Effects of the COVID-19 pandemic on serum vitamin D concentration in Korean children
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Purpose: Social distancing policies and school closures in South Korea induced by coronavirus disease 2019 have raised concerns about a lower chance of exposure to sunlight in children and adolescents. This study investigates changes in the vitamin D status of children and adolescents following the pandemic.Methods: This retrospective study includes healthy children aged 3–18 years who visited Hanyang University Hospitals in Seoul or Guri during pre-coronavirus disease 2019 (COVID-19) and post-COVID-19 pandemic periods. August 2017 to July 2019 is defined as the pre-COVID-19 pandemic period, while the period from July 2020 to July 2021 is defined as post-COVID-19 or "during the pandemic." Propensity scores were used to match the prepandemic and pandemic groups 1:1 based on age, sex, season of blood collection, and body mass index z-score to compare vitamin D status among subjects.Results: Among 786 eligible children, 506 were matched using propensity scores. There were no significant differences in mean serum 25-hydroxyvitamin D (25(OH) D) levels (20.1±6.5 ng/mL vs. 19.9±6.3 ng/mL, P>0.05) or vitamin D deficiency rates (53.0% vs. 54.9%, P>0.05) between the prepandemic and pandemic groups. Seasonal analysis revealed lower mean serum 25(OH)D levels during the pandemic in winter/spring seasons in comparison to these levels in subjects in prepandemic winter/spring seasons (19.1±3.8 ng/mL vs. 17.2±3.7 ng/mL, P=0.006).Conclusion: During the COVID-19 pandemic, Korean children and adolescents showed similar serum 25(OH)D levels and vitamin D status to the prepandemic period, with a significant decrease in these measures observed in winter/spring seasons only. Prolonged confinement, such as in pandemic circumstances, underscores the need for vigilant monitoring of vitamin D status and supplementation, particularly in high-risk seasons.
Abstract
Purpose: Social distancing policies and school closures in South Korea induced by coronavirus disease 2019 have raised concerns about a lower chance of exposure to sunlight in children and adolescents. This study investigates changes in the vitamin D status of children and adolescents following the pandemic.Methods: This retrospective study includes healthy children aged 3–18 years who visited Hanyang University Hospitals in Seoul or Guri during pre-coronavirus disease 2019 (COVID-19) and post-COVID-19 pandemic periods. August 2017 to July 2019 is defined as the pre-COVID-19 pandemic period, while the period from July 2020 to July 2021 is defined as post-COVID-19 or "during the pandemic." Propensity scores were used to match the prepandemic and pandemic groups 1:1 based on age, sex, season of blood collection, and body mass index z-score to compare vitamin D status among subjects.Results: Among 786 eligible children, 506 were matched using propensity scores. There were no significant differences in mean serum 25-hydroxyvitamin D (25(OH) D) levels (20.1±6.5 ng/mL vs. 19.9±6.3 ng/mL, P>0.05) or vitamin D deficiency rates (53.0% vs. 54.9%, P>0.05) between the prepandemic and pandemic groups. Seasonal analysis revealed lower mean serum 25(OH)D levels during the pandemic in winter/spring seasons in comparison to these levels in subjects in prepandemic winter/spring seasons (19.1±3.8 ng/mL vs. 17.2±3.7 ng/mL, P=0.006).Conclusion: During the COVID-19 pandemic, Korean children and adolescents showed similar serum 25(OH)D levels and vitamin D status to the prepandemic period, with a significant decrease in these measures observed in winter/spring seasons only. Prolonged confinement, such as in pandemic circumstances, underscores the need for vigilant monitoring of vitamin D status and supplementation, particularly in high-risk seasons.
