Fecal Transplantation using a Nasoenteric Tube during an Initial Episode of Severe Clostridium difficile Infection
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
The incidence of Clostridium difficile infection is increasing worldwide, and its severity and resulting mortality are also on the rise. Metronidazole and oral vancomycin remain the treatments of choice, but there are concerns about treatment failure and the appearance of resistant strains. Furthermore, antibiotic therapy results in recurrence rates of at least 20%. Fecal transplantation may be a feasible treatment option for recurrent C. difficile infection; moreover, it may be an early treatment option for severe C. difficile infection. We report a case of severe C. difficile infection treated with fecal transplantation using a nasoenteric tube during an initial episode. This is the first reported case of fecal transplantation using a nasoenteric tube during an initial episode of C. difficile infection in Korea.
Abstract
The incidence of Clostridium difficile infection is increasing worldwide, and its severity and resulting mortality are also on the rise. Metronidazole and oral vancomycin remain the treatments of choice, but there are concerns about treatment failure and the appearance of resistant strains. Furthermore, antibiotic therapy results in recurrence rates of at least 20%. Fecal transplantation may be a feasible treatment option for recurrent C. difficile infection; moreover, it may be an early treatment option for severe C. difficile infection. We report a case of severe C. difficile infection treated with fecal transplantation using a nasoenteric tube during an initial episode. This is the first reported case of fecal transplantation using a nasoenteric tube during an initial episode of C. difficile infection in Korea.
참고문헌 (16)
- Pépin J, "Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003:a changing pattern of disease severity", CMAJ, 171, pp.466~472 (2004)
- Loo VG, "A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality", N Engl J Med, 353, pp.2442~2449 (2005)
- Muto CA, "A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use", Infect Control Hosp Epidemiol, 26, pp.273~280 (2005)
- Kelly CP, "Clostridium difficile--more difficult than ever", N Engl J Med, 359, pp.1932~1940 (2008)
- Rineh A, "Clostridium difficile infection: molecular pathogenesis and novel therapeutics", Expert Rev Anti Infect Ther, 12, pp.131~150 (2014)
- Borody TJ, "Fecal microbiota transplantation: indications, methods, evidence, and future directions", Curr Gastroenterol Rep, 15, pp.337~ (2013)
- van Nood E, "Duodenal infusion of donor feces for recurrent Clostridium difficile", N Engl J Med, 368, pp.407~415 (2013)
- Borody TJ, "Could fecal microbiota transplantation cure all Clostridium difficile infections?", Future Microbiol, 9, pp.1~3 (2014)
- 권태근, "대변 세균총 이식으로 치료된 난치성 위막성 대장염 2예", 대한내과학회지, 84(3), pp.395~399 (2013), 대한내과학회[DOI]
- 문강륜, "관장을 통한 대변 이식으로 완치된 치료 저항성 및 반복적 Clostridium difficile 감염", Annals of geriatric medicine and research, 17(3), pp.152~156 (2013), 대한노인병학회
- McCune VL, "Faecal transplantation for the treatment of Clostridium difficile infection: a review", Int J Antimicrob Agents, 43, pp.201~206 (2014)
- Brandt LJ, "An overview of fecal microbiota transplantation: techniques, indications, and outcomes", Gastrointest Endosc, 78, pp.240~249 (2013)
- Zainah H, "Intestinal microbiota transplantation, a simple and effective treatment for severe and refractory Clostridium difficile infection", Dig Dis Sci, 60, pp.181~185 (2015)
- Brandt LJ, "Endoscopic fecal microbiota transplantation: "first-line" treatment for severe Clostridium difficile infection?", J Clin Gastroenterol, 45, pp.655~657 (2011)
- Gough E, "Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy)for recurrent Clostridium difficile infection", Clin Infect Dis, 53, pp.994~1002 (2011)
- Postigo R, "Colonoscopic versus nasogastric fecal transplantation for the treatment of Clostridium difficile infection: a review and pooled analysis", Infection, 40, pp.643~648 (2012)