Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications
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Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Due to their unique physicochemical characteristics, PFASs have been used as surfactants and surface coating materials in many applications. Therefore, PFASs have been frequently detected in humans and environment worldwide. In cross-sectional studies using nationally representative general human populations of United States, several PFASs have shown significant associations with thyroid hormones. Moreover, among pregnant women and their infants, not only major PFASs such as perfluorooctane sulfonic acid and perfluorooctanoic acid, but also those with shorter or longer carbon chains showed significant associations with thyroid hormones. Often demographic characteristics such as sex, age, and disease status appear to influence the associations between PFASs exposure and thyroid hormones. In general, major PFASs showed hypothyroidism effects among pregnant women and infants. As 8 carbon based PFASs have been phased out, those with shorter or longer carbon chains have been used in growing amount as replacement. However, only limited information is available for their occurrences and toxicity among humans. Further investigations on these substituting PFASs are required. In addition, efforts are warranted to identify sources of and mitigate exposure to these thyroid disrupting chemicals especially during pregnancy and early stages of life.
Abstract
Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects including neurodevelopmental disorders. Perfluoroalkyl substances (PFASs) are among the thyroid disrupting chemicals that can be encountered among general human population. Due to their unique physicochemical characteristics, PFASs have been used as surfactants and surface coating materials in many applications. Therefore, PFASs have been frequently detected in humans and environment worldwide. In cross-sectional studies using nationally representative general human populations of United States, several PFASs have shown significant associations with thyroid hormones. Moreover, among pregnant women and their infants, not only major PFASs such as perfluorooctane sulfonic acid and perfluorooctanoic acid, but also those with shorter or longer carbon chains showed significant associations with thyroid hormones. Often demographic characteristics such as sex, age, and disease status appear to influence the associations between PFASs exposure and thyroid hormones. In general, major PFASs showed hypothyroidism effects among pregnant women and infants. As 8 carbon based PFASs have been phased out, those with shorter or longer carbon chains have been used in growing amount as replacement. However, only limited information is available for their occurrences and toxicity among humans. Further investigations on these substituting PFASs are required. In addition, efforts are warranted to identify sources of and mitigate exposure to these thyroid disrupting chemicals especially during pregnancy and early stages of life.
참고문헌 (49)
- Christensen DL, "Prevalence and characteristics of autism spectrum disorder among children aged 8 years: autism and developmental disabilities monitoring network, 11 sites, United States, 2012", MMWR Surveill Summ, 65, pp.1~23 (2016)
- Weintraub K, "The prevalence puzzle: Autism counts", Nature, 479, pp.22~24 (2011)
- Bergman A, "State of the science of endocrine disrupting chemicals – 2012" (2013), United Nations Environment Programme (UNEP) and World Health Organization (WHO)
- Porterfield SP, "The role of thyroid hormones in prenatal and neonatal neurological development: current perspectives", Endocr Rev, 14, pp.94~106 (1993)
- Ballesteros V, "Exposure to perfluoroalkyl substances and thyroid function in pregnant women and children: a systematic review of epidemiologic studies", Environ Int, 99, pp.15~28 (2017)
- Kristen Lyall, "Neonatal thyroid hormone levels in association with autism spectrum disorder", Autism Research, 10(4), pp.585~592 (2017), Wiley-Blackwell[DOI]
- Korevaar TI, "Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: a population-based prospective cohort study", Lancet Diabetes Endocrinol, 4, pp.35~43 (2016)
- Boas M, "Thyroid effects of endocrine disrupting chemicals", Mol Cell Endocrinol, 355, pp.240~248 (2012)
- Coperchini F, "Thyroid disruption by perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA)", J Endocrinol Invest, 40, pp.105~121 (2017)
- Naile JE, "Transcriptional effects of perfluorinated compounds in rat hepatoma cells", Chemosphere, 86, pp.270~277 (2012)
- Buck RC, "Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins", Integr Environ Assess Manag, 7, pp.513~541 (2011)
- Kissa E, "Fluorinated surfactants and repellants" (2001), Marcel Dekker Inc
- Chang SC, "Comparative pharmacokinetics of perfluorobutyrate in rats, mice, monkeys, and humans and relevance to human exposure via drinking water", Toxicol Sci, 104, pp.40~53 (2008)
- Nilsson H, "A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax", Environ Sci Technol, 44, pp.2150~2155 (2010)
- Olsen GW, "Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers", Environ Health Perspect, 115, pp.1298~1305 (2007)
