, 1997, pp.175, 1440~1445
- Revai K., "Association of nasopharyngeal bacterial colonization during upper respiratory tract infection and the development of acute otitis media.", Clin Infect Dis, 46, pp.e34~e37 (2008)
- Syrjänen RK., "Pneumococcal acute otitis media in relation to pneumococcal nasopharyngeal carriage", Pediatr Infect Dis J, 24, pp.801~806 (2005)
- 김선미, "국내 소아의 비강 내 폐구균 보균율과 혈청형에 관한 역학연구", Korean Journal of Pediatrics, 47(6), pp.611~616 (2004), 대한소아과학회
- 김경효, "Nasopharyngeal Pneumococcal Carriage of Children Attending Day Care Centers in Korea: Comparison between Children Immunized with 7-valent Pneumococcal Conjugate Vaccine and Non-immunized", Journal of Korean Medical Science, 26(2), pp.184~190 (2011), 대한의학회
- Clinical and Laboratory Standards Institute, "Haemophilus influenzae and Haemophilus parainfluenzae. Performance standards for antimicrobial susceptibility testing; 20th informational supplement. Document M100-S20", Wayne, PA; CLSI, 30, pp.80~83 (2010)
- Murphy TF., "Moraxella catarrhalis, a human respiratory tract pathogen", Clin Infect Dis, 49, pp.124~131 (2009)
- McGregor K., "Moraxella catarrhalis : clinical significance, antimicrobial susceptibility and BRO beta-lactamases", Eur J Clin Microbiol Infect Dis, 17, pp.219~234 (1998)
- Broides A., "Acute otitis media caused by Moraxella catarrhalis : epidemiologic and clinical characteristics", Clin Infect Dis, 49, pp.1641~1647 (2009)
- Verduin CM., "Moraxella catarrhalis : from emerging to established pathogen", Clin Microbiol Rev, 15, pp.125~144 (2002)
- Berk SL., "Antibiotic susceptibility patterns of community-acquired respiratory isolates of Moraxella catarrhalis in western Europe and in the USA. The Alexander Project Collaborative Group", J Antimicrob Chemother, 38(Suppl A), pp.85~96 (1996)
- Hsu SF., "Antimicrobial resistance of Moraxella catarrhalis isolates in Taiwan", J Microbiol Immunol Infect, 45, pp.134~140 (2012)
- Gunnarsson RK., "The prevalence of potential pathogenic bacteria in nasopharyngeal samples from healthy children and adults", Scand J Prim Health Care, 16, pp.13~17 (1998)
- van Gils EJ., "Effect of 7-valent pneumococcal conjugate vaccine on nasopharyngeal carriage with Haemophilus influenzae and Moraxella catarrhalis in a randomized controlled trial", Vaccine, 29, pp.7595~7598 (2011)
- Jourdain S., "Differences in nasopharyngeal bacterial carriage in preschool children from different socio-economic origins", Clin Microbiol Infect, 17, pp.907~914 (2011)
- Pingault NM., "Antimicrobial susceptibility of Moraxella catarrhalis isolated from children in Kalgoorlie-Boulder, Western Australia", Pathology, 42, pp.273~279 (2010)
- Harrison CJ., "Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics", J Antimicrob Chemother, 63, pp.511~519 (2009)
- Ahmad F., "Antimicrobial susceptibility of Branhamella catarrhalis isolates from bronchopulmonary infections", Antimicrob Agents Chemother, 26, pp.424~425 (1984)