Emergence of NDM-1–producing Pseudomonas aeruginosa Sequence Type 773 Clone: Shift of Carbapenemase Molecular Epidemiology and Spread of 16S rRNA Methylase Genes in Korea
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Imipenemase (IMP)-6–producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood isolates were obtained from nine general hospitals and two nursing homes. Twenty-four isolates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N=10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N=11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amikacin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveillance of the recently emerged NDM-1–producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbapenem- and amikacin-resistant P. aeruginosa in Korea.
Abstract
Imipenemase (IMP)-6–producing Pseudomonas aeruginosa sequence type (ST) 235 is a dominant clone of carbapenemase-producing P. aeruginosa (CPPAE) in Korea. As part of the Antimicrobial Resistance Surveillance System in Korea, we found an increase in the carbapenem resistance rate of P. aeruginosa isolates from blood cultures and a shift in the molecular epidemiology of CPPAE. A total of 212 non-duplicated P. aeruginosa blood isolates were obtained from nine general hospitals and two nursing homes. Twenty-four isolates were identified as CPPAE. We observed the emergence of the NDM-1 P. aeruginosa ST 773 clone (N=10), mostly from Gyeongsang Province. The IMP-6 ST 235 clone (N=11) was detected in all provinces. CPPAE isolates showed very high resistance rates to amikacin, and all NDM-1 P. aeruginosa strains carried rmtB. This is the first nationwide surveillance of the recently emerged NDM-1–producing P. aeruginosa ST773 clone in Korea. Continuous surveillance is necessary to prevent the infection and transmission of carbapenem- and amikacin-resistant P. aeruginosa in Korea.
참고문헌 (14)
- 유성미, "중환자실내 병원성 요로감염 실태와 전파경로: Imipenem Resistant P. aeruginosa(IRPA)의 분자역학적 특성을 중심으로", Journal of Korean Academy of Nursing, 36(8), pp.1204~1214 (2006), 한국간호과학회
- Lee JY, "OprD mutations and inactivation, expression of efflux pumps and AmpC, and metallo-β-lactamases in carbapenem-resistant Pseudomonas aeruginosa isolates from South Korea", Int J Antimicrob Agents, 40, pp.168~172 (2012)
- Yoon EJ, "Mobile carbapenemase genes in Pseudomonas aeruginosa", Front Microbiol, 12, pp.614058~ (2021)
- Yoo JS, "Dissemination of genetically related IMP-6-producing multidrug-resistant Pseudomonas aeruginosa ST235 in South Korea", Int J Antimicrob Agents, 39, pp.300~304 (2012)
- Seok Y, "Dissemination of IMP-6 metallo-β-lactamase-producing Pseudomonas aeruginosa sequence type 235 in Korea", J Antimicrob Chemother, 66, pp.2791~2796 (2011)
- Cho HH, "Prevalence and genetic analysis of multidrug-resistant Pseudomonas aeruginosa ST235 isolated from a hospital in Korea, 2008-2012", Ann Clin Lab Sci, 43, pp.414~419 (2013)
- Kim MJ, "Dissemination of metallo-β-lactamase-producing Pseudomonas aeruginosa of sequence type 235 in Asian countries", J Antimicrob Chemother, 68, pp.2820~2824 (2013)
- Lee H, "Establishment of the South Korean national antimicrobial resistance surveillance system, Kor-GLASS, in 2016", Euro Surveill, 23, pp.1700734~ (2018)
- CLSI, "Performance standards for antimicrobial susceptibility testing. 28th ed. CLSI M100", Clinical and Laboratory Standards Institute, ~ (2020)
- Hong JS, "Molecular characteristics of GES-type carbapenemase-producing Pseudomonas aeruginosa clinical isolates from long-term care facilities and general hospitals in South Korea", Microb Drug Resist, 26, pp.605~610 (2020)
- Hong JS, "Molecular characterization of the first emerged NDM-1-producing Pseudomonas aeruginosa isolates in South Korea", Microb Drug Resist, 27, pp.1063~1070 (2021)
- Farhan SM, "Effect of imipenem and amikacin combination against multi-drug resistant Pseudomonas aeruginosa", Antibiotics, 10, pp.1429~ (2021)
- Junaid K, "Molecular diversity of NDM-1, NDM-5, NDM-6, and NDM-7 variants of New Delhi metallo-β-lactamases and their impact on drug resistance", Clin Lab, 67 (2021)