- Olsen GW, "A comparison of the pharmacokinetics of perfluorobutanesulfonate (PFBS) in rats, monkeys, and humans", Toxicology, 256, pp.65~74 (2009)
- Chengelis CP, "Comparison of the toxicokinetic behavior of perfluorohexanoic acid (PFHxA) and nonafluorobutane-1-sulfonic acid (PFBS) in cynomolgus monkeys and rats", Reprod Toxicol, 27, pp.400~406 (2009)
- Ohmori K, "Comparison of the toxicokinetics between perfluorocarboxylic acids with different carbon chain length", Toxicology, 184, pp.135~140 (2003)
- Tatum-Gibbs K, "Comparative pharmacokinetics of perfluorononanoic acid in rat and mouse", Toxicology, 281, pp.48~55 (2011)
- Sundström M, "Comparative pharmacokinetics of perfluorohexanesulfonate (PFHxS) in rats, mice, and monkeys", Reprod Toxicol, 33, pp.441~451 (2012)
- Chang SC, "Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys", Reprod Toxicol, 33, pp.428~440 (2012)
- Kato S, "Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children's Health", Environ Health Prev Med, 21, pp.334~344 (2016)
- Kang H, "Elevated levels of short carbon-chain PFCAs in breast milk among Korean women: Current status and potential challenges", Environ Res, 148, pp.351~359 (2016)
- Eriksson U, "Temporal trends of PFSAs, PFCAs and selected precursors in Australian serum from 2002 to 2013", Environ Pollut, 220(Pt A), pp.168~177 (2017)
- Melzer D, "Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey", Environ Health Perspect, 118, pp.686~692 (2010)
- Wen LL, "Association between serum perfluorinated chemicals and thyroid function in U.S. adults: the National Health and Nutrition Examination Survey 2007-2010", J Clin Endocrinol Metab, 98, pp.E1456~E1464 (2013)
- Lewis RC, "Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012", Int J Environ Res Public Health, 12, pp.6098~6114 (2015)
- Webster GM, "Cross-sectional associations of serum perfluoroalkyl acids and thyroid hormones in U.S. adults: variation according to TPOAb and iodine status (NHANES 2007-2008)", Environ Health Perspect, 124, pp.935~942 (2016)
- Jain RB, "Association between thyroid profile and perfluoroalkyl acids: data from NHNAES 2007-2008", Environ Res, 126, pp.51~59 (2013)
- Ji K, "Serum concentrations of major perfluorinated compounds among the general population in Korea: dietary sources and potential impact on thyroid hormones", Environ Int, 45, pp.78~85 (2012)
- Harada K, "Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their speciesspecific excretion", Environ Res, 99, pp.253~261 (2005)
- Krassas GE, "Thyroid function and human reproductive health", Endocr Rev, 31, pp.702~755 (2010)
- Wiens SC, "The effects of 17β-estradiol injections on thyroid hormone deiodination pathways in liver and other tissues of female and male rainbow trout (Oncorhynchus mykiss) at different stages of sexual maturity", Can J Zool, 83, pp.596~603 (2005)
- Leatherland JF, "Effects of 17 beta-estradiol and methyl testosterone on the activity of the thyroid gland in rainbow trout, Salmo gairdneri Richardson", Gen Comp Endocrinol, 60, pp.343~352 (1985)
- Webster GM, "Associations between perfluoroalkyl acids (PFASs) and maternal thyroid hormones in early pregnancy: a population-based cohort study", Environ Res, 133, pp.338~347 (2014)
- Berg V, "Assessing the relationship between perfluoroalkyl substances, thyroid hormones and binding proteins in pregnant women; a longitudinal mixed effects approach", Environ Int, 77, pp.63~69 (2015)
- Wang Y, "Association between perfluoroalkyl substances and thyroid stimulating hormone among pregnant women: a cross-sectional study", Environ Health, 12, pp.76~ (2013)
- Wang Y, "Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study", Environ Health Perspect, 122, pp.529~534 (2014)
- Yang L, "Placental transfer of perfluoroalkyl substances and associations with thyroid hormones: Beijing Prenatal Exposure Study", Sci Rep, 6, pp.21699~ (2016)
- de Cock M, "Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in infants: a Dutch prospective cohort study", Environ Health, 13, pp.106~ (2014)
- Shah-Kulkarni S, "Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls", Environ Int, 94, pp.607~613 (2016)
- Kim S, "Transplacental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones", Environ Sci Technol, 45, pp.7465~7472 (2011)
- Chan E, "Perfluorinated acids and hypothyroxinemia in pregnant women", Environ Res, 111, pp.559~564 (2011)
- Song M, "Changes in thyroid peroxidase activity in response to various chemicals", J Environ Monit, 14, pp.2121~2126 (2012)
- Weiss JM, "Competitive binding of polyand perfluorinated compounds to the thyroid hormone transport protein transthyretin", Toxicol Sci, 109, pp.206~216 (2009)
- Yu WG, "Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism", Environ Toxicol Chem, 28, pp.990~996 (2009)
- Park C, "Associations between urinary phthalate metabolites and bisphenol A levels, and serum thyroid hormones among the Korean adult population - Korean National Environmental Health Survey (KoNEHS) 2012-2014", Sci Total Environ, 584-585, pp.950~957 (2017)
- Kim S, "Association between several persistent organic pollutants and thyroid hormone levels in cord blood serum and bloodspot of the newborn infants of Korea", PLoS One, 10, pp.e0125213~ (2015)
- Kim S, "Association between several persistent organic pollutants and thyroid hormone levels in serum among the pregnant women of Korea", Environ Int, 59, pp.442~448 (2013)