침흘림에 대한 보툴리눔 톡신 치료
Botulinum Toxin Treatment for Sialorrhea
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초록
Sialorrhea is a distressing symptom for the patients with neurological conditions including cerebral palsy, parkinson's disease, amyotrophic lateral sclerosis and stroke, and it is mainly related to the disturbance in oral motor control rather than the excessive production of saliva in that patients. It can lead to some medical issues like oral hygiene, dentition and perioral dermatitis, and have a negative impact on social interaction. Also, the posterior drooling can cause coughing, choking and even serious respiratory complications such as aspiration pneumonia. A range of interventions, which are behavioral approach, pharmacologic approach, botulinum toxin (BoTN) injection, radiotherapy or surgery, exist that aim to reduce sialorrhea but there is a lack of consensus on management approach. Over the last decade, the injection of BoTN to salivary glands has emerged as a promising method to reduce sialorrhea and has been accepted as an effective and safe treatment in patients with neurological condition. Recently, several researchers tried to develop an international consensus statement, providing expert recommendations on assessment, intervention with BoTN, and aftercare for both pediatric and adult drooling. Sialorrea will be best managed by a multidisciplinary team, starting with a conservative approach and then leading to more invasive procedures as appropriate.
Abstract
Sialorrhea is a distressing symptom for the patients with neurological conditions including cerebral palsy, parkinson's disease, amyotrophic lateral sclerosis and stroke, and it is mainly related to the disturbance in oral motor control rather than the excessive production of saliva in that patients. It can lead to some medical issues like oral hygiene, dentition and perioral dermatitis, and have a negative impact on social interaction. Also, the posterior drooling can cause coughing, choking and even serious respiratory complications such as aspiration pneumonia. A range of interventions, which are behavioral approach, pharmacologic approach, botulinum toxin (BoTN) injection, radiotherapy or surgery, exist that aim to reduce sialorrhea but there is a lack of consensus on management approach. Over the last decade, the injection of BoTN to salivary glands has emerged as a promising method to reduce sialorrhea and has been accepted as an effective and safe treatment in patients with neurological condition. Recently, several researchers tried to develop an international consensus statement, providing expert recommendations on assessment, intervention with BoTN, and aftercare for both pediatric and adult drooling. Sialorrea will be best managed by a multidisciplinary team, starting with a conservative approach and then leading to more invasive procedures as appropriate.
참고문헌 (17)
- Blasco PA, "Drooling in the developmentally disabled: management practices and recommendations. Consortium on Drooling", Dev Med Child Neurol, 34, pp.849~862 (1992)
- Harriman M, "Use of radiotherapy for control of sialorrhea in patients with amyotrophic lateral sclerosis", J otolaryngol, 30, pp.242~245 (2001)
- Tahmassebi JF, "Prevalence of drooling in children with cerebral palsy attending special schools", Dev Med Child Neurol, 45, pp.613~617 (2003)
- Kalf JG, "Botulinum toxin A for drooling in Parkinson's disease:a pilot study to compare submandibular to parotid gland injections", Parkinsonism Relat disord, 13, pp.532~534 (2007)
- Blasco PA, "Surgical management of drooling", Dev Med Child Neurol, 34, pp.368~369 (1992)
- Jongerius PH, "The treatment of posterior drooling by botulinum toxin in a child with cerebral palsy", J Pediatr Gastroenterol Nutr, 41, pp.351~353 (2005)
- Reddihough D., "Botulinum toxin assessment, intervention and aftercare for paediatric and adult drooling: International consensus statement", Eur J Neurol, 17(S2), pp.109~121 (2010)
- Harris SR, "Drooling and its management in cerebral palsy", Dev Med Child Neurol, 29, pp.807~811 (1987)
- Lim M, "Botulinum toxin in the management of sialorrhea: a systemic review", Clinical Otolaryngol, 31, pp.267~272 (2006)
- Dand P, "The management of drooling in motor neuron disease", Int J Palliat Nurs, 16, pp.560~564 (2010)
- Dressler D, "Botulinum toxin : mechanisms of action", Eur Neurol, 53, pp.3~9 (2005)
- Bhatia KP, "Botulinum toxin is a useful treatment in excessive drooling in saliva", J Neurol Neurosurg Psychiatry, 67, pp.697~ (1999)
- Sriskandan N, "Ultrasound-guided submandibular gland injection of botulinum tosin for hypersalivation in cerebral palsy", Br J Oral Maxillofac Surg, 48, pp.58~60 (2010)
- Savarese R, "Intraparotid injection of botulinum toxin A as a treatment to control sialorrhea in children with cerebral palsy", Am J Phys Med Rehabil, 83(4), pp.304~311 (2004)
- Suskind DL, "Clinical study of botulinum-A toxin in the treatment of sialorrhea in children with cerebral palsy", Laryngoscope, 112(1), pp.73~81 (2002)
- Rodwell K, "Salivary gland botulinum toxin injections for drooling in children with cerebral palsy and neurodevelopmental disability: a systematic review", Dev Med Child Neurol, 54(11), pp.977~987 (2012)
- Guidubaldi A, "Botulinum toxin A versus B in sialorrhea:aprospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson's disease", Mov Disord, 26, pp.313~319 (2011)