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MALDI-TOF-MS Fingerprinting Provides Evidence of Urosepsis caused by Aerococcus urinae

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Urosepsis due to Aerococcus urinae is rare in clinical settings with only a few of reported cases worldwide by 16S rRNA sequencing. Here we report a case of sepsis caused by A. urinae in a 86 year-old male with complicated urinary tract infection which was confirmed through peptide mass fingerprinting of matrix-assisted laser desorption ionization time of flight mass spectrometry.

Abstract

Urosepsis due to Aerococcus urinae is rare in clinical settings with only a few of reported cases worldwide by 16S rRNA sequencing. Here we report a case of sepsis caused by A. urinae in a 86 year-old male with complicated urinary tract infection which was confirmed through peptide mass fingerprinting of matrix-assisted laser desorption ionization time of flight mass spectrometry.

참고문헌 (10)

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  3. Schuur PM, "Urinary tract infections with Aerococcus urinae in the south of The Netherlands", Eur J Clin Microbiol Infect Dis, 16, pp.871~875 (1997)
  4. de Jong MF, "Aerococcus urinae: severe and fatal bloodstream infections and endocarditis", J Clin Microbiol, 48, pp.3445~3447 (2010)
  5. Colakoglu S, "Three cases of serious infection caused by Aerococcus urinae: a patient with spontaneous bacterial peritonitis and two patients with bacteremia", Infection, 36, pp.288~290 (2008)
  6. Schuur PM, "Three cases of serious infection caused by Aerococcus urinae", Eur J Clin Microbiol Infect Dis, 18, pp.368~371 (1999)
  7. Interpretive criteria for identification of bacteria and fungi by DNA target sequencing: approved guideline, "Clinical and Laboratory Standards Institute (CLSI)", CLSI, ~ (2008)
  8. Senneby E, "Matrix- assisted laser desorption ionization-time of flight mass spectrometry is a sensitive and specific method for identification of aerococci", J Clin Microbiol, 51, pp.1303~1304 (2013)
  9. Sørensen SM, "The role of imaging of the urinary tract in patients with urosepsis", Int J Infect Dis, 17, pp.e299~e303 (2013)
  10. Sturm PD, "Urosepsis with Actinobaculum schaalii and Aerococcus urinae", J Clin Microbiol, 44, pp.652~654 (2006)

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