참고문헌 (26)
- Shin YH, "Vitamin D status and childhood health", Korean J Pediatr, 56, pp.417~423 (2013)
- Zurita-Cruz J, "Efficacy and safety of vitamin D supplementation in hospitalized COVID-19 pediatric patients : a randomized controlled trial", Front Pediatr, 10, pp.943529~ (2022)
- Ismailova A, "Vitamin D, infections and immunity", Rev Endocr Metab Disord, 23, pp.265~277 (2022)
- O’Neill CM, "Seasonal changes in vitamin D-effective UVB availability in Europe and associations with population serum 25-hydroxyvitamin D", Nutrients, 8, pp.533~ (2016)
- Holick MF, "The vitamin D deficiency pandemic : approaches for diagnosis, treatment and prevention", Rev Endocr Metab Disord, 18, pp.153~165 (2017)
- Dunton GF, "Early effects of the COVID-19pandemic on physical activity and sedentary behavior in children living in the U. S", BMC Public Health, 20, pp.1351~ (2020)
- "COVID-19, changes in infectious disease response over the past 3 years"[URL]
- Neville RD, "Global changes in child and adolescent physical activity during the COVID-19 pandemic : a systematic review and meta-analysis", JAMA Pediatr, 176, pp.886~894 (2022)
- Kang HM, "The impact of the coronavirus disease-2019 pandemic on childhood obesity and vitamin D status", J Korean Med Sci, 36, pp.e21~ (2021)
- Beyazgül G, "How vitamin D levels of children changed during COVID-19 pandemic : a comparison of prepandemic and pandemic periods", J Clin Res Pediatr Endocrinol, 14, pp.188~195 (2022)
- Holick MF, "Evaluation, treatment, and prevention of vitamin D deficiency : an Endocrine Society Clinical Practice Guideline", J Clin Endocrinol Metab, 96, pp.1911~1930 (2011)
- Mosca C, "Vitamin D levels in the pre-and post-COVID-19pandemic periods and related confinement at pediatric age", Nutrients, 15, pp.2089~ (2023)
- Fiamenghi VI, "Vitamin D deficiency in children and adolescents with obesity : a meta-analysis", J Pediatr(Rio J), 97, pp.273~279 (2021)
- Cheng S, "Adiposity, cardiometabolic risk, and vitamin D status : the Framingham Heart Study", Diabetes, 59, pp.242~248 (2010)
- Zakharova I, "Vitamin D insufficiency in overweight and obese children and adolescents", Front Endocrinol(Lausanne), 10, pp.103~ (2019)
- Wortsman J, "Decreased bioavailability of vitamin D in obesity", Am J Clin Nutr, 72, pp.690~693 (2000)
- Wierzbicka A, "Sex differences in vitamin D metabolism, serum levels and action", Br J Nutr, 128, pp.2115~2130 (2022)
- Muscogiuri G, "Sex differences of vitamin D status across BMI classes : an observational prospective cohort study", Nutrients, 11, pp.3034~ (2019)
- Boğa A, "Evaluation of the vitamin D levels of children according to seasons, gender and age", Haydarpasa Numune Med J, 61, pp.372~376 (2021)
- Kang S, "Changes in lifestyle and obesity during the COVID-19 pandemic in Korean adolescents : based on the Korea Youth Risk Behavior Survey 2019 and 2020", Ann Pediatr Endocrinol Metab, 27, pp.281~288 (2022)
- Knapp EA, "Changes in BMI during the COVID-19pandemic", Pediatrics, 150, pp.e2022056552~ (2022)
- Lee A, "Prevalence of vitamin D deficiency and insufficiency in Korean children and adolescents and associated factors", Lab Med Online, 6, pp.70~78 (2016)
- Won JW, "Seasonal changes in vitamin D levels of healthy children in mid-latitude, Asian urban area", Pediatr Gastroenterol Hepatol Nutr, 24, pp.207~217 (2021)
- Ha J, "COVID-19 waves and their characteristics in the Seoul metropolitan area(Jan 20, 2020-Aug 31, 2022)", Public Health Wkly Rep, 16, pp.111~136 (2023)
- "COVID-19 response white paper"[URL]
- Bener A, "Vitamin D deficiency in healthy children in a sunny country : associated factors", Int J Food Sci Nutr, 60(Suppl 5), pp.60~70 (2009)