Vitamin D deficiency in children aged 6 to 12 years: single center’s experience in Busan
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Purpose: This study investigated the prevalence and risk factors associated with vitamin D deficiency in children. Methods: We analyzed the medical records of 330 patients from the age of 6 to 12, who visited the endocrinology clinic of the Department of Pediatrics at Pusan National University Hospital, from September, 2013 to May, 2014. According to their serum 25-hydroxyvitamin D (25(OH)D) levels, the patients were grouped into either the deficiency group (25(OH)D<20 ng/mL), or the sufficiency group (25(OH)D≥20 ng/mL). The differences between the 2 groups were compared. Results: There were 195 patients (59.1%) who had vitamin D deficiency. Their mean serum 25(OH)D level was 14.86±3.20 ng/mL. The differences in sex, age, and pubertal status between the 2 groups were not statistically significant. Weight standard deviation score (SDS), and body mass index SDS, were significantly higher in the vitamin D deficiency group (P=0.002 for each), compared to the sufficiency group. Compared with Autumn, both Spring (odds ratio [OR], 9.7; 95% confidence interval [CI], 4.3–22.0), and Winter (OR, 5.9; 95% CI, 3.5–10.0), were risk factors for vitamin D deficiency. In multiple logistic regression analysis, only seasonal differences have been confirmed to have an effect on vitamin D deficiency. Conclusion: Vitamin D deficiency in children aged 6 to 12 years is very common. Spring and Winter are the most important risk factors for vitamin D deficiency. We suggest that it is necessary to
Abstract
Purpose: This study investigated the prevalence and risk factors associated with vitamin D deficiency in children. Methods: We analyzed the medical records of 330 patients from the age of 6 to 12, who visited the endocrinology clinic of the Department of Pediatrics at Pusan National University Hospital, from September, 2013 to May, 2014. According to their serum 25-hydroxyvitamin D (25(OH)D) levels, the patients were grouped into either the deficiency group (25(OH)D<20 ng/mL), or the sufficiency group (25(OH)D≥20 ng/mL). The differences between the 2 groups were compared. Results: There were 195 patients (59.1%) who had vitamin D deficiency. Their mean serum 25(OH)D level was 14.86±3.20 ng/mL. The differences in sex, age, and pubertal status between the 2 groups were not statistically significant. Weight standard deviation score (SDS), and body mass index SDS, were significantly higher in the vitamin D deficiency group (P=0.002 for each), compared to the sufficiency group. Compared with Autumn, both Spring (odds ratio [OR], 9.7; 95% confidence interval [CI], 4.3–22.0), and Winter (OR, 5.9; 95% CI, 3.5–10.0), were risk factors for vitamin D deficiency. In multiple logistic regression analysis, only seasonal differences have been confirmed to have an effect on vitamin D deficiency. Conclusion: Vitamin D deficiency in children aged 6 to 12 years is very common. Spring and Winter are the most important risk factors for vitamin D deficiency. We suggest that it is necessary to
참고문헌 (37)
- Wacker M, "Vitamin D - effects on skeletal and extraskeletal health and the need for supplementation", Nutrients, 5, pp.111~148 (2013)
- Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
- Pettifor J, "Vitamin D", pp.663~678 (1997), Academic Press
- Verstuyf A, "Vitamin D:a pleiotropic hormone", Kidney Int, 78, pp.140~145 (2010)
- Harel Z, "Low vitamin D status among obese adolescents: prevalence and response to treatment", J Adolesc Health, 48, pp.448~452 (2011)
- Temmerman JC, "Vitamin D and cardiovascular disease", J Am Coll Nutr, 30, pp.167~170 (2011)
- Searing DA, "Vitamin D in atopic dermatitis, asthma and allergic diseases", Immunol Allergy Clin North Am, 30, pp.397~409 (2010)
- Eder W, "The asthma epidemic", N Engl J Med, 355, pp.2226~2235 (2006)
