동양인에서 녹차 복용과 위암발생 위험도: 메타분석
Green Tea Consumption and Stomach Cancer Risk in the Asian Population:a Meta-Analysis of Prospective Studies
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
연구배경 : 실험실적 연구에서 녹차가 항암효과를 보이며 녹차의 복용이 위암의 발생률에 영향을 준다는 역학적 연구들이 있으나 결과가 일관되지 못하였다. 이에 이를 통합하여 녹차의 복용과 위암의 발생률에 관한 결론을 도출하고자 하였다. 방 법 : 총 10편의 전향적 연구에 대해 녹차의 최소 복용 군에 대한 최대 복용 군의 종합적인 RR (rate ratio or relative risk)을 추정하였으며 대상 논문들의 동질성 검정과 출판편의를 검정하였다. 또한 성별 및 복용량에 대한 RR도 분석하였으며 각 분석에 대해 모수효과 모형과 랜덤효과 모형을 모두 적용하였다. 결 과 : 모수효과 모형에서 최소 복용 군에 대한 최대 복용 군의 종합적인 RR은 분석대상 논문 전체에서 1.04 (P=0.418), 남성의 경우 1.13 (P=0.152), 여성의 경우 0.88 (P=0.31)로서 통계적 유의성이 없었다. 복용량의 경우 5컵 이상 군에서 1.01 (P=0.760), 10컵 이상 군에서 0.93 (P=0.735)로서 통계적으로 유의하지 않았다. 랜덤효과 모형에서도 또한 유의성이 없었다. 결 론 : 녹차의 복용과 위암발생의 관계를 보고자 선행 전향적 연구들을 종합하여 본 결과 녹차의 복용이 위암의 발생에 영향을 준다는 근거를 찾을 수 없었으며 복용량과 성별에 따른 차이도 확인할 수 없었다.
Abstract
Background Experimental studies have suggested that green tea and polyphenol have some anticancer activities and many epidemiologic studies have examined the possible association between green tea consumption and stomach cancer risk. This meta-analysis overviewed previous epidemiologic studies and presented the combined results. Methods Ten prospective studies and seven case-control studies were reviewed. Meta-analysis was performed on the ten prospective studies. This meta-analysis indicated the combined RR (rate ratio or relative risk) for highest versus lowest green tea consumption by using both the fixed effect model and the random effect model, and then, examined heterogeneity and publication bias. To estimate the combined RR, the general variance based method was used. To test publication bias, a funnel plot was drawn and the Egger's regression intercept test was performed. Results The combined results did not show an association between green tea consumption and stomach cancer risk(combined RR: 1.04, P value=0.418). There were no rate differences in gender and daily consumption amount. Estimates from both fixed and random effect model were nearly identical and BSV (between study variation) was negligible. This meta-analysis did not show heterogeneity (Q=14.313, P value=0.427) nor publication bias. Conclusions In contrast with some case-control studies, this study found no relation between green tea consumption and stomach cancer risk. Better designed cohort and meta-analysis studies are needed to support this meta-analysis study.
