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Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report

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초록

Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.

Abstract

Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.

참고문헌 (8)

  1. Pérez-Jacoiste Asín MA, "Bacillus Calmette-Guérin(BCG)infection following intravesical BCG administration as adjunctive therapy for bladder cancer : incidence, risk factors, and outcome in a single-institution series and review of the literature", Medicine(Baltimore), 93, pp.236~254 (2014)
  2. Mendes P, "Statin-induced rhabdomyolysis : a comprehensive review of case reports", Physiother Can, 66, pp.124~132 (2014)
  3. Akimoto H, "Onset timing of statin-induced musculoskeletal adverse events and concomitant drug-associated shift in onset timing of MAEs", Pharmacol Res Perspect, 6, pp.e00439~ (2018)
  4. Armstrong RW, "Complications after intravesical instillation of bacillus Calmette-Guerin : rhabdomyolysis and metastatic infection", J Urol, 145, pp.1264~1266 (1991)
  5. Peyrière H, "Fatal systemic reaction after multiple doses of intravesical bacillus Calmette-Guérin for polyposis", Ann Pharmacother, 34, pp.1279~1282 (2000)
  6. Dalakas MC, "Toxic and drug-induced myopathies", J Neurol Neurosurg Psychiatry, 80, pp.832~838 (2009)
  7. Valiyil R, "Drug-related myopathies of which the clinician should be aware", Curr Rheumatol Rep, 12, pp.213~220 (2010)
  8. Lyons D, "Systemic hypersensitivity reaction to intravesical BCG", Scott Med J, 39, pp.49~50 (1994)

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