Genetic Epidemiology and Antimicrobial Susceptibilities of Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Multicenter Study in Korea
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Owing to concern that carbapenemase-producing strains among carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and bla NDM ST773 was the most common genotype (27 isolates, 42.9%), followed by bla NDM ST644 (9 isolates, 14.3%) and bla IMP ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.
Abstract
Owing to concern that carbapenemase-producing strains among carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates is on the rise, we investigated the genetic epidemiology and antimicrobial susceptibilities of clinical CRPA isolates collected in four academic hospitals in Korea. Carbapenemase genes were detected in 46 of 63 CRPA isolates (73.0%) collected between 2021 and 2024, and bla NDM ST773 was the most common genotype (27 isolates, 42.9%), followed by bla NDM ST644 (9 isolates, 14.3%) and bla IMP ST235 (7 isolates, 11.1%). Overall susceptibility to ceftazidime/avibactam was only 17.5%, and none of the carbapenemase-producing isolates were susceptible to it. All ST644 strains were also resistant to aztreonam.