Infected Aortic Aneurysm caused by Mycobacterium bovis after Intravesical Bacillus Calmette-Guérin Treatment for Bladder Cancer
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A 70-year-old man presented with lower back pain and cyanotic changes in his left lower extremity. He was diagnosed with infected aortic aneurysm and infectious spondylitis. He had received intravesical Bacillus Calmette-Guérin (BCG) therapy up to 1 month before the onset of symptoms. The aneurysm was excised and an aorto-biiliac interposition graft was performed. Mycobacterium tuberculosis complex was cultured in the surgical specimens. Real-time polymerase chain reaction (PCR) targeting the senX3-regX3 region, and multiplex PCR using dual-priming oligonucleotide primers targeting the RD1 gene, revealed that the organism isolated was Mycobacterium bovis BCG. The patient took anti-tuberculosis medication for 1 year, and there was no evidence of recurrence at 18 months follow-up.
Abstract
A 70-year-old man presented with lower back pain and cyanotic changes in his left lower extremity. He was diagnosed with infected aortic aneurysm and infectious spondylitis. He had received intravesical Bacillus Calmette-Guérin (BCG) therapy up to 1 month before the onset of symptoms. The aneurysm was excised and an aorto-biiliac interposition graft was performed. Mycobacterium tuberculosis complex was cultured in the surgical specimens. Real-time polymerase chain reaction (PCR) targeting the senX3-regX3 region, and multiplex PCR using dual-priming oligonucleotide primers targeting the RD1 gene, revealed that the organism isolated was Mycobacterium bovis BCG. The patient took anti-tuberculosis medication for 1 year, and there was no evidence of recurrence at 18 months follow-up.
참고문헌 (17)
- Gontero P, "The role of bacillus Calmette-Guérin in the treatment of non–muscle-invasive bladder cancer", Eur Urol, 57, pp.410~429 (2010)
- 권효진, "Severe Osteomyelitis as a Complication of Tokyo-172 BCG Vaccination", Journal of Korean Medical Science, 27(2), pp.221~224 (2012), 대한의학회
- Stone MM, "Meningitis due to iatrogenic BCG Infection in two immunocompromised children", N Engl J Med, 333, pp.561~563 (1995)
- Lamm DL, "Incidence and treatment of complications of bacillus Calmette-Guerin intravesical therapy in superficial bladder cancer", J Urol, 147, pp.596~600 (1992)
- Koya MP, "Complications of intravesical therapy for urothelial cancer of the bladder", J Urol, 175, pp.2004~2010 (2006)
- Lee HR, "Novel multiplex PCR using dual-priming oligonucleotides for detection and discrimination of the Mycobacterium tuberculosis complex and M. bovis BCG", J Clin Microbiol, 48, pp.4612~4614 (2010)
- Kim SH, "BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method", Vaccine, 26, pp.4379~4381 (2008)
- Chung JY, "Analysis of the immunologic mechanism of intravesical bacillus Calmette-Guerin therapy for superficial bladder tumors:distribution and function of immune cells", J Korean Med Sci, 8, pp.135~144 (1993)
- 정준표, "방광암 환자에서 방광내 BCG 점적술 시행 후 발생한 육아종성 간염 1예", 대한소화기학회지, 39(5) (2002), 대한소화기학회
- Lee GS, "Two cases of pulmonary complications following intravesical bacillus Calmette-Gurin immunotherapy in patients with superficial bladder cancer", Tuberc Respir Dis, 46, pp.869~878 (1999)
- Dahl T, "Ruptured abdominal aortic aneurysm secondary to tuberculous spondylitis", Int Angiol, 24, pp.98~101 (2005)
- Samadian S, "Mycobacterium bovis vertebral osteomyelitis and discitis with adjacent mycotic abdominal aortic aneurysm caused by intravesical BCG therapy: a case report in an elderly gentleman", Age Ageing, 42, pp.129~131 (2013)
- Gonzalez OY, "Spectrum of bacille Calmette- Guérin (BCG) infection after intravesical BCG immunotherapy", Clin Infect Dis, 36, pp.140~148 (2003)
- Harding GE, "Ruptured mycotic abdominal aortic aneurysm secondary to Mycobacterium bovis after intravesical treatment with bacillus Calmette-Guérin", J Vasc Surg, 46, pp.131~134 (2007)
- Coscas R, "Multiple mycotic aneurysms due to Mycobacterium bovis after intravesical bacillus Calmette-Guérin therapy", J Vasc Surg, 50, pp.1185~1190 (2009)
- Sylvester RJ, "Bacillus Calmette-Guérin treatment of nonmuscle invasive bladder cancer", Int J Urol, 18, pp.113~120 (2011)
- Ritz N, "Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics", Antimicrob Agents Chemother, 53, pp.316~318 (2009)