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Antibiotic Combination Therapy for Severe Scrub Typhus: Is It Necessary?

Im Jae Hyoung|Lee Jin-Soo|Chung Moon-Hyun
대한감염학회 (The Korean Society Of Infectious Diseases)|2023.06|Infection and Chemotherapy|제55권 제2호|pp. 179-184|DOI 10.3947/ic.2023.0055

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참고문헌

키워드

AzithromycinDoxycyclineScrub typhusOrientia tsutsugamushiDrug synergism
주제분류내과학

초록

Scrub typhus can be adequately treated with doxycycline or azithromycin unless it is treated too late. Such cases present as severe scrub typhus, and their treatment remains a challenging problem. In this article, we briefly review the literature on the treatment of scrub typhus and the limitations of the combination of doxycycline and azithromycin. Several options are suggested for further study in the treatment of severe scrub typhus (such as encephalitis, myocarditis, and pneumonia), including dose escalation of doxycycline, the adjuvant use of steroids, the selective use of beta-lactam antibiotics, and the use of tigecycline.

Abstract

Scrub typhus can be adequately treated with doxycycline or azithromycin unless it is treated too late. Such cases present as severe scrub typhus, and their treatment remains a challenging problem. In this article, we briefly review the literature on the treatment of scrub typhus and the limitations of the combination of doxycycline and azithromycin. Several options are suggested for further study in the treatment of severe scrub typhus (such as encephalitis, myocarditis, and pneumonia), including dose escalation of doxycycline, the adjuvant use of steroids, the selective use of beta-lactam antibiotics, and the use of tigecycline.

참고문헌 (28)

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관련 논문AI추천

In vitro Antagonism between Cefotaxime and Anti- Rickettsial Antibiotics against Orientia tsutsugamushi강재승, 백지현, 이선명, 이오현, 이진수, 정문현대한감염학회 · Infection and Chemotherapy2014 · 제46권 제3호In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi손동욱, 정문현대한감염학회 · Infection and Chemotherapy2014 · 제46권 제3호In Vitro Activity of Tigecycline Against Orientia tsutsugamushi강재승, 권혜윤, 백지현, 이선명, 이진수, 임재형, 정문현, 황승식연세대학교의과대학 · Yonsei Medical Journal2016 · 제57권 제4호Orientia tsutsugamushi에 대한 항균제 병용의 실험실 효과강재승, 김미경, 김은실, 이진수, 이혜명, 정문현대한감염학회 · Infection and Chemotherapy2008 · 제40권 제6호Lack of Effect of Dexamethasone on Growth of Orientia Tsutsugamushi Gilliam in Mouse L929 Cells김준명, 김창오, 송영구, 염준섭, 이꽃실, 정수진, 진범식, 최준용, 한상훈, 허애정연세대학교의과대학 · Yonsei Medical Journal2011 · 제52권 제4호Orientia tsutsugamushi 감염에서 doxycycline 용량과 투여 기간에 대한 실험강재승, 김미경, 김은실, 박재은, 이진수, 이혜명, 정문현대한감염학회 · Infection and Chemotherapy2008 · 제40권 제5호

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