Possibility of Decreasing Incidence of Human Immunodeficiency Virus Infection in Korea
2
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background: The number of newly diagnosed cases of human immunodeficiency virus (HIV) infection in Korea, which had increased until 2019, has markedly decreased since the coronavirus disease 2019 pandemic started. This study evaluated whether the decrease is due to a reduction in the incidence of HIV infection and/or delayed diagnosis during the pandemic. Materials and Methods: We reviewed the medical records of 587 newly diagnosed patients with HIV infection between February 2018 and January 2022 from four general hospitals, and their characteristics were compared between the prepandemic and pandemic periods. The lapse time from infection to diagnosis was estimated using an HIV modeling tool. Results: The estimated mean times to diagnosis were 5.68 years (95% confidence interval [CI]: 4.45 - 6.51 years) and 5.41 years (95% CI: 4.09 - 7.03 years) before and during the pandemic, respectively (P = 0.016). The proportion of patients with acquired immunodeficiency syndrome-defining illnesses, expected to visit hospitals regardless of the pandemic, decreased from 17.2% before the pandemic to 11.9% during the pandemic (P = 0.086). Conclusion: The decrease in the number of newly diagnosed cases of HIV infection in Korea might have resulted from an actual decrease in the incidence of HIV infection rather than a worsening of underdiagnosis or delayed diagnosis.
Abstract
Background: The number of newly diagnosed cases of human immunodeficiency virus (HIV) infection in Korea, which had increased until 2019, has markedly decreased since the coronavirus disease 2019 pandemic started. This study evaluated whether the decrease is due to a reduction in the incidence of HIV infection and/or delayed diagnosis during the pandemic. Materials and Methods: We reviewed the medical records of 587 newly diagnosed patients with HIV infection between February 2018 and January 2022 from four general hospitals, and their characteristics were compared between the prepandemic and pandemic periods. The lapse time from infection to diagnosis was estimated using an HIV modeling tool. Results: The estimated mean times to diagnosis were 5.68 years (95% confidence interval [CI]: 4.45 - 6.51 years) and 5.41 years (95% CI: 4.09 - 7.03 years) before and during the pandemic, respectively (P = 0.016). The proportion of patients with acquired immunodeficiency syndrome-defining illnesses, expected to visit hospitals regardless of the pandemic, decreased from 17.2% before the pandemic to 11.9% during the pandemic (P = 0.086). Conclusion: The decrease in the number of newly diagnosed cases of HIV infection in Korea might have resulted from an actual decrease in the incidence of HIV infection rather than a worsening of underdiagnosis or delayed diagnosis.
참고문헌 (20)
- "UNAIDS data 2021"[URL]
- 2021 HIV, "AIDS annual report", Korea Disease Control and Prevention Agency (KDCA), 2022
- Di Bidino R, "Impact of SARS-CoV-2 on provided healthcare. evidence from the emergency phase in Italy", Front Public Health, 8, pp.583583~ (2020)
- "HIV/AIDS surveillance in Europe 2021: 2020 data"[URL]
- "HIV surveillance report, 2020; vol. 33"[URL]
- Mitchell KM, "The potential effect of COVID-19-related disruptions on HIV incidence and HIV-related mortality among men who have sex with men in the USA : a modelling study", Lancet HIV, 8, pp.e206~15 (2021)
- Centers for Disease Control and Prevention (CDC), "Revised surveillance case definition for HIV infection--United States, 2014", MMWR Recomm Rep, 63, pp.1~10 (2014)
- van Sighem A, "Estimating HIV incidence, time to diagnosis, and the undiagnosed HIV epidemic using routine surveillance data", Epidemiology, 26, pp.653~660 (2015)
- ". Version 1.3.0"[URL]
- "ECDC HIV modelling tool user manual. Version 1.3.0" (2017)[URL]
- Sentís A, "The impact of the COVID-19 pandemic on sexually transmitted infections surveillance data : incidence drop or artefact?", BMC Public Health, 21, pp.1637~ (2021)
- Alibudbud Rowalt, "HIV Service Delivery Innovations in the Philippines during the COVID-19 Pandemic", Infection and Chemotherapy, 55(2), pp.283~284 (2023), 대한감염학회[DOI]
- Kuehn BM, "Reduced HIV testing and diagnoses during COVID-19pandemic", JAMA, 328, pp.519~ (2022)
- Kim Y, "HIV testing and new HIV diagnoses in the Republic of Korea, 2016-2020", Public Health Wkly Rep, 15, pp.713~714 (2022)
- "HIV surveillance report. HIV infection, risk, prevention, and testing behaviors among heterosexually active adults at increased risk for HIV infection-National HIV behavioral surveillance 23U.S. cities" (2019)[URL]
- "HIV surveillance report- supplemental report. Monitoring selected national HIV prevention and care objectives by using-HIV surveillance data United States and 6 dependent areas" (2020)[URL]
- Kort DN, "Sexual orientation differences in HIV testing motivation among college men", J Am Coll Health, 65, pp.223~227 (2017)
- Fauci AS, "Immunopathogenic mechanisms of HIV infection", Ann Intern Med, 124, pp.654~663 (1996)
- Aldrich J, "The effect of acute severe illness on CD4+ lymphocyte counts in nonimmunocompromised patients", Arch Intern Med, 160, pp.715~716 (2000)
- Langford SE, "Predictors of disease progression in HIV infection : a review", AIDS Res Ther, 4, pp.11~ (2007)