참고문헌 (34)
- Bushman JL, "Green tea and cancer in humans: a review of the literature", Nutrition and cancer, 31(3), pp.151~159 (1998)
- Demirer T, "Diet and stomach cancer incidence. A case-control study in Turkey", Cancer, 65(10), pp.2344~2348 (1990)
- Goldbohm RA, "Consumption of black tea and cancer risk: a prospective cohortstudy", Journal of the National Cancer Institute, 88(2), pp.93~100 (1996)
- Han J, "Highlights of the cancer chemoprevention studies in China", Preventive medicine, 22(5), pp.712~722 (1993)
- Kohlmeier L, "Tea and cancer prevention: an evaluation of the epidemiologic literature", Nutrition and cancer, 27(1), pp.1~13 (1997)
- Weiger WA, "Advising patients who seek complementary and alternative medical therapies for cancer", Annals of internal medicine, 137(11), pp.889~903 (2002)
- Yatsuya H, "Family history and the risk of stomach cancer death in Japan: differences by age and gender", International journal of cancer, 97(5), pp.688~694 (2002)
- Kono S, "Green tea and gastric cancer in Japan", The New England journal of medicine, 344(24), pp.1867~1868 (2001)
- Chung FL, "Tea and cancer prevention: studies in animals and humans", The Journal of nutrition, 133(10), pp.3268S~3274S (2003)
- Sano T, "Green tea and gastric cancer", The New England journal of medicine, 344(9), pp.675~676 (2001)
- Beliveau R, "Green tea: prevention and treatment of cancer by nutraceuticals", Lancet, 364(9439), pp.1021~1022 (2004)
- Lambert JD, "Mechanisms of cancer prevention by tea constituents", The Journal of nutrition, 133(10), pp.3262S~3267S (2003)
- Mukhtar H, "Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins", Cancer Res, 63, pp.8118~8121 (2003)
- Mukhtar H, "Tea polyphenols: prevention of cancer and optimizing health", The American journal of clinical nutrition, 71(6), pp.1698S~1702S (2000)
- Inoue M, "Tea and coffee consumption and the risk of digestive tract cancers: data from a comparative case-referent study in Japan", Cancer Causes Control, 9(2), pp.209~216 (1998)
- Kono S, "A case-control study of gastric cancer and diet in northern Kyushu, Japan", Jpn J Cancer Res, 79(10), pp.1067~1074 (1988)
- Setiawan VW, "Protective effect of green tea on the risks of chronic gastritis and stomach cancer", International journal of cancer, 92(4), pp.600~604 (2001)
- Yu GP, "Green-tea consumption and risk of stomach cancer: a population-based case-control study in Shanghai, China", Cancer Causes Control, 6(6), pp.532~538 (1995)
- Hoshiyama Y, "A prospective study of stomach cancer death in relation to green tea consumption in Japan", British journal of cancer, 87(3), pp.309~313 (2002)
- Hoshiyama Y, "A nested case-control study of stomach cancer in relation to green tea consumption in Japan", British journal of cancer, 90(1), pp.135~138 (2004)
- Tsubono Y, "Green tea and the risk of gastric cancer in Japan", The New England journal of medicine, 344(9), pp.632~636 (2001)
- Heahang Song, "Meta-Analysis" (2006), Cheong Moon Gak
- Sung Sam Oh, "META-ANALYSIS: Theory and Practice" (2002), Konkuk University Press
- Sun CL, "Green tea, black tea and breast cancer risk: a meta-analysis of epidemiological studies", Carcinogenesis, 27(7), pp.1310~1315 (2006)
- Sun CL, "Green tea, black tea and colorectal cancer risk: a meta-analysis of epidemiologic studies", Carcinogenesis, 27(7), pp.1301~1309 (2006)
- Hoshiyama Y, "Green tea and stomach cancer--a short review of prospective studies", Journal of epidemiology, 2005, pp.15(2), S109~S112
- Koizumi Y, "No association between green tea and the risk of gastric cancer: pooled analysis of two prospective studies in Japan", Cancer Epidemiol Biomarkers Prev, 12(5), pp.472~473 (2003)
- Petitti DB, "Meta-analysis, decision analysis, and cost-effectiveness analysis: methods for quantitative synthesis in medicine. 2nd ed" (2000), Oxford University Press
- Sasazuki S, "Green tea consumption and subsequent risk of gastric cancer by subsite: the JPHC Study", Cancer Causes Control, 15(5), pp.483~491 (2004)
- Fujino Y, "Prospective study of educational background and stomach cancer in Japan", Preventive medicine, 35(2), pp.121~127 (2002)
- Keun-young Yoo, "Categorical data analysis for epidemiological studies" (1996), Seoul National University Press
- Zhou Y, "Green tea and gastric cancer risk: meta-analysis of epidemiologic studies", Asia Pacific journal of clinical nutrition, 17(1), pp.159~165 (2008)
- Ji BT, "The influence of cigarette smoking, alcohol, and green tea consumption on the risk of carcinoma of the cardia and distal stomach in Shanghai, China", Cancer, 77(12), pp.2449~2457 (1996)
- Nagano J, "A prospective study of green tea consumption and cancer incidence, Hiroshima and Nagasaki (Japan)", Cancer Causes Control, 12(6), pp.501~508 (2001)