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Ambient air pollution and endocrinologic disorders in childhood

Kim Hae Soon|Heo You Joung
대한소아내분비학회 (Korean Society Of Pediatric Endocrinology)|2021.09|Annals of Pediatric Endocrinology & Metabolism|제26권 제3호|pp. 158-170|DOI 10.6065/apem.2142132.066

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키워드

PediatricsAir pollutionEndocrinology
주제분류소아과학

초록

Ambient air pollution has been proposed as an important environmental risk factor that increases global mortality and morbidity. Over the past decade, several human and animal studies have reported an association between exposure to air pollution and altered metabolic and endocrine systems in children. However, the results for these studies were mixed and inconclusive and did not demonstrate causality because different outcomes were observed due to different study designs, exposure periods, and methodologies for exposure measurements. Current proposed mechanisms include altered immune response, oxidative stress, neuroinflammation, inadequate placental development, and epigenetic modulation. In this review, we summarized the results of previous pediatric studies that reported effects of prenatal and postnatal air pollution exposure on childhood type 1 diabetes mellitus, obesity, insulin resistance, thyroid dysfunction, and timing of pubertal onset, along with underlying related mechanisms.

Abstract

Ambient air pollution has been proposed as an important environmental risk factor that increases global mortality and morbidity. Over the past decade, several human and animal studies have reported an association between exposure to air pollution and altered metabolic and endocrine systems in children. However, the results for these studies were mixed and inconclusive and did not demonstrate causality because different outcomes were observed due to different study designs, exposure periods, and methodologies for exposure measurements. Current proposed mechanisms include altered immune response, oxidative stress, neuroinflammation, inadequate placental development, and epigenetic modulation. In this review, we summarized the results of previous pediatric studies that reported effects of prenatal and postnatal air pollution exposure on childhood type 1 diabetes mellitus, obesity, insulin resistance, thyroid dysfunction, and timing of pubertal onset, along with underlying related mechanisms.

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  99. 이정은, "Early-life exposure to endocrine-disrupting chemicals and pubertal development in girls", Annals of Pediatric Endocrinology & Metabolism, 24(2), pp.78~91 (2019), 대한소아내분비학회[DOI]

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