- Chew A, "Does vitamin D affect timing of menarche?", Nutr Rev, 71, pp.189~193 (2013)
- Absoud M, "Prevalence and predictors of vitamin D insufficiency in children: a Great Britain population based study", PLoS One, 6, pp.e22179~ (2011)
- Tolppanen AM, "Risk factors for variation in 25-hydroxyvitamin D₃ and D₂concentrations and vitamin D deficiency in children", J Clin Endocrinol Metab, 97, pp.1202~1210 (2012)
- Munns CF, "Incidence of vitamin D deficiency rickets among Australian children: an Australian Paediatric Surveillance Unit study", Med J Aust, 196, pp.466~468 (2012)
- Ross AC, "The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know", J Clin Endocrinol Metab, 96, pp.53~58 (2011)
- Holick MF, "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline", J Clin Endocrinol Metab, 96, pp.1911~1930 (2011)
- Spiro A, "Vitamin D: an overview of vitamin D status and intake in Europe", Nutr Bull, 39, pp.322~350 (2014)
- Akhtar S, "Vitamin D status in South Asian populations:risks and opp or tunit ies", Crit Rev Food Sci Nutr, 56, pp.1925~1940 (2016)
- Carel JC, "Clinical practice: precocious puberty", N Engl J Med, 358, pp.2366~2377 (2008)
- Neely EK, "Spontaneous serum gonadotropin concentrations in the evaluation of precocious puberty", J Pediatr, 127, pp.47~52 (1995)
- 이동엽, "Relationship between serum 25-hydroxyvitamin D concentration and risks of metabolic syndrome in children and adolescents from Korean National Health and Nutrition Examination survey 2008–2010", Annals of Pediatirc Endocrinology & Metabolism, 20(1), pp.46~52 (2015), 대한소아내분비학회
- 황인혁, "Vitamin D deficiency in Korean children: prevalence, risk factors, and the relationship with parathyroid hormone levels", Annals of Pediatirc Endocrinology & Metabolism, 19(2), pp.86~90 (2014), 대한소아내분비학회
- Rovner AJ, "Hypovitaminosis D among healthy children in the United States: a review of the current evidence", Arch Pediatr Adolesc Med, 162, pp.513~519 (2008)
- Arnaud SB, "Serum 25-hydroxyvitamin D in infantile rickets", Pediatrics, 57, pp.221~225 (1976)
- Giovannucci E, "25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study", Arch Intern Med, 168, pp.1174~1180 (2008)
- Heaney RP, "Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D", J Am Coll Nutr, 22, pp.142~146 (2003)
- "Dietary reference intakes for Korean 2015" (2015)[URL]
- DeLuca HF, "Overview of general physiologic features and functions of vitamin D", Am J Clin Nutr, 80(6Suppl), pp.1689S~1696S (2004)
- Öhlund I, "Serum 25-hydroxyvitamin D levels in preschool-age children in northern Sweden are inadequate after summer and diminish further during winter", J Pediatr Gastroenterol Nutr, 56, pp.551~555 (2013)
- Gordon CM, "Prevalence of vitamin D deficiency among healthy adolescents", Arch Pediatr Adolesc Med, 158, pp.531~537 (2004)
- Guillemant J, "Vitamin D status during puberty in French healthy male adolescents", Osteoporos Int, 10, pp.222~225 (1999)
- Weng FL, "Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents", Am J Clin Nutr, 86, pp.150~158 (2007)
- Foo LH, "Relationship between vitamin D status, body composition and physical exercise of adolescent girls in Beijing", Osteoporos Int, 20, pp.417~425 (2009)
- Fraser DR, "Vitamin D-deficiency in Asia", J Steroid Biochem Mol Biol, 89(90), pp.491~495 (2004)
- Lee YA, "Adequate vitamin D status and adiposity contribute to bone health in peripubertal nonobese children", J Bone Miner Metab, 31, pp.337~345 (2013)
- Bell NH, "Evidence for alteration of the vitamin D-endocrine system in obese subjects", J Clin Invest, 76, pp.370~373 (1985)
- Wortsman J, "Decreased bioavailability of vitamin D in obesity", Am J Clin Nutr, 72, pp.690~693 (2000)
- Grivas TB, "Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes", Scoliosis, 1, pp.9~ (2006)
- Villamor E, "Vitamin D deficiency and age at menarche: a prospective study", Am J Clin Nutr, 94, pp.1020~1025 